Phenyliodine Bis(trifluoroacetate)-Mediated Oxidative C–C Bond Formation: Synthesis of 3-Hydroxy-2-oxindoles and Spirooxindoles from Anilides

The reaction of phenyliodine bis(trifluoroacetate) (PIFA) with a series of anilides 1 (E = CO2Et) in CF3CH2OH was found to give 3-hydroxy-2-oxindole derivatives 2, while that with various anilides 1′ (E = CON(R4)Ar) afforded the C 2-symmetric or unsymmetric spirooxindoles 3. These processes feature...

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Veröffentlicht in:	Organic letters 2012-05, Vol.14 (9), p.2210-2213
Hauptverfasser:	Wang, Junwei, Yuan, Yucheng, Xiong, Rui, Zhang-Negrerie, Daisy, Du, Yunfei, Zhao, Kang
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - chemistry Combinatorial Chemistry Techniques Fluoroacetates Indoles - chemical synthesis Indoles - chemistry Molecular Structure Oxidation-Reduction Trifluoroacetic Acid - chemistry
Online-Zugang:	Volltext
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