In Silico Drug Screen in Mouse Liver Identifies Candidate Calorie Restriction Mimetics
Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,0...
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| Veröffentlicht in: | Rejuvenation research 2012-04, Vol.15 (2), p.148-152 |
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| container_title | Rejuvenation research |
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| creator | Fortney, Kristen Morgen, Eric K. Kotlyar, Max Jurisica, Igor |
| description | Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments have become available. Here we integrate these data with gene expression signatures of CR in mouse liver to generate a prioritized list of candidate CR mimetics. We identify 14 drugs that reproduce the effects of CR at the transcriptional level. |
| doi_str_mv | 10.1089/rej.2011.1263 |
| format | Article |
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| ispartof | Rejuvenation research, 2012-04, Vol.15 (2), p.148-152 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Caloric Restriction - methods Cell Line Chromosome Mapping Computational Biology - methods Drug Evaluation, Preclinical Gene Expression Regulation Genome Genome, Human Humans Liver - drug effects Liver - metabolism Mice Oligonucleotide Array Sequence Analysis Original Articles Software Transcription, Genetic |
| title | In Silico Drug Screen in Mouse Liver Identifies Candidate Calorie Restriction Mimetics |
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