A System of Repressor Gradients Spatially Organizes the Boundaries of Bicoid-Dependent Target Genes

The homeodomain (HD) protein Bicoid (Bcd) is thought to function as a gradient morphogen that positions boundaries of target genes via threshold-dependent activation mechanisms. Here, we analyze 66 Bcd-dependent regulatory elements and show that their boundaries are positioned primarily by repressiv...

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Veröffentlicht in:	Cell 2012-04, Vol.149 (3), p.618-629
Hauptverfasser:	Chen, Hongtao, Xu, Zhe, Mei, Constance, Yu, Danyang, Small, Stephen
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Patterning DNA-Binding Proteins - metabolism Drosophila melanogaster - embryology Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - metabolism embryo (animal) Enhancer Elements, Genetic Gene Expression Regulation, Developmental genes GTPase-activating proteins homeodomain proteins Homeodomain Proteins - metabolism morphogenesis Nuclear Proteins - metabolism Trans-Activators - metabolism Transcription Factors - metabolism
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