Glucose: A vital toxin and potential utility of melatonin in protecting against the diabetic state

► Chronically-elevated blood glucose generates toxic reactive species. ► Nitro-oxidative stress damages biomolecules causing disease. ► Melatonin is a potent antioxidant and anti-inflammatory agent. ► Melatonin reduces the toxicity of elevated blood glucose levels. The molecular mechanisms including...

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Veröffentlicht in:	Molecular and cellular endocrinology 2012-02, Vol.349 (2), p.128-137
Hauptverfasser:	Korkmaz, Ahmet, Ma, Shuran, Topal, Turgut, Rosales-Corral, Sergio, Tan, Dun-Xian, Reiter, Russel J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation adipocytes Adipocytes - metabolism Adipocytes - pathology Animals anti-inflammatory activity Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology Antioxidants - metabolism Antioxidants - pharmacology Biomolecules blood glucose Blood Glucose - metabolism body weight Cellular cytokines Diabetes Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - physiopathology DNA epigenetics Glucose Glucose Transporter Type 4 - metabolism Glycosylation Humans Hyperglycemia Hyperglycemia - drug therapy Hyperglycemia - metabolism Hyperglycemia - physiopathology hyperlipidemia inflammation Inflammation - drug therapy Inflammation - metabolism Inflammation - physiopathology Insulin Insulin - metabolism Insulin Resistance lipids Melatonin Melatonin - metabolism Melatonin - pharmacology Melatonin - therapeutic use noninsulin-dependent diabetes mellitus Oxidative Stress - drug effects oxygen patients proteins Reactive Nitrogen Species - antagonists & inhibitors Reactive Nitrogen Species - metabolism Reactive Oxygen Species - antagonists & inhibitors Reactive Oxygen Species - metabolism Signal Transduction Toxicity transcription factors
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