Human adipose tissue-derived mesenchymal stem cells protect kidneys from cisplatin nephrotoxicity in rats

Cisplatin has multiple cellular targets and modes of action that lead to nephrotoxicity. This suggests novel therapies that act at multiple cisplatin target sites may be effective. We tested whether human adipose tissue-derived mesenchymal stem cells (Ad-MSCs) can affect multiple target sites and pr...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2012-05, Vol.302 (9), p.F1141-F1150
Hauptverfasser:	Kim, Jin Hyun, Park, Dong Jun, Yun, Ji Chul, Jung, Myeong Hee, Yeo, Hee Dong, Kim, Hyun-Jung, Kim, Dong Wook, Yang, Jung Ill, Lee, Gyeong-Won, Jeong, Sang-Ho, Roh, Gu Seob, Chang, Se-Ho
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Kidney Injury - chemically induced Acute Kidney Injury - pathology Acute Kidney Injury - prevention & control Adipose Tissue - cytology Animals Apoptosis Apoptosis - physiology Cells, Cultured Cisplatin - adverse effects Extracellular Signal-Regulated MAP Kinases - metabolism Humans In Vitro Techniques Kidney - metabolism Kidney - pathology Kidney diseases Male MAP Kinase Kinase 4 - metabolism Mesenchymal Stem Cell Transplantation Mesenchymal Stromal Cells - cytology Models, Animal Molecules Phenotype Rats, Sprague-Dawley Rodents Signal Transduction Stem cells Toxicity Tumor Suppressor Protein p53 - metabolism
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