Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process
► Nanoscale ursolic acid (UA) was made by a supercritical antisolvent process. ► Mean particle size of processed UA is 139.2±19.7nm, irregularly spherical. ► Dissolution rate and oral bioavailability of nanoscale UA increased significantly. The objective of the study was to prepare ursolic acid (UA)...
Gespeichert in:
| Veröffentlicht in: | Food chemistry 2012-05, Vol.132 (1), p.319-325 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 325 |
|---|---|
| container_issue | 1 |
| container_start_page | 319 |
| container_title | Food chemistry |
| container_volume | 132 |
| creator | Yang, Lei Sun, Zhen Zu, Yuangang Zhao, Chunjian Sun, Xiaowei Zhang, Zhonghua Zhang, Lin |
| description | ► Nanoscale ursolic acid (UA) was made by a supercritical antisolvent process. ► Mean particle size of processed UA is 139.2±19.7nm, irregularly spherical. ► Dissolution rate and oral bioavailability of nanoscale UA increased significantly.
The objective of the study was to prepare ursolic acid (UA) nanoparticles using the supercritical anti-solvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during SAS process, were investigated. Particles with mean particle size ranging from 139.2±19.7 to 1039.8±65.2nm were obtained by varying the process parameters. The UA was characterised by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, specific surface area, dissolution test and bioavailability test. It was concluded that physicochemical properties and bioavailability of crystalline UA could be improved by physical modification, such as particle size reduction and generation of amorphous state using SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of UA. |
| doi_str_mv | 10.1016/j.foodchem.2011.10.083 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1010895569</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0308814611015366</els_id><sourcerecordid>1010895569</sourcerecordid><originalsourceid>FETCH-LOGICAL-c497t-d0fc67ffe266f502f8229a9e0d4f61b0a706d61fda7cf959e3b1afe0d99c50623</originalsourceid><addsrcrecordid>eNqFkE1r3DAQhkVpaLZp_0LwpZAevJFkW7ZuDaFfEEgg7dnI0qiZxSttJXthb_3pHXc37bEnweh53xkexi4FXwsu1PVm7WN09gm2a8mFoOGad9ULthJdW5Utb-VLtuIV78pO1Oqcvc55wzkntnvFzqWqq1pqtWK_Hp4OGW1cmtCasdiluIM0IeTCBFfERLMBo9kbHM2AI06HIvpiTjmOaAtj0RXBhLgzFLIjxeaM4UeRZ6qxCac_rSZMWFJiD2Eqrh5vHt8viyzk_IadeTNmeHt6L9j3Tx-_3X4p7-4_f729uSttrdupdNxb1XoPUinfcOk7KbXRwF3tlRi4ablySnhnWut1o6EahPH0rbVtuJLVBbs69tLenzPkqd9itjCOJkCcc09WeaebRmlC1RG1KeacwPe7hFuTDgQtnOo3_bP9frG_zMk-BS9PO-ZhC-5v7Fk3Ae9OgMmkxScTLOZ_XKOl5p0g7sORAzKyR0h9tgjBgsMEdupdxP_d8hsfs6m_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1010895569</pqid></control><display><type>article</type><title>Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Yang, Lei ; Sun, Zhen ; Zu, Yuangang ; Zhao, Chunjian ; Sun, Xiaowei ; Zhang, Zhonghua ; Zhang, Lin</creator><creatorcontrib>Yang, Lei ; Sun, Zhen ; Zu, Yuangang ; Zhao, Chunjian ; Sun, Xiaowei ; Zhang, Zhonghua ; Zhang, Lin</creatorcontrib><description>► Nanoscale ursolic acid (UA) was made by a supercritical antisolvent process. ► Mean particle size of processed UA is 139.2±19.7nm, irregularly spherical. ► Dissolution rate and oral bioavailability of nanoscale UA increased significantly.
The objective of the study was to prepare ursolic acid (UA) nanoparticles using the supercritical anti-solvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during SAS process, were investigated. Particles with mean particle size ranging from 139.2±19.7 to 1039.8±65.2nm were obtained by varying the process parameters. The UA was characterised by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, specific surface area, dissolution test and bioavailability test. It was concluded that physicochemical properties and bioavailability of crystalline UA could be improved by physical modification, such as particle size reduction and generation of amorphous state using SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of UA.</description><identifier>ISSN: 0308-8146</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2011.10.083</identifier><identifier>PMID: 26434296</identifier><identifier>CODEN: FOCHDJ</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Administration, Oral ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Chemical Phenomena ; Dissolution ; Drugs ; Feeding. Feeding behavior ; Flow rate ; Food industries ; Fundamental and applied biological sciences. Psychology ; Nanoparticles ; Nanoparticles - chemistry ; Process parameters ; SAS ; Solvents - chemistry ; Specific surface ; Supercritical anti-solvent process ; Triterpenes - chemistry ; Ursolic Acid ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Food chemistry, 2012-05, Vol.132 (1), p.319-325</ispartof><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-d0fc67ffe266f502f8229a9e0d4f61b0a706d61fda7cf959e3b1afe0d99c50623</citedby><cites>FETCH-LOGICAL-c497t-d0fc67ffe266f502f8229a9e0d4f61b0a706d61fda7cf959e3b1afe0d99c50623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2011.10.083$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25929081$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26434296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Sun, Zhen</creatorcontrib><creatorcontrib>Zu, Yuangang</creatorcontrib><creatorcontrib>Zhao, Chunjian</creatorcontrib><creatorcontrib>Sun, Xiaowei</creatorcontrib><creatorcontrib>Zhang, Zhonghua</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><title>Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>► Nanoscale ursolic acid (UA) was made by a supercritical antisolvent process. ► Mean particle size of processed UA is 139.2±19.7nm, irregularly spherical. ► Dissolution rate and oral bioavailability of nanoscale UA increased significantly.
The objective of the study was to prepare ursolic acid (UA) nanoparticles using the supercritical anti-solvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during SAS process, were investigated. Particles with mean particle size ranging from 139.2±19.7 to 1039.8±65.2nm were obtained by varying the process parameters. The UA was characterised by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, specific surface area, dissolution test and bioavailability test. It was concluded that physicochemical properties and bioavailability of crystalline UA could be improved by physical modification, such as particle size reduction and generation of amorphous state using SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of UA.</description><subject>Administration, Oral</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Chemical Phenomena</subject><subject>Dissolution</subject><subject>Drugs</subject><subject>Feeding. Feeding behavior</subject><subject>Flow rate</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Process parameters</subject><subject>SAS</subject><subject>Solvents - chemistry</subject><subject>Specific surface</subject><subject>Supercritical anti-solvent process</subject><subject>Triterpenes - chemistry</subject><subject>Ursolic Acid</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0308-8146</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1r3DAQhkVpaLZp_0LwpZAevJFkW7ZuDaFfEEgg7dnI0qiZxSttJXthb_3pHXc37bEnweh53xkexi4FXwsu1PVm7WN09gm2a8mFoOGad9ULthJdW5Utb-VLtuIV78pO1Oqcvc55wzkntnvFzqWqq1pqtWK_Hp4OGW1cmtCasdiluIM0IeTCBFfERLMBo9kbHM2AI06HIvpiTjmOaAtj0RXBhLgzFLIjxeaM4UeRZ6qxCac_rSZMWFJiD2Eqrh5vHt8viyzk_IadeTNmeHt6L9j3Tx-_3X4p7-4_f729uSttrdupdNxb1XoPUinfcOk7KbXRwF3tlRi4ablySnhnWut1o6EahPH0rbVtuJLVBbs69tLenzPkqd9itjCOJkCcc09WeaebRmlC1RG1KeacwPe7hFuTDgQtnOo3_bP9frG_zMk-BS9PO-ZhC-5v7Fk3Ae9OgMmkxScTLOZ_XKOl5p0g7sORAzKyR0h9tgjBgsMEdupdxP_d8hsfs6m_</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Yang, Lei</creator><creator>Sun, Zhen</creator><creator>Zu, Yuangang</creator><creator>Zhao, Chunjian</creator><creator>Sun, Xiaowei</creator><creator>Zhang, Zhonghua</creator><creator>Zhang, Lin</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QQ</scope><scope>8FD</scope><scope>F28</scope><scope>FR3</scope><scope>JG9</scope></search><sort><creationdate>20120501</creationdate><title>Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process</title><author>Yang, Lei ; Sun, Zhen ; Zu, Yuangang ; Zhao, Chunjian ; Sun, Xiaowei ; Zhang, Zhonghua ; Zhang, Lin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-d0fc67ffe266f502f8229a9e0d4f61b0a706d61fda7cf959e3b1afe0d99c50623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Administration, Oral</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Chemical Phenomena</topic><topic>Dissolution</topic><topic>Drugs</topic><topic>Feeding. Feeding behavior</topic><topic>Flow rate</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Process parameters</topic><topic>SAS</topic><topic>Solvents - chemistry</topic><topic>Specific surface</topic><topic>Supercritical anti-solvent process</topic><topic>Triterpenes - chemistry</topic><topic>Ursolic Acid</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Lei</creatorcontrib><creatorcontrib>Sun, Zhen</creatorcontrib><creatorcontrib>Zu, Yuangang</creatorcontrib><creatorcontrib>Zhao, Chunjian</creatorcontrib><creatorcontrib>Sun, Xiaowei</creatorcontrib><creatorcontrib>Zhang, Zhonghua</creatorcontrib><creatorcontrib>Zhang, Lin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Ceramic Abstracts</collection><collection>Technology Research Database</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Lei</au><au>Sun, Zhen</au><au>Zu, Yuangang</au><au>Zhao, Chunjian</au><au>Sun, Xiaowei</au><au>Zhang, Zhonghua</au><au>Zhang, Lin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>132</volume><issue>1</issue><spage>319</spage><epage>325</epage><pages>319-325</pages><issn>0308-8146</issn><eissn>1873-7072</eissn><coden>FOCHDJ</coden><abstract>► Nanoscale ursolic acid (UA) was made by a supercritical antisolvent process. ► Mean particle size of processed UA is 139.2±19.7nm, irregularly spherical. ► Dissolution rate and oral bioavailability of nanoscale UA increased significantly.
The objective of the study was to prepare ursolic acid (UA) nanoparticles using the supercritical anti-solvent (SAS) process and evaluate its physicochemical properties and oral bioavailability. The effects of four process variables, pressure, temperature, drug concentration and drug solution flow rate, on drug particle formation during SAS process, were investigated. Particles with mean particle size ranging from 139.2±19.7 to 1039.8±65.2nm were obtained by varying the process parameters. The UA was characterised by scanning electron microscopy, X-ray diffraction, Fourier-transform infrared spectroscopy, thermal gravimetric analysis, specific surface area, dissolution test and bioavailability test. It was concluded that physicochemical properties and bioavailability of crystalline UA could be improved by physical modification, such as particle size reduction and generation of amorphous state using SAS process. Further, SAS process was a powerful methodology for improving the physicochemical properties and bioavailability of UA.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>26434296</pmid><doi>10.1016/j.foodchem.2011.10.083</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0308-8146 |
| ispartof | Food chemistry, 2012-05, Vol.132 (1), p.319-325 |
| issn | 0308-8146 1873-7072 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1010895569 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Administration, Oral Bioavailability Biological and medical sciences Biological Availability Chemical Phenomena Dissolution Drugs Feeding. Feeding behavior Flow rate Food industries Fundamental and applied biological sciences. Psychology Nanoparticles Nanoparticles - chemistry Process parameters SAS Solvents - chemistry Specific surface Supercritical anti-solvent process Triterpenes - chemistry Ursolic Acid Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Physicochemical properties and oral bioavailability of ursolic acid nanoparticles using supercritical anti-solvent (SAS) process |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T16%3A30%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Physicochemical%20properties%20and%20oral%20bioavailability%20of%20ursolic%20acid%20nanoparticles%20using%20supercritical%20anti-solvent%20(SAS)%20process&rft.jtitle=Food%20chemistry&rft.au=Yang,%20Lei&rft.date=2012-05-01&rft.volume=132&rft.issue=1&rft.spage=319&rft.epage=325&rft.pages=319-325&rft.issn=0308-8146&rft.eissn=1873-7072&rft.coden=FOCHDJ&rft_id=info:doi/10.1016/j.foodchem.2011.10.083&rft_dat=%3Cproquest_cross%3E1010895569%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1010895569&rft_id=info:pmid/26434296&rft_els_id=S0308814611015366&rfr_iscdi=true |