Haematological Parameters and Enzyme Studies in Trypanosoma brucei-infected Rats Reared on Nigella sativa Oil-based Diet

The effect of Nigella sativa (black seed) oil based diet on the management of Trypanosoma brucei infected rats was investigated. Prasitaemia was monitored and haematological and enzymatic studies were carried out on liver and blood of infected rats fed with diet formulated with black seed oil (treat...

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Veröffentlicht in:Asian journal of biochemistry 2011-01, Vol.6 (1), p.90-97
Hauptverfasser: Faremi, A.Y., Ekanem, J.T.
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description The effect of Nigella sativa (black seed) oil based diet on the management of Trypanosoma brucei infected rats was investigated. Prasitaemia was monitored and haematological and enzymatic studies were carried out on liver and blood of infected rats fed with diet formulated with black seed oil (treatment). Comparison was made with untreated infected rats and uninfected rats. The diet formulated with black seed oil extended the life span for 7 and 5 days for prophylactic and early stage feeding, respectively while the late stage feeding extended it by a day. The T. brucei-infection significantly (p
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Prasitaemia was monitored and haematological and enzymatic studies were carried out on liver and blood of infected rats fed with diet formulated with black seed oil (treatment). Comparison was made with untreated infected rats and uninfected rats. The diet formulated with black seed oil extended the life span for 7 and 5 days for prophylactic and early stage feeding, respectively while the late stage feeding extended it by a day. The T. brucei-infection significantly (p&lt;0.05) increased liver Glutamate Oxaloacetate Transaminase (GOT), Qutamate Pyruvate Transaminase (GPT) and Gamma Glutamyl Transaminase (GGT). Serum GOT and GPT specific activities were also significantly (p&lt;0.05) increased. However serum GGT activity showed no significant (p&lt;0.05) difference in all the rat groups. While haemoglobin concentration, white blood cells, red blood cells, pack cell volume, mean cell haemoglobin concentration and platelet were significantly (p&lt;0.05) reduced, as observed in the control and late stage feeding, by the infection, prophylactic and early stage feeding with diet formulated with N. sativa oil significantly (p&lt;0.05) improved the parameters towards those obtained in uninfected rats. 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Prasitaemia was monitored and haematological and enzymatic studies were carried out on liver and blood of infected rats fed with diet formulated with black seed oil (treatment). Comparison was made with untreated infected rats and uninfected rats. The diet formulated with black seed oil extended the life span for 7 and 5 days for prophylactic and early stage feeding, respectively while the late stage feeding extended it by a day. The T. brucei-infection significantly (p&lt;0.05) increased liver Glutamate Oxaloacetate Transaminase (GOT), Qutamate Pyruvate Transaminase (GPT) and Gamma Glutamyl Transaminase (GGT). Serum GOT and GPT specific activities were also significantly (p&lt;0.05) increased. However serum GGT activity showed no significant (p&lt;0.05) difference in all the rat groups. While haemoglobin concentration, white blood cells, red blood cells, pack cell volume, mean cell haemoglobin concentration and platelet were significantly (p&lt;0.05) reduced, as observed in the control and late stage feeding, by the infection, prophylactic and early stage feeding with diet formulated with N. sativa oil significantly (p&lt;0.05) improved the parameters towards those obtained in uninfected rats. 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Prasitaemia was monitored and haematological and enzymatic studies were carried out on liver and blood of infected rats fed with diet formulated with black seed oil (treatment). Comparison was made with untreated infected rats and uninfected rats. The diet formulated with black seed oil extended the life span for 7 and 5 days for prophylactic and early stage feeding, respectively while the late stage feeding extended it by a day. The T. brucei-infection significantly (p&lt;0.05) increased liver Glutamate Oxaloacetate Transaminase (GOT), Qutamate Pyruvate Transaminase (GPT) and Gamma Glutamyl Transaminase (GGT). Serum GOT and GPT specific activities were also significantly (p&lt;0.05) increased. However serum GGT activity showed no significant (p&lt;0.05) difference in all the rat groups. 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title Haematological Parameters and Enzyme Studies in Trypanosoma brucei-infected Rats Reared on Nigella sativa Oil-based Diet
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