Safety, tolerability, and pharmacokinetics of a single dose of pasireotide long-acting release in healthy volunteers: a single-center Phase I study

ObjectiveThis study was conducted to evaluate the safety, tolerability, and pharmacokinetics (PKs) of different doses of a long-acting release (LAR) formulation of pasireotide in healthy subjects.DesignSingle-center, open-label, randomized Phase I study.MethodsTwelve healthy male subjects received a...

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Veröffentlicht in:	European journal of endocrinology 2012-05, Vol.166 (5), p.821-828
Hauptverfasser:	Dietrich, Hartmut, Hu, Ke, Ruffin, Matthieu, Song, Dongweon, Bouillaud, Emmanuel, Wang, Yanfeng, Hasskarl, Jens
Format:	Artikel
Sprache:	eng
Schlagworte:	Abdominal Pain - blood Abdominal Pain - chemically induced Adolescent Adult Biological and medical sciences Clinical Study Delayed-Action Preparations - administration & dosage Delayed-Action Preparations - adverse effects Delayed-Action Preparations - pharmacokinetics Diarrhea - blood Diarrhea - chemically induced Endocrinopathies Fundamental and applied biological sciences. Psychology Humans Male Medical sciences Somatostatin - administration & dosage Somatostatin - adverse effects Somatostatin - analogs & derivatives Somatostatin - pharmacokinetics Vertebrates: endocrinology Young Adult
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