Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy
Background: Maternal hypothyroidism [overt hypothyroidism and subclinical hypothyroidism (SCH)] during early pregnancy is suspected to associate with adverse obstetrical outcomes. Aim: The aim of the present study was to investigate whether maternal SCH during the early stage of pregnancy increase o...
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| Veröffentlicht in: | Journal of endocrinological investigation 2012-03, Vol.35 (3), p.322-325 |
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| creator | Wang, S. Teng, W. P. Li, J. X. Wang, W. W. Shan, Z. Y. |
| description | Background:
Maternal hypothyroidism [overt hypothyroidism and subclinical hypothyroidism (SCH)] during early pregnancy is suspected to associate with adverse obstetrical outcomes.
Aim:
The aim of the present study was to investigate whether maternal SCH during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes.
Subjects and methods:
A total of 756 women in the 1
st
trimester (≤12 weeks) of pregnancy were enrolled through 10 hospitals in Shenyang from 2007 to 2009. All participants underwent thyroid function testing in early pregnancy and their obstetrical outcomes were studied following delivery.
Results:
The incidence of spontaneous abortions in the SCH group was higher than the normal TSH group (15.48%
vs
8.86%,
p
=0.03). No significant association was observed between SCH and other obstetrical complications including gestational hypertension, premature delivery, anemia,
post-partum
hemorrhage, low neonatal Apgar scores and low birth weight. Although levo-T
4
(L-T
4
) treatment decreased the incidence of spontaneous abortions in women with SCH, it was not statistically significant when compared to women who did not receive treatment in the SCH group. None of the 28 women who received L-T
4
treatment had premature delivery, low birth weight, hemorrhage, and low Apgar score.
Conclusions:
The incidence of spontaneous abortion in pregnant women with SCH increases in early pregnancy. |
| doi_str_mv | 10.3275/7772 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1011195986</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1011195986</sourcerecordid><originalsourceid>FETCH-LOGICAL-c276t-4a7c335281e9c75f602c8ed6bd4a75f653573b5010780f1467cd9d29419f524e3</originalsourceid><addsrcrecordid>eNo1kMtOwzAQRS0EoqXlF5A3SGwCfsR2vERVeUiV2MASRY4zaVMlcbCdRf6ehJbVzOgejWYOQmtKHjlT4kkpxS7QkipGkoxn8hItCdc0SYlWC3QTwpEQrnimrtGCUZkyJeUSfW-rCmwM2FW4NRF8ZxochsI2dVfbqT-MvYuH0bu6rEOLXYddESJE_5e6IVrXQsDl4Otuj8H4ZsS9h31nOjuu0VVlmgC357pCXy_bz81bsvt4fd887xI7XRGT1CjLuWAZBW2VqCRhNoNSFuWUTKPgQvFCEEpURiqaSmVLXTKdUl0JlgJfoYfT3t67nwFCzNs6WGga04EbQk4JpVQLnckJvTujQ9FCmfe-bo0f838lE3B_AkI_vwQ-P7ph1jKvyWfV-aya_wJoIW3b</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1011195986</pqid></control><display><type>article</type><title>Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy</title><source>MEDLINE</source><source>SpringerLink</source><creator>Wang, S. ; Teng, W. P. ; Li, J. X. ; Wang, W. W. ; Shan, Z. Y.</creator><creatorcontrib>Wang, S. ; Teng, W. P. ; Li, J. X. ; Wang, W. W. ; Shan, Z. Y.</creatorcontrib><description>Background:
Maternal hypothyroidism [overt hypothyroidism and subclinical hypothyroidism (SCH)] during early pregnancy is suspected to associate with adverse obstetrical outcomes.
Aim:
The aim of the present study was to investigate whether maternal SCH during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes.
Subjects and methods:
A total of 756 women in the 1
st
trimester (≤12 weeks) of pregnancy were enrolled through 10 hospitals in Shenyang from 2007 to 2009. All participants underwent thyroid function testing in early pregnancy and their obstetrical outcomes were studied following delivery.
Results:
The incidence of spontaneous abortions in the SCH group was higher than the normal TSH group (15.48%
vs
8.86%,
p
=0.03). No significant association was observed between SCH and other obstetrical complications including gestational hypertension, premature delivery, anemia,
post-partum
hemorrhage, low neonatal Apgar scores and low birth weight. Although levo-T
4
(L-T
4
) treatment decreased the incidence of spontaneous abortions in women with SCH, it was not statistically significant when compared to women who did not receive treatment in the SCH group. None of the 28 women who received L-T
4
treatment had premature delivery, low birth weight, hemorrhage, and low Apgar score.
Conclusions:
The incidence of spontaneous abortion in pregnant women with SCH increases in early pregnancy.</description><identifier>ISSN: 0391-4097</identifier><identifier>EISSN: 1720-8386</identifier><identifier>DOI: 10.3275/7772</identifier><identifier>PMID: 21642766</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abortion, Spontaneous - epidemiology ; Abortion, Spontaneous - metabolism ; Adult ; Anemia - epidemiology ; Anemia - metabolism ; Endocrinology ; Female ; Humans ; Hypertension, Pregnancy-Induced - epidemiology ; Hypertension, Pregnancy-Induced - metabolism ; Hypothyroidism - epidemiology ; Hypothyroidism - metabolism ; Incidence ; Longitudinal Studies ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Original Articles ; Postpartum Hemorrhage - epidemiology ; Postpartum Hemorrhage - metabolism ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy Complications - metabolism ; Pregnancy Outcome - epidemiology ; Pregnancy Trimester, First - metabolism ; Premature Birth - epidemiology ; Premature Birth - metabolism ; Risk Factors ; Young Adult</subject><ispartof>Journal of endocrinological investigation, 2012-03, Vol.35 (3), p.322-325</ispartof><rights>Italian Society of Endocrinology (SIE) 2012</rights><rights>2012, Editrice Kurtis.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c276t-4a7c335281e9c75f602c8ed6bd4a75f653573b5010780f1467cd9d29419f524e3</citedby><cites>FETCH-LOGICAL-c276t-4a7c335281e9c75f602c8ed6bd4a75f653573b5010780f1467cd9d29419f524e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.3275/7772$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.3275/7772$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21642766$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, S.</creatorcontrib><creatorcontrib>Teng, W. P.</creatorcontrib><creatorcontrib>Li, J. X.</creatorcontrib><creatorcontrib>Wang, W. W.</creatorcontrib><creatorcontrib>Shan, Z. Y.</creatorcontrib><title>Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy</title><title>Journal of endocrinological investigation</title><addtitle>J Endocrinol Invest</addtitle><addtitle>J Endocrinol Invest</addtitle><description>Background:
Maternal hypothyroidism [overt hypothyroidism and subclinical hypothyroidism (SCH)] during early pregnancy is suspected to associate with adverse obstetrical outcomes.
Aim:
The aim of the present study was to investigate whether maternal SCH during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes.
Subjects and methods:
A total of 756 women in the 1
st
trimester (≤12 weeks) of pregnancy were enrolled through 10 hospitals in Shenyang from 2007 to 2009. All participants underwent thyroid function testing in early pregnancy and their obstetrical outcomes were studied following delivery.
Results:
The incidence of spontaneous abortions in the SCH group was higher than the normal TSH group (15.48%
vs
8.86%,
p
=0.03). No significant association was observed between SCH and other obstetrical complications including gestational hypertension, premature delivery, anemia,
post-partum
hemorrhage, low neonatal Apgar scores and low birth weight. Although levo-T
4
(L-T
4
) treatment decreased the incidence of spontaneous abortions in women with SCH, it was not statistically significant when compared to women who did not receive treatment in the SCH group. None of the 28 women who received L-T
4
treatment had premature delivery, low birth weight, hemorrhage, and low Apgar score.
Conclusions:
The incidence of spontaneous abortion in pregnant women with SCH increases in early pregnancy.</description><subject>Abortion, Spontaneous - epidemiology</subject><subject>Abortion, Spontaneous - metabolism</subject><subject>Adult</subject><subject>Anemia - epidemiology</subject><subject>Anemia - metabolism</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Humans</subject><subject>Hypertension, Pregnancy-Induced - epidemiology</subject><subject>Hypertension, Pregnancy-Induced - metabolism</subject><subject>Hypothyroidism - epidemiology</subject><subject>Hypothyroidism - metabolism</subject><subject>Incidence</subject><subject>Longitudinal Studies</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Middle Aged</subject><subject>Original Articles</subject><subject>Postpartum Hemorrhage - epidemiology</subject><subject>Postpartum Hemorrhage - metabolism</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Complications - metabolism</subject><subject>Pregnancy Outcome - epidemiology</subject><subject>Pregnancy Trimester, First - metabolism</subject><subject>Premature Birth - epidemiology</subject><subject>Premature Birth - metabolism</subject><subject>Risk Factors</subject><subject>Young Adult</subject><issn>0391-4097</issn><issn>1720-8386</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRS0EoqXlF5A3SGwCfsR2vERVeUiV2MASRY4zaVMlcbCdRf6ehJbVzOgejWYOQmtKHjlT4kkpxS7QkipGkoxn8hItCdc0SYlWC3QTwpEQrnimrtGCUZkyJeUSfW-rCmwM2FW4NRF8ZxochsI2dVfbqT-MvYuH0bu6rEOLXYddESJE_5e6IVrXQsDl4Otuj8H4ZsS9h31nOjuu0VVlmgC357pCXy_bz81bsvt4fd887xI7XRGT1CjLuWAZBW2VqCRhNoNSFuWUTKPgQvFCEEpURiqaSmVLXTKdUl0JlgJfoYfT3t67nwFCzNs6WGga04EbQk4JpVQLnckJvTujQ9FCmfe-bo0f838lE3B_AkI_vwQ-P7ph1jKvyWfV-aya_wJoIW3b</recordid><startdate>20120301</startdate><enddate>20120301</enddate><creator>Wang, S.</creator><creator>Teng, W. P.</creator><creator>Li, J. X.</creator><creator>Wang, W. W.</creator><creator>Shan, Z. Y.</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20120301</creationdate><title>Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy</title><author>Wang, S. ; Teng, W. P. ; Li, J. X. ; Wang, W. W. ; Shan, Z. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c276t-4a7c335281e9c75f602c8ed6bd4a75f653573b5010780f1467cd9d29419f524e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Abortion, Spontaneous - epidemiology</topic><topic>Abortion, Spontaneous - metabolism</topic><topic>Adult</topic><topic>Anemia - epidemiology</topic><topic>Anemia - metabolism</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Humans</topic><topic>Hypertension, Pregnancy-Induced - epidemiology</topic><topic>Hypertension, Pregnancy-Induced - metabolism</topic><topic>Hypothyroidism - epidemiology</topic><topic>Hypothyroidism - metabolism</topic><topic>Incidence</topic><topic>Longitudinal Studies</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Middle Aged</topic><topic>Original Articles</topic><topic>Postpartum Hemorrhage - epidemiology</topic><topic>Postpartum Hemorrhage - metabolism</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Complications - metabolism</topic><topic>Pregnancy Outcome - epidemiology</topic><topic>Pregnancy Trimester, First - metabolism</topic><topic>Premature Birth - epidemiology</topic><topic>Premature Birth - metabolism</topic><topic>Risk Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, S.</creatorcontrib><creatorcontrib>Teng, W. P.</creatorcontrib><creatorcontrib>Li, J. X.</creatorcontrib><creatorcontrib>Wang, W. W.</creatorcontrib><creatorcontrib>Shan, Z. Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of endocrinological investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, S.</au><au>Teng, W. P.</au><au>Li, J. X.</au><au>Wang, W. W.</au><au>Shan, Z. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy</atitle><jtitle>Journal of endocrinological investigation</jtitle><stitle>J Endocrinol Invest</stitle><addtitle>J Endocrinol Invest</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>35</volume><issue>3</issue><spage>322</spage><epage>325</epage><pages>322-325</pages><issn>0391-4097</issn><eissn>1720-8386</eissn><abstract>Background:
Maternal hypothyroidism [overt hypothyroidism and subclinical hypothyroidism (SCH)] during early pregnancy is suspected to associate with adverse obstetrical outcomes.
Aim:
The aim of the present study was to investigate whether maternal SCH during the early stage of pregnancy increase obstetrical complications and whether treatment results in an improvement in these outcomes.
Subjects and methods:
A total of 756 women in the 1
st
trimester (≤12 weeks) of pregnancy were enrolled through 10 hospitals in Shenyang from 2007 to 2009. All participants underwent thyroid function testing in early pregnancy and their obstetrical outcomes were studied following delivery.
Results:
The incidence of spontaneous abortions in the SCH group was higher than the normal TSH group (15.48%
vs
8.86%,
p
=0.03). No significant association was observed between SCH and other obstetrical complications including gestational hypertension, premature delivery, anemia,
post-partum
hemorrhage, low neonatal Apgar scores and low birth weight. Although levo-T
4
(L-T
4
) treatment decreased the incidence of spontaneous abortions in women with SCH, it was not statistically significant when compared to women who did not receive treatment in the SCH group. None of the 28 women who received L-T
4
treatment had premature delivery, low birth weight, hemorrhage, and low Apgar score.
Conclusions:
The incidence of spontaneous abortion in pregnant women with SCH increases in early pregnancy.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>21642766</pmid><doi>10.3275/7772</doi><tpages>4</tpages></addata></record> |
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| subjects | Abortion, Spontaneous - epidemiology Abortion, Spontaneous - metabolism Adult Anemia - epidemiology Anemia - metabolism Endocrinology Female Humans Hypertension, Pregnancy-Induced - epidemiology Hypertension, Pregnancy-Induced - metabolism Hypothyroidism - epidemiology Hypothyroidism - metabolism Incidence Longitudinal Studies Medicine Medicine & Public Health Metabolic Diseases Middle Aged Original Articles Postpartum Hemorrhage - epidemiology Postpartum Hemorrhage - metabolism Pregnancy Pregnancy Complications - epidemiology Pregnancy Complications - metabolism Pregnancy Outcome - epidemiology Pregnancy Trimester, First - metabolism Premature Birth - epidemiology Premature Birth - metabolism Risk Factors Young Adult |
| title | Effects of maternal subclinical hypothyroidism on obstetrical outcomes during early pregnancy |
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