Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children
Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circula...
Gespeichert in:
| Veröffentlicht in: | Clinical chemistry (Baltimore, Md.) Md.), 2012-05, Vol.58 (5), p.854-868 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 868 |
|---|---|
| container_issue | 5 |
| container_start_page | 854 |
| container_title | Clinical chemistry (Baltimore, Md.) |
| container_volume | 58 |
| creator | COLANTONIO, David A KYRIAKOPOULOU, Lianna KHUN CHAN, Man DALY, Caitlin H BRINE, Davor VENNER, Allison A PASIC, Maria D ARMBRUSTER, David ADELI, Khosrow |
| description | Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.
Healthy children and adolescents (n = 2188, newborn to 18 years of age) were recruited from a multiethnic population with informed parental consent and were assessed from completed questionnaires and according to defined exclusion criteria. Whole-blood samples were collected for establishing age- and sex-stratified reference intervals for 40 serum biochemical markers (serum chemistry, enzymes, lipids, proteins) on the Abbott ARCHITECT c8000 analyzer.
Reference intervals were generated according to CLSI C28-A3 statistical guidelines. Caucasians, East Asians, and South Asian participants were evaluated with respect to the influence of ethnicity, and statistically significant differences were observed for 7 specific biomarkers.
The establishment of a new comprehensive database of pediatric reference intervals is part of the Canadian Laboratory Initiative in Pediatric Reference Intervals (CALIPER). It should assist laboratorians and pediatricians in interpreting test results more accurately and thereby lead to improved diagnosis of childhood diseases and reduced patient risk. The database will also be of global benefit once reference intervals are validated in transference studies with other analytical platforms and local populations, as recommended by the CLSI. |
| doi_str_mv | 10.1373/clinchem.2011.177741 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1010476506</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1010476506</sourcerecordid><originalsourceid>FETCH-LOGICAL-c477t-6fa7ab0abcc6c72c3a826c38217336a6e7b334b83f3ff187b4d97f8b93ba0e413</originalsourceid><addsrcrecordid>eNpdkdGKEzEUhoMobl19A5GACHszNZlMJzPerd11t9DFsuj1cJI5cbJOk5pkhL6Mz2pquwpehcB3_v9wPkJeczbnQor3erROD7idl4zzOZdSVvwJmfGFYEWzqPlTMmOMtUXLK3lGXsT4kL-VbOrn5KwsheRVU87Ir-Xoo3XfaBqQ3sAuUuvoBnsLKVhN16B8gOTDnt6jwYBOI125hOEnjPEDvaTLy_Vqc31PryCBgojUG1ox-tH6w3JWw0jvIHzH8CcZ6C3CmIY9BdfTu2lMFtPgctPG76YRkvXukLAc7NjntpfkmclF-Or0npOvn66_LG-L9eebVa4udCVlKmoDEhQDpXWtZakFNGWtRVNyKUQNNUolRKUaYYQxvJGq6ltpGtUKBQwrLs7JxTF3F_yPCWPqtjZqHEdw6KfYccbz7eoFqzP69j_0wU_B5e0ylV3UTa7NVHWkdPAxBjTdLtgthH2GuoO_7tFfd_DXHf3lsTen8Eltsf879CgsA-9OAMR8WxPAaRv_cYuGt23JxG9tIaUk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020168821</pqid></control><display><type>article</type><title>Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><creator>COLANTONIO, David A ; KYRIAKOPOULOU, Lianna ; KHUN CHAN, Man ; DALY, Caitlin H ; BRINE, Davor ; VENNER, Allison A ; PASIC, Maria D ; ARMBRUSTER, David ; ADELI, Khosrow</creator><creatorcontrib>COLANTONIO, David A ; KYRIAKOPOULOU, Lianna ; KHUN CHAN, Man ; DALY, Caitlin H ; BRINE, Davor ; VENNER, Allison A ; PASIC, Maria D ; ARMBRUSTER, David ; ADELI, Khosrow</creatorcontrib><description>Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.
Healthy children and adolescents (n = 2188, newborn to 18 years of age) were recruited from a multiethnic population with informed parental consent and were assessed from completed questionnaires and according to defined exclusion criteria. Whole-blood samples were collected for establishing age- and sex-stratified reference intervals for 40 serum biochemical markers (serum chemistry, enzymes, lipids, proteins) on the Abbott ARCHITECT c8000 analyzer.
Reference intervals were generated according to CLSI C28-A3 statistical guidelines. Caucasians, East Asians, and South Asian participants were evaluated with respect to the influence of ethnicity, and statistically significant differences were observed for 7 specific biomarkers.
The establishment of a new comprehensive database of pediatric reference intervals is part of the Canadian Laboratory Initiative in Pediatric Reference Intervals (CALIPER). It should assist laboratorians and pediatricians in interpreting test results more accurately and thereby lead to improved diagnosis of childhood diseases and reduced patient risk. The database will also be of global benefit once reference intervals are validated in transference studies with other analytical platforms and local populations, as recommended by the CLSI.</description><identifier>ISSN: 0009-9147</identifier><identifier>EISSN: 1530-8561</identifier><identifier>DOI: 10.1373/clinchem.2011.177741</identifier><identifier>PMID: 22371482</identifier><identifier>CODEN: CLCHAU</identifier><language>eng</language><publisher>Washington, DC: American Association for Clinical Chemistry</publisher><subject>Adolescent ; Age Factors ; Analytical, structural and metabolic biochemistry ; Architects ; Asian Continental Ancestry Group ; Biological and medical sciences ; Biomarkers - blood ; Canada ; Child ; Child, Preschool ; Children & youth ; Databases, Factual ; Ethnicity ; European Continental Ancestry Group ; Female ; Fundamental and applied biological sciences. Psychology ; Gender differences ; Hospitals ; Humans ; Hypothyroidism ; Infant ; Infant, Newborn ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical research ; Medical sciences ; Metabolic disorders ; Molecular biophysics ; Nutrition research ; Pediatrics ; Reference Values ; Schools ; Sex Factors</subject><ispartof>Clinical chemistry (Baltimore, Md.), 2012-05, Vol.58 (5), p.854-868</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright American Association for Clinical Chemistry May 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c477t-6fa7ab0abcc6c72c3a826c38217336a6e7b334b83f3ff187b4d97f8b93ba0e413</citedby><cites>FETCH-LOGICAL-c477t-6fa7ab0abcc6c72c3a826c38217336a6e7b334b83f3ff187b4d97f8b93ba0e413</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25819920$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22371482$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COLANTONIO, David A</creatorcontrib><creatorcontrib>KYRIAKOPOULOU, Lianna</creatorcontrib><creatorcontrib>KHUN CHAN, Man</creatorcontrib><creatorcontrib>DALY, Caitlin H</creatorcontrib><creatorcontrib>BRINE, Davor</creatorcontrib><creatorcontrib>VENNER, Allison A</creatorcontrib><creatorcontrib>PASIC, Maria D</creatorcontrib><creatorcontrib>ARMBRUSTER, David</creatorcontrib><creatorcontrib>ADELI, Khosrow</creatorcontrib><title>Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children</title><title>Clinical chemistry (Baltimore, Md.)</title><addtitle>Clin Chem</addtitle><description>Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.
Healthy children and adolescents (n = 2188, newborn to 18 years of age) were recruited from a multiethnic population with informed parental consent and were assessed from completed questionnaires and according to defined exclusion criteria. Whole-blood samples were collected for establishing age- and sex-stratified reference intervals for 40 serum biochemical markers (serum chemistry, enzymes, lipids, proteins) on the Abbott ARCHITECT c8000 analyzer.
Reference intervals were generated according to CLSI C28-A3 statistical guidelines. Caucasians, East Asians, and South Asian participants were evaluated with respect to the influence of ethnicity, and statistically significant differences were observed for 7 specific biomarkers.
The establishment of a new comprehensive database of pediatric reference intervals is part of the Canadian Laboratory Initiative in Pediatric Reference Intervals (CALIPER). It should assist laboratorians and pediatricians in interpreting test results more accurately and thereby lead to improved diagnosis of childhood diseases and reduced patient risk. The database will also be of global benefit once reference intervals are validated in transference studies with other analytical platforms and local populations, as recommended by the CLSI.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Architects</subject><subject>Asian Continental Ancestry Group</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Canada</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Databases, Factual</subject><subject>Ethnicity</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gender differences</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Metabolic disorders</subject><subject>Molecular biophysics</subject><subject>Nutrition research</subject><subject>Pediatrics</subject><subject>Reference Values</subject><subject>Schools</subject><subject>Sex Factors</subject><issn>0009-9147</issn><issn>1530-8561</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkdGKEzEUhoMobl19A5GACHszNZlMJzPerd11t9DFsuj1cJI5cbJOk5pkhL6Mz2pquwpehcB3_v9wPkJeczbnQor3erROD7idl4zzOZdSVvwJmfGFYEWzqPlTMmOMtUXLK3lGXsT4kL-VbOrn5KwsheRVU87Ir-Xoo3XfaBqQ3sAuUuvoBnsLKVhN16B8gOTDnt6jwYBOI125hOEnjPEDvaTLy_Vqc31PryCBgojUG1ox-tH6w3JWw0jvIHzH8CcZ6C3CmIY9BdfTu2lMFtPgctPG76YRkvXukLAc7NjntpfkmclF-Or0npOvn66_LG-L9eebVa4udCVlKmoDEhQDpXWtZakFNGWtRVNyKUQNNUolRKUaYYQxvJGq6ltpGtUKBQwrLs7JxTF3F_yPCWPqtjZqHEdw6KfYccbz7eoFqzP69j_0wU_B5e0ylV3UTa7NVHWkdPAxBjTdLtgthH2GuoO_7tFfd_DXHf3lsTen8Eltsf879CgsA-9OAMR8WxPAaRv_cYuGt23JxG9tIaUk</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>COLANTONIO, David A</creator><creator>KYRIAKOPOULOU, Lianna</creator><creator>KHUN CHAN, Man</creator><creator>DALY, Caitlin H</creator><creator>BRINE, Davor</creator><creator>VENNER, Allison A</creator><creator>PASIC, Maria D</creator><creator>ARMBRUSTER, David</creator><creator>ADELI, Khosrow</creator><general>American Association for Clinical Chemistry</general><general>Oxford University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4U-</scope><scope>7QO</scope><scope>7RV</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PCBAR</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children</title><author>COLANTONIO, David A ; KYRIAKOPOULOU, Lianna ; KHUN CHAN, Man ; DALY, Caitlin H ; BRINE, Davor ; VENNER, Allison A ; PASIC, Maria D ; ARMBRUSTER, David ; ADELI, Khosrow</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c477t-6fa7ab0abcc6c72c3a826c38217336a6e7b334b83f3ff187b4d97f8b93ba0e413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Architects</topic><topic>Asian Continental Ancestry Group</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Canada</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Databases, Factual</topic><topic>Ethnicity</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gender differences</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Metabolic disorders</topic><topic>Molecular biophysics</topic><topic>Nutrition research</topic><topic>Pediatrics</topic><topic>Reference Values</topic><topic>Schools</topic><topic>Sex Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COLANTONIO, David A</creatorcontrib><creatorcontrib>KYRIAKOPOULOU, Lianna</creatorcontrib><creatorcontrib>KHUN CHAN, Man</creatorcontrib><creatorcontrib>DALY, Caitlin H</creatorcontrib><creatorcontrib>BRINE, Davor</creatorcontrib><creatorcontrib>VENNER, Allison A</creatorcontrib><creatorcontrib>PASIC, Maria D</creatorcontrib><creatorcontrib>ARMBRUSTER, David</creatorcontrib><creatorcontrib>ADELI, Khosrow</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>University Readers</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COLANTONIO, David A</au><au>KYRIAKOPOULOU, Lianna</au><au>KHUN CHAN, Man</au><au>DALY, Caitlin H</au><au>BRINE, Davor</au><au>VENNER, Allison A</au><au>PASIC, Maria D</au><au>ARMBRUSTER, David</au><au>ADELI, Khosrow</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children</atitle><jtitle>Clinical chemistry (Baltimore, Md.)</jtitle><addtitle>Clin Chem</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>58</volume><issue>5</issue><spage>854</spage><epage>868</epage><pages>854-868</pages><issn>0009-9147</issn><eissn>1530-8561</eissn><coden>CLCHAU</coden><abstract>Pediatric healthcare is critically dependent on the availability of accurate and precise laboratory biomarkers of pediatric disease, and on the availability of reference intervals to allow appropriate clinical interpretation. The development and growth of children profoundly influence normal circulating concentrations of biochemical markers and thus the respective reference intervals. There are currently substantial gaps in our knowledge of the influences of age, sex, and ethnicity on reference intervals. We report a comprehensive covariate-stratified reference interval database established from a healthy, nonhospitalized, and multiethnic pediatric population.
Healthy children and adolescents (n = 2188, newborn to 18 years of age) were recruited from a multiethnic population with informed parental consent and were assessed from completed questionnaires and according to defined exclusion criteria. Whole-blood samples were collected for establishing age- and sex-stratified reference intervals for 40 serum biochemical markers (serum chemistry, enzymes, lipids, proteins) on the Abbott ARCHITECT c8000 analyzer.
Reference intervals were generated according to CLSI C28-A3 statistical guidelines. Caucasians, East Asians, and South Asian participants were evaluated with respect to the influence of ethnicity, and statistically significant differences were observed for 7 specific biomarkers.
The establishment of a new comprehensive database of pediatric reference intervals is part of the Canadian Laboratory Initiative in Pediatric Reference Intervals (CALIPER). It should assist laboratorians and pediatricians in interpreting test results more accurately and thereby lead to improved diagnosis of childhood diseases and reduced patient risk. The database will also be of global benefit once reference intervals are validated in transference studies with other analytical platforms and local populations, as recommended by the CLSI.</abstract><cop>Washington, DC</cop><pub>American Association for Clinical Chemistry</pub><pmid>22371482</pmid><doi>10.1373/clinchem.2011.177741</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9147 |
| ispartof | Clinical chemistry (Baltimore, Md.), 2012-05, Vol.58 (5), p.854-868 |
| issn | 0009-9147 1530-8561 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1010476506 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Adolescent Age Factors Analytical, structural and metabolic biochemistry Architects Asian Continental Ancestry Group Biological and medical sciences Biomarkers - blood Canada Child Child, Preschool Children & youth Databases, Factual Ethnicity European Continental Ancestry Group Female Fundamental and applied biological sciences. Psychology Gender differences Hospitals Humans Hypothyroidism Infant Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Male Medical research Medical sciences Metabolic disorders Molecular biophysics Nutrition research Pediatrics Reference Values Schools Sex Factors |
| title | Closing the Gaps in Pediatric Laboratory Reference Intervals: A CALIPER Database of 40 Biochemical Markers in a Healthy and Multiethnic Population of Children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T11%3A02%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Closing%20the%20Gaps%20in%20Pediatric%20Laboratory%20Reference%20Intervals:%20A%20CALIPER%20Database%20of%2040%20Biochemical%20Markers%20in%20a%20Healthy%20and%20Multiethnic%20Population%20of%20Children&rft.jtitle=Clinical%20chemistry%20(Baltimore,%20Md.)&rft.au=COLANTONIO,%20David%20A&rft.date=2012-05-01&rft.volume=58&rft.issue=5&rft.spage=854&rft.epage=868&rft.pages=854-868&rft.issn=0009-9147&rft.eissn=1530-8561&rft.coden=CLCHAU&rft_id=info:doi/10.1373/clinchem.2011.177741&rft_dat=%3Cproquest_cross%3E1010476506%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1020168821&rft_id=info:pmid/22371482&rfr_iscdi=true |