Langerhans cells down-regulate inflammation-driven alveolar bone loss

Excessive bone resorption is frequently associated with chronic infections and inflammatory diseases. Whereas T cells were demonstrated to facilitate osteoclastogenesis in such diseases, the role of dendritic cells, the most potent activators of naive T cells, remains unclear. Using a model involvin...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-05, Vol.109 (18), p.7043-7048
Hauptverfasser:	Arizon, Moran, Nudel, Itay, Segev, Hadas, Mizraji, Gabriel, Elnekave, Mazal, Furmanov, Karina, Eli-Berchoer, Luba, Clausen, Björn E, Shapira, Lior, Wilensky, Asaf, Hovav, Avi-Hai
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveolar Bone Loss Alveolar Bone Loss - etiology Alveolar Bone Loss - immunology Alveolar Bone Loss - prevention & control Animal models Animals antigens Antigens, CD Antigens, CD - genetics Antigens, CD - immunology Bacteroidaceae Infections Bacteroidaceae Infections - complications Bacteroidaceae Infections - immunology Base Sequence Biological Sciences Bone (alveolar) Bone loss Bone resorption Bone turnover Bones CD4 antigen CD4-positive T-lymphocytes CD4-Positive T-Lymphocytes - immunology CD8 antigen CD8-positive T-lymphocytes Cell activation Cells Chronic infection classification complications Cytokines Data processing Dendritic cells Disease Models, Animal DNA Primers DNA Primers - genetics Down-Regulation Down-Regulation - immunology etiology Foxp3 protein gamma -Interferon Gene expression genetics Gingiva Heparin-binding EGF-like Growth Factor homeostasis Humans immunology Immunoregulation Infections Inflammation Inflammation - complications Inflammation - immunology Inflammatory diseases Intercellular Signaling Peptides and Proteins Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - immunology interferon-gamma Interferon-gamma - metabolism Interleukin 10 Interleukin 17 Interleukin-10 - metabolism Interleukin-17 - metabolism Langerhans cells Langerhans Cells - classification Langerhans Cells - immunology Lectins, C-Type Lectins, C-Type - genetics Lectins, C-Type - immunology Lymphocyte Activation Lymphocytes Lymphocytes B Lymphocytes T Mannose-Binding Lectins Mannose-Binding Lectins - genetics Mannose-Binding Lectins - immunology metabolism Mice Mice, Inbred C57BL Mice, Transgenic Natural killer T cells NF- Kappa B protein Osteoclastogenesis Periodontitis Porphyromonas gingivalis Porphyromonas gingivalis - immunology prevention & control Proteins RANK Ligand RANK Ligand - metabolism Rodents secretion T lymphocytes T-Lymphocytes, Regulatory T-Lymphocytes, Regulatory - immunology
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