Nuclear architecture by RNA

Nuclear architecture by RNA

The dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important determinant of cell function. Recent studies point to a crucial role of RNA as an architectural factor for shaping the genome and its nuclear environment. Here, we outline ge...

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Veröffentlicht in:Current opinion in genetics & development 2012-04, Vol.22 (2), p.179-187
Hauptverfasser: Caudron-Herger, Maïwen, Rippe, Karsten
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Nucleus - genetics
Cell Nucleus - metabolism
Chromosomes
Genome
Humans
Medical Education
RNA - genetics
RNA - metabolism
Transcription, Genetic
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creator Caudron-Herger, Maïwen
Rippe, Karsten
description The dynamic organization of the cell nucleus into subcompartments with distinct biological activities represents an important determinant of cell function. Recent studies point to a crucial role of RNA as an architectural factor for shaping the genome and its nuclear environment. Here, we outline general principles by which RNA organizes functionally different nuclear subcompartments in mammalian cells. RNA is a structural component of mobile DNA-free nuclear bodies like paraspeckles or Cajal bodies, and is involved in establishing specific chromatin domains. The latter group comprises largely different structures that require RNA for the formation of active or repressive chromatin compartments with respect to gene expression as well as separating boundaries between these.
doi_str_mv 10.1016/j.gde.2011.12.005
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subjects Animals
Cell Nucleus - genetics
Cell Nucleus - metabolism
Chromosomes
Genome
Humans
Medical Education
RNA - genetics
RNA - metabolism
Transcription, Genetic
title Nuclear architecture by RNA
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