The effect of anti-Anisakis simplex antibody levels on C3 and C4 complement components in human sera
Previously, an in vitro effect was observed on the complement system not only of the excretory-secretory products but also of somatic antigens from L3 Anisakis simplex larvae. In the present work the effect of anti-A. simplex specific antibodies on C3 and C4 levels in human sera was investigated. Up...
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| Veröffentlicht in: | Journal of helminthology 2012-06, Vol.86 (2), p.197-201 |
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| container_title | Journal of helminthology |
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| creator | García-Hernández, P. Rodero, M. Gisbert-Criado, R. Puente, P. Pelayo, V. Andreu-Ballester, J.C. Cuéllar, C. |
| description | Previously, an in vitro effect was observed on the complement system not only of the excretory-secretory products but also of somatic antigens from L3 Anisakis simplex larvae. In the present work the effect of anti-A. simplex specific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-A. simplex antibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-A. simplex positive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-A. simplex antibodies and C3 and C4 deficiency was demonstrated. |
| doi_str_mv | 10.1017/S0022149X11000241 |
| format | Article |
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In the present work the effect of anti-A. simplex specific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-A. simplex antibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-A. simplex positive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-A. simplex antibodies and C3 and C4 deficiency was demonstrated.</description><identifier>ISSN: 0022-149X</identifier><identifier>EISSN: 1475-2697</identifier><identifier>DOI: 10.1017/S0022149X11000241</identifier><identifier>PMID: 21729389</identifier><identifier>CODEN: JOHLAT</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Animals ; Anisakiasis - immunology ; Anisakis - immunology ; Antibodies, Helminth - blood ; Biological and medical sciences ; Complement C3 - analysis ; Complement C3 - deficiency ; Complement C4 - analysis ; Female ; Fundamental and applied biological sciences. Psychology ; Host parasite relation; pathogenicity ; Humans ; Immunoglobulin A - blood ; Immunoglobulin E - blood ; Immunoglobulin G - blood ; Immunoglobulin M - blood ; Invertebrates ; Male ; Middle Aged ; Nemathelminthia. Plathelmintha</subject><ispartof>Journal of helminthology, 2012-06, Vol.86 (2), p.197-201</ispartof><rights>Copyright © Cambridge University Press 2011</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-8d70be1fa9abd50340d702a893955d3f0ec76fc45d547a7f1ea84c177939ecbc3</citedby><cites>FETCH-LOGICAL-c403t-8d70be1fa9abd50340d702a893955d3f0ec76fc45d547a7f1ea84c177939ecbc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0022149X11000241/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,315,782,786,27933,27934,55637</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25849714$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21729389$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Hernández, P.</creatorcontrib><creatorcontrib>Rodero, M.</creatorcontrib><creatorcontrib>Gisbert-Criado, R.</creatorcontrib><creatorcontrib>Puente, P.</creatorcontrib><creatorcontrib>Pelayo, V.</creatorcontrib><creatorcontrib>Andreu-Ballester, J.C.</creatorcontrib><creatorcontrib>Cuéllar, C.</creatorcontrib><title>The effect of anti-Anisakis simplex antibody levels on C3 and C4 complement components in human sera</title><title>Journal of helminthology</title><addtitle>J Helminthol</addtitle><description>Previously, an in vitro effect was observed on the complement system not only of the excretory-secretory products but also of somatic antigens from L3 Anisakis simplex larvae. In the present work the effect of anti-A. simplex specific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-A. simplex antibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-A. simplex positive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-A. simplex antibodies and C3 and C4 deficiency was demonstrated.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Animals</subject><subject>Anisakiasis - immunology</subject><subject>Anisakis - immunology</subject><subject>Antibodies, Helminth - blood</subject><subject>Biological and medical sciences</subject><subject>Complement C3 - analysis</subject><subject>Complement C3 - deficiency</subject><subject>Complement C4 - analysis</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Host parasite relation; pathogenicity</subject><subject>Humans</subject><subject>Immunoglobulin A - blood</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin G - blood</subject><subject>Immunoglobulin M - blood</subject><subject>Invertebrates</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nemathelminthia. 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In the present work the effect of anti-A. simplex specific antibodies on C3 and C4 levels in human sera was investigated. Up to 309 samples of sera were tested to determine levels of C3 and C4 and anti-A. simplex antibodies, including immunoglobulins IgG, IgM, IgA and IgE. Significant differences were observed between levels of C3 and C4 and all immunoglobulins except for IgE. In the case of immunoglobulins, the probability that an anti-A. simplex positive subject has a C3 deficiency was 3.8 times higher than a subject without specific antibodies. In conclusion, an association between elevated levels of anti-A. simplex antibodies and C3 and C4 deficiency was demonstrated.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>21729389</pmid><doi>10.1017/S0022149X11000241</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of helminthology, 2012-06, Vol.86 (2), p.197-201 |
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| language | eng |
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| subjects | Adult Aged Aged, 80 and over Animals Anisakiasis - immunology Anisakis - immunology Antibodies, Helminth - blood Biological and medical sciences Complement C3 - analysis Complement C3 - deficiency Complement C4 - analysis Female Fundamental and applied biological sciences. Psychology Host parasite relation pathogenicity Humans Immunoglobulin A - blood Immunoglobulin E - blood Immunoglobulin G - blood Immunoglobulin M - blood Invertebrates Male Middle Aged Nemathelminthia. Plathelmintha |
| title | The effect of anti-Anisakis simplex antibody levels on C3 and C4 complement components in human sera |
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