Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: A pilot study
Mirtazapine (MRT) is a human antidepressant drug mainly metabolised by the cytochrome P450 enzyme system to 8-OH mirtazapine (8-OH) and dimetilmirtazapine (DMR). The drug is usually administered to dogs with anorexia according to doses extrapolated from humans, although it could also have applicatio...
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| Veröffentlicht in: | The veterinary journal (1997) 2012-05, Vol.192 (2), p.239-241 |
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| creator | Giorgi, Mario Yun, Hyoin |
| description | Mirtazapine (MRT) is a human antidepressant drug mainly metabolised by the cytochrome P450 enzyme system to 8-OH mirtazapine (8-OH) and dimetilmirtazapine (DMR). The drug is usually administered to dogs with anorexia according to doses extrapolated from humans, although it could also have applications as an antidepressant and analgesic in this species. The aim of this study was to assess the pharmacokinetics of MRT and its metabolites, DMT and 8-OH. Six healthy male Beagle dogs were administered MRT orally (20mg/dog) and plasma MRT and metabolite concentrations were evaluated by high performance liquid chromatography with fluorescence detection.
The pharmacokinetic profiles of MRT and DMR were similar (detected from 0.25 up to 10h), while 8-OH (detected from 0.50 up to 10h) attained the highest concentrations. The mean half-life of MRT was 6.17h with a clearance of 1193mL/h/kg. The study showed that MRT has a different pharmacokinetic profile in the dog compared to other species. |
| doi_str_mv | 10.1016/j.tvjl.2011.05.010 |
| format | Article |
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The pharmacokinetic profiles of MRT and DMR were similar (detected from 0.25 up to 10h), while 8-OH (detected from 0.50 up to 10h) attained the highest concentrations. The mean half-life of MRT was 6.17h with a clearance of 1193mL/h/kg. The study showed that MRT has a different pharmacokinetic profile in the dog compared to other species.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2011.05.010</identifier><identifier>PMID: 21652240</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Administration, Oral ; analgesics ; Animals ; anorexia ; antidepressants ; Antidepressive Agents, Tricyclic - administration & dosage ; Antidepressive Agents, Tricyclic - blood ; Antidepressive Agents, Tricyclic - pharmacokinetics ; Beagle ; Beagle dogs ; Chromatography, High Pressure Liquid - methods ; Chromatography, High Pressure Liquid - veterinary ; cytochrome P-450 ; dogs ; Dogs - metabolism ; fluorescence ; Half-Life ; high performance liquid chromatography ; Male ; Metabolic Clearance Rate ; Metabolites ; Mianserin - administration & dosage ; Mianserin - analogs & derivatives ; Mianserin - blood ; Mianserin - pharmacokinetics ; Mirtazapine ; Oral administration ; Pharmacokinetics ; Pilot Projects</subject><ispartof>The veterinary journal (1997), 2012-05, Vol.192 (2), p.239-241</ispartof><rights>2011 Elsevier Ltd</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-9be73182a69ce3c0beea4d8447660825590be0289bfe4b80490e79059df8c27b3</citedby><cites>FETCH-LOGICAL-c380t-9be73182a69ce3c0beea4d8447660825590be0289bfe4b80490e79059df8c27b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tvjl.2011.05.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21652240$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giorgi, Mario</creatorcontrib><creatorcontrib>Yun, Hyoin</creatorcontrib><title>Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: A pilot study</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>Mirtazapine (MRT) is a human antidepressant drug mainly metabolised by the cytochrome P450 enzyme system to 8-OH mirtazapine (8-OH) and dimetilmirtazapine (DMR). The drug is usually administered to dogs with anorexia according to doses extrapolated from humans, although it could also have applications as an antidepressant and analgesic in this species. The aim of this study was to assess the pharmacokinetics of MRT and its metabolites, DMT and 8-OH. Six healthy male Beagle dogs were administered MRT orally (20mg/dog) and plasma MRT and metabolite concentrations were evaluated by high performance liquid chromatography with fluorescence detection.
The pharmacokinetic profiles of MRT and DMR were similar (detected from 0.25 up to 10h), while 8-OH (detected from 0.50 up to 10h) attained the highest concentrations. The mean half-life of MRT was 6.17h with a clearance of 1193mL/h/kg. The study showed that MRT has a different pharmacokinetic profile in the dog compared to other species.</description><subject>Administration, Oral</subject><subject>analgesics</subject><subject>Animals</subject><subject>anorexia</subject><subject>antidepressants</subject><subject>Antidepressive Agents, Tricyclic - administration & dosage</subject><subject>Antidepressive Agents, Tricyclic - blood</subject><subject>Antidepressive Agents, Tricyclic - pharmacokinetics</subject><subject>Beagle</subject><subject>Beagle dogs</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Chromatography, High Pressure Liquid - veterinary</subject><subject>cytochrome P-450</subject><subject>dogs</subject><subject>Dogs - metabolism</subject><subject>fluorescence</subject><subject>Half-Life</subject><subject>high performance liquid chromatography</subject><subject>Male</subject><subject>Metabolic Clearance Rate</subject><subject>Metabolites</subject><subject>Mianserin - administration & dosage</subject><subject>Mianserin - analogs & derivatives</subject><subject>Mianserin - blood</subject><subject>Mianserin - pharmacokinetics</subject><subject>Mirtazapine</subject><subject>Oral administration</subject><subject>Pharmacokinetics</subject><subject>Pilot Projects</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFO3DAQhi1UxMLSF-BQfOwlYezESVz1QlelRUICCejVcpzJ4m0SL7YXafv0eLXQI4eRx6Nvfo0-Qs4Y5AxYdbHK48tqyDkwloPIgcEBOWai4BmXNfuUepCQAS-KGTkJYQUAsiz5EZlxVgnOSzgmf-6etB-1cX_thNGaQF1PR-uj_qfXaUT11FEbAx21neiIUbdusBEDTd8fqJcD0s4twzd6Sdd2cJGGuOm2p-Sw10PAz2_vnDxe_XxY_M5ubn9dLy5vMlM0EDPZYl2whutKGiwMtIi67JqyrKsKGi6ETCPgjWx7LNsGSglYSxCy6xvD67aYk6_73LV3zxsMUY02GBwGPaHbBJU8MSabupYJ5XvUeBeCx16tvR213yZox1VqpXY-1c6nAqGSz7T05S1_047Y_V95F5iA8z3Qa6f00tugHu9TgoBUvKhFIr7vCUweXix6FYzFyWBnPZqoOmc_uuAVjhePVQ</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Giorgi, Mario</creator><creator>Yun, Hyoin</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: A pilot study</title><author>Giorgi, Mario ; Yun, Hyoin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-9be73182a69ce3c0beea4d8447660825590be0289bfe4b80490e79059df8c27b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Oral</topic><topic>analgesics</topic><topic>Animals</topic><topic>anorexia</topic><topic>antidepressants</topic><topic>Antidepressive Agents, Tricyclic - administration & dosage</topic><topic>Antidepressive Agents, Tricyclic - blood</topic><topic>Antidepressive Agents, Tricyclic - pharmacokinetics</topic><topic>Beagle</topic><topic>Beagle dogs</topic><topic>Chromatography, High Pressure Liquid - methods</topic><topic>Chromatography, High Pressure Liquid - veterinary</topic><topic>cytochrome P-450</topic><topic>dogs</topic><topic>Dogs - metabolism</topic><topic>fluorescence</topic><topic>Half-Life</topic><topic>high performance liquid chromatography</topic><topic>Male</topic><topic>Metabolic Clearance Rate</topic><topic>Metabolites</topic><topic>Mianserin - administration & dosage</topic><topic>Mianserin - analogs & derivatives</topic><topic>Mianserin - blood</topic><topic>Mianserin - pharmacokinetics</topic><topic>Mirtazapine</topic><topic>Oral administration</topic><topic>Pharmacokinetics</topic><topic>Pilot Projects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giorgi, Mario</creatorcontrib><creatorcontrib>Yun, Hyoin</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giorgi, Mario</au><au>Yun, Hyoin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: A pilot study</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>192</volume><issue>2</issue><spage>239</spage><epage>241</epage><pages>239-241</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>Mirtazapine (MRT) is a human antidepressant drug mainly metabolised by the cytochrome P450 enzyme system to 8-OH mirtazapine (8-OH) and dimetilmirtazapine (DMR). The drug is usually administered to dogs with anorexia according to doses extrapolated from humans, although it could also have applications as an antidepressant and analgesic in this species. The aim of this study was to assess the pharmacokinetics of MRT and its metabolites, DMT and 8-OH. Six healthy male Beagle dogs were administered MRT orally (20mg/dog) and plasma MRT and metabolite concentrations were evaluated by high performance liquid chromatography with fluorescence detection.
The pharmacokinetic profiles of MRT and DMR were similar (detected from 0.25 up to 10h), while 8-OH (detected from 0.50 up to 10h) attained the highest concentrations. The mean half-life of MRT was 6.17h with a clearance of 1193mL/h/kg. The study showed that MRT has a different pharmacokinetic profile in the dog compared to other species.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>21652240</pmid><doi>10.1016/j.tvjl.2011.05.010</doi><tpages>3</tpages></addata></record> |
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| ispartof | The veterinary journal (1997), 2012-05, Vol.192 (2), p.239-241 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Administration, Oral analgesics Animals anorexia antidepressants Antidepressive Agents, Tricyclic - administration & dosage Antidepressive Agents, Tricyclic - blood Antidepressive Agents, Tricyclic - pharmacokinetics Beagle Beagle dogs Chromatography, High Pressure Liquid - methods Chromatography, High Pressure Liquid - veterinary cytochrome P-450 dogs Dogs - metabolism fluorescence Half-Life high performance liquid chromatography Male Metabolic Clearance Rate Metabolites Mianserin - administration & dosage Mianserin - analogs & derivatives Mianserin - blood Mianserin - pharmacokinetics Mirtazapine Oral administration Pharmacokinetics Pilot Projects |
| title | Pharmacokinetics of mirtazapine and its main metabolites in Beagle dogs: A pilot study |
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