Development of novel self-assembled poly(3-acrylamidophenylboronic acid)/poly(2-lactobionamidoethyl methacrylate) hybrid nanoparticles for improving nasal adsorption of insulin

It is well-known that the phenylboronic acid derivatives have chemical interactions with sugars. Hence, stable nanoparticles with core-shell structure were formed by the covalent complexation between boronic acid groups of poly(3-acrylamidophenylboronic acid) (pAPBA) and hydroxyl groups of poly(2-la...

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Veröffentlicht in:Soft matter 2012-01, Vol.8 (3), p.765-773
Hauptverfasser: Cheng, Cui, Zhang, Xinge, Xiang, Jixin, Wang, Yanxia, Zheng, Chao, Lu, Zhentan, Li, Chaoxing
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Sprache:eng
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