In Silico Drug Screen in Mouse Liver Identifies Candidate Calorie Restriction Mimetics

Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,0...

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Veröffentlicht in:	Rejuvenation research 2012-04, Vol.15 (2), p.148-152
Hauptverfasser:	Fortney, Kristen, Morgen, Eric K., Kotlyar, Max, Jurisica, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caloric Restriction - methods Cell Line Chromosome Mapping Computational Biology - methods Drug Evaluation, Preclinical Gene Expression Regulation Genome Genome, Human Humans Liver - drug effects Liver - metabolism Mice Oligonucleotide Array Sequence Analysis Original Articles Software Transcription, Genetic
Online-Zugang:	Volltext
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