Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus
To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nes...
Gespeichert in:
| Veröffentlicht in: | Endocrine 2012-06, Vol.41 (3), p.424-429 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 429 |
|---|---|
| container_issue | 3 |
| container_start_page | 424 |
| container_title | Endocrine |
| container_volume | 41 |
| creator | Aslan, Mehmet Celik, Onder Celik, Nilufer Turkcuoglu, Ilgin Yilmaz, Ercan Karaer, Abdullah Simsek, Yavuz Celik, Ebru Aydin, Suleyman |
| description | To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 ± 8.3 vs. 9.6 ± 5.9 ng/ml,
P
= 0.001) and nesfatin-1 levels were found lower (5.5 ± 8.1 vs. 8.1 ± 23.9 ng/ml,
P
= 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 ± 4.3 and 8.2 ± 1.9 ng/ml,
P
= 0.618) and nesfatin-1 levels (5.4 ± 4.0 and 6.2 ± 10.3 ng/ml,
P
= 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM. |
| doi_str_mv | 10.1007/s12020-011-9577-8 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1011190063</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1011190063</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-559993f98ffa1405442aa650b507b0173048c58c75c20b9b03feea946d39cbca3</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EoqXwACzII4vh-JbEI6q4iUosILFZtuNUqdy4xAkSb4-rFEam48t3fv36ELqkcEMByttEGTAgQClRsixJdYTmVEqVXwCO85lLSQCqjxk6S2kDwBgrylM0yxO4KKo5elnGvsY2xFjjzqfGDG1HKDZdjc3Oh3zhBQ7-y4eE2w6vfRoyEjsTcN0a6wef8NaH0A5jOkcnjQnJXxzmAr0_3L8tn8jq9fF5ebcijgsxkFxQKd6oqmkMFSCFYMYUEqyE0gItOYjKycqV0jGwygJvvDdKFDVXzjrDF-h6yt318XPMjfS2TS6XMJ2PY9I0C6EKoOAZpRPq-phS7xu969ut6b8zpPcO9eRQ5xW9d6irvHN1iB_t1td_G7_SMsAmIOWvbu17vYljn5Wkf1J_AFi_es4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1011190063</pqid></control><display><type>article</type><title>Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Aslan, Mehmet ; Celik, Onder ; Celik, Nilufer ; Turkcuoglu, Ilgin ; Yilmaz, Ercan ; Karaer, Abdullah ; Simsek, Yavuz ; Celik, Ebru ; Aydin, Suleyman</creator><creatorcontrib>Aslan, Mehmet ; Celik, Onder ; Celik, Nilufer ; Turkcuoglu, Ilgin ; Yilmaz, Ercan ; Karaer, Abdullah ; Simsek, Yavuz ; Celik, Ebru ; Aydin, Suleyman</creatorcontrib><description>To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 ± 8.3 vs. 9.6 ± 5.9 ng/ml,
P
= 0.001) and nesfatin-1 levels were found lower (5.5 ± 8.1 vs. 8.1 ± 23.9 ng/ml,
P
= 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 ± 4.3 and 8.2 ± 1.9 ng/ml,
P
= 0.618) and nesfatin-1 levels (5.4 ± 4.0 and 6.2 ± 10.3 ng/ml,
P
= 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.</description><identifier>ISSN: 1355-008X</identifier><identifier>EISSN: 1559-0100</identifier><identifier>DOI: 10.1007/s12020-011-9577-8</identifier><identifier>PMID: 22203468</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Apelin ; Biomarkers - blood ; Birth Weight ; Calcium-Binding Proteins - blood ; Diabetes ; Diabetes, Gestational - blood ; DNA-Binding Proteins - blood ; Endocrinology ; Female ; Fetal Blood - metabolism ; Gestational Age ; Humanities and Social Sciences ; Humans ; Infant, Newborn ; Insulin - blood ; Intercellular Signaling Peptides and Proteins - blood ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; multidisciplinary ; Nerve Tissue Proteins - blood ; Original Article ; Pilot Projects ; Postpartum Period - blood ; Pregnancy ; Science</subject><ispartof>Endocrine, 2012-06, Vol.41 (3), p.424-429</ispartof><rights>Springer Science+Business Media, LLC 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-559993f98ffa1405442aa650b507b0173048c58c75c20b9b03feea946d39cbca3</citedby><cites>FETCH-LOGICAL-c344t-559993f98ffa1405442aa650b507b0173048c58c75c20b9b03feea946d39cbca3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12020-011-9577-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12020-011-9577-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22203468$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aslan, Mehmet</creatorcontrib><creatorcontrib>Celik, Onder</creatorcontrib><creatorcontrib>Celik, Nilufer</creatorcontrib><creatorcontrib>Turkcuoglu, Ilgin</creatorcontrib><creatorcontrib>Yilmaz, Ercan</creatorcontrib><creatorcontrib>Karaer, Abdullah</creatorcontrib><creatorcontrib>Simsek, Yavuz</creatorcontrib><creatorcontrib>Celik, Ebru</creatorcontrib><creatorcontrib>Aydin, Suleyman</creatorcontrib><title>Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus</title><title>Endocrine</title><addtitle>Endocrine</addtitle><addtitle>Endocrine</addtitle><description>To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 ± 8.3 vs. 9.6 ± 5.9 ng/ml,
P
= 0.001) and nesfatin-1 levels were found lower (5.5 ± 8.1 vs. 8.1 ± 23.9 ng/ml,
P
= 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 ± 4.3 and 8.2 ± 1.9 ng/ml,
P
= 0.618) and nesfatin-1 levels (5.4 ± 4.0 and 6.2 ± 10.3 ng/ml,
P
= 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.</description><subject>Adult</subject><subject>Apelin</subject><subject>Biomarkers - blood</subject><subject>Birth Weight</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Diabetes</subject><subject>Diabetes, Gestational - blood</subject><subject>DNA-Binding Proteins - blood</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Fetal Blood - metabolism</subject><subject>Gestational Age</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Insulin - blood</subject><subject>Intercellular Signaling Peptides and Proteins - blood</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>multidisciplinary</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Original Article</subject><subject>Pilot Projects</subject><subject>Postpartum Period - blood</subject><subject>Pregnancy</subject><subject>Science</subject><issn>1355-008X</issn><issn>1559-0100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kLtOwzAUhi0EoqXwACzII4vh-JbEI6q4iUosILFZtuNUqdy4xAkSb4-rFEam48t3fv36ELqkcEMByttEGTAgQClRsixJdYTmVEqVXwCO85lLSQCqjxk6S2kDwBgrylM0yxO4KKo5elnGvsY2xFjjzqfGDG1HKDZdjc3Oh3zhBQ7-y4eE2w6vfRoyEjsTcN0a6wef8NaH0A5jOkcnjQnJXxzmAr0_3L8tn8jq9fF5ebcijgsxkFxQKd6oqmkMFSCFYMYUEqyE0gItOYjKycqV0jGwygJvvDdKFDVXzjrDF-h6yt318XPMjfS2TS6XMJ2PY9I0C6EKoOAZpRPq-phS7xu969ut6b8zpPcO9eRQ5xW9d6irvHN1iB_t1td_G7_SMsAmIOWvbu17vYljn5Wkf1J_AFi_es4</recordid><startdate>20120601</startdate><enddate>20120601</enddate><creator>Aslan, Mehmet</creator><creator>Celik, Onder</creator><creator>Celik, Nilufer</creator><creator>Turkcuoglu, Ilgin</creator><creator>Yilmaz, Ercan</creator><creator>Karaer, Abdullah</creator><creator>Simsek, Yavuz</creator><creator>Celik, Ebru</creator><creator>Aydin, Suleyman</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120601</creationdate><title>Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus</title><author>Aslan, Mehmet ; Celik, Onder ; Celik, Nilufer ; Turkcuoglu, Ilgin ; Yilmaz, Ercan ; Karaer, Abdullah ; Simsek, Yavuz ; Celik, Ebru ; Aydin, Suleyman</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-559993f98ffa1405442aa650b507b0173048c58c75c20b9b03feea946d39cbca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Apelin</topic><topic>Biomarkers - blood</topic><topic>Birth Weight</topic><topic>Calcium-Binding Proteins - blood</topic><topic>Diabetes</topic><topic>Diabetes, Gestational - blood</topic><topic>DNA-Binding Proteins - blood</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Fetal Blood - metabolism</topic><topic>Gestational Age</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Insulin - blood</topic><topic>Intercellular Signaling Peptides and Proteins - blood</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>multidisciplinary</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Original Article</topic><topic>Pilot Projects</topic><topic>Postpartum Period - blood</topic><topic>Pregnancy</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Aslan, Mehmet</creatorcontrib><creatorcontrib>Celik, Onder</creatorcontrib><creatorcontrib>Celik, Nilufer</creatorcontrib><creatorcontrib>Turkcuoglu, Ilgin</creatorcontrib><creatorcontrib>Yilmaz, Ercan</creatorcontrib><creatorcontrib>Karaer, Abdullah</creatorcontrib><creatorcontrib>Simsek, Yavuz</creatorcontrib><creatorcontrib>Celik, Ebru</creatorcontrib><creatorcontrib>Aydin, Suleyman</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Aslan, Mehmet</au><au>Celik, Onder</au><au>Celik, Nilufer</au><au>Turkcuoglu, Ilgin</au><au>Yilmaz, Ercan</au><au>Karaer, Abdullah</au><au>Simsek, Yavuz</au><au>Celik, Ebru</au><au>Aydin, Suleyman</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus</atitle><jtitle>Endocrine</jtitle><stitle>Endocrine</stitle><addtitle>Endocrine</addtitle><date>2012-06-01</date><risdate>2012</risdate><volume>41</volume><issue>3</issue><spage>424</spage><epage>429</epage><pages>424-429</pages><issn>1355-008X</issn><eissn>1559-0100</eissn><abstract>To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 ± 8.3 vs. 9.6 ± 5.9 ng/ml,
P
= 0.001) and nesfatin-1 levels were found lower (5.5 ± 8.1 vs. 8.1 ± 23.9 ng/ml,
P
= 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 ± 4.3 and 8.2 ± 1.9 ng/ml,
P
= 0.618) and nesfatin-1 levels (5.4 ± 4.0 and 6.2 ± 10.3 ng/ml,
P
= 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>22203468</pmid><doi>10.1007/s12020-011-9577-8</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-008X |
| ispartof | Endocrine, 2012-06, Vol.41 (3), p.424-429 |
| issn | 1355-008X 1559-0100 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1011190063 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Apelin Biomarkers - blood Birth Weight Calcium-Binding Proteins - blood Diabetes Diabetes, Gestational - blood DNA-Binding Proteins - blood Endocrinology Female Fetal Blood - metabolism Gestational Age Humanities and Social Sciences Humans Infant, Newborn Insulin - blood Intercellular Signaling Peptides and Proteins - blood Internal Medicine Male Medicine Medicine & Public Health multidisciplinary Nerve Tissue Proteins - blood Original Article Pilot Projects Postpartum Period - blood Pregnancy Science |
| title | Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T20%3A31%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cord%20blood%20nesfatin-1%20and%20apelin-36%20levels%20in%20gestational%20diabetes%20mellitus&rft.jtitle=Endocrine&rft.au=Aslan,%20Mehmet&rft.date=2012-06-01&rft.volume=41&rft.issue=3&rft.spage=424&rft.epage=429&rft.pages=424-429&rft.issn=1355-008X&rft.eissn=1559-0100&rft_id=info:doi/10.1007/s12020-011-9577-8&rft_dat=%3Cproquest_cross%3E1011190063%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1011190063&rft_id=info:pmid/22203468&rfr_iscdi=true |