Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

Key Points This Review chronicles the events that led to an increased understanding of osteoclast biology, the identification of osteoprotegerin (OPG) and the signalling pathway mediated by receptor activator of NF-κB (RANK) and RANK ligand (RANKL), as well as the development of the therapeutic RANK...

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