Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model

Dysferlin mutations cause muscular dystrophy (dysferlinopathy) characterized by adult onset muscle weakness, high serum creatine kinase levels, attenuation of muscle regeneration and a prominent inflammatory infiltrate. In order to verify the role of lymphocytes and immune cells on this disease, we...

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Veröffentlicht in:	Experimental cell research 2012-06, Vol.318 (10), p.1160-1174
Hauptverfasser:	Farini, Andrea, Sitzia, Clementina, Navarro, Claire, D'Antona, Giuseppe, Belicchi, Marzia, Parolini, Daniele, Del Fraro, Giulia, Razini, Paola, Bottinelli, Roberto, Meregalli, Mirella, Torrente, Yvan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - pathology Complement Membrane Attack Complex - metabolism Disease Models, Animal Dysferlin Dystrophin - metabolism Endothelial Cells - pathology Female Hybridization, Genetic Immune system In Vitro Techniques Inflammation Laminin - metabolism Lymphocytes Macrophages - pathology Male Membrane Proteins - deficiency Membrane Proteins - genetics Membrane Proteins - metabolism Mice Mice, Inbred C57BL Mice, Knockout Mice, SCID Muscle Contraction Muscle, Skeletal - blood supply Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscle, Skeletal - physiopathology Muscular dystrophy Muscular Dystrophy, Animal - metabolism Muscular Dystrophy, Animal - pathology Muscular system Regeneration Rodents Sarcoglycans - metabolism Sarcolemma - genetics Sarcolemma - metabolism Sarcolemma - pathology Scid/A/J mice T-Lymphocytes - pathology
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