The conversion of oridonin to spirolactone-type or enmein-type diterpenoid: Synthesis and biological evaluation of ent-6,7-seco-oridonin derivatives as novel potential anticancer agents

Starting from commercial available natural product oridonin (1), a practical synthesis of ent-6,7-seco-oridonin derivatives (2, 3, 5, and 9) was accomplished and their biological activities were evaluated. The conversion of spirolactone-type diterpenoid to enmein-type was first completed. The result...

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Veröffentlicht in:	European journal of medicinal chemistry 2012-06, Vol.52, p.242-250
Hauptverfasser:	Wang, Lei, Li, Dahong, Xu, Shengtao, Cai, Hao, Yao, Hequan, Zhang, Yihua, Jiang, Jieyun, Xu, Jinyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-tumor activity Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Biological and medical sciences Chemistry Techniques, Synthetic Cytotoxicity Diterpenes - chemistry Diterpenes, Kaurane - chemical synthesis Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - pharmacology Enmein-type diterpenoid ent-6,7-seco-Oridonin derivatives Female Humans K562 Cells Medical sciences Mice Miscellaneous Pharmacology. Drug treatments Spirolactone-type diterpenoid Spironolactone - chemistry Structure-Activity Relationship Xenograft Model Antitumor Assays
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