Ligand-activated PPARδ inhibits UVB-induced senescence of human keratinocytes via PTEN-mediated inhibition of superoxide production

UV radiation-mediated photodamage to the skin has been implicated in premature aging and photoaging-related skin cancer and melanoma. Little is known about the cellular events that underlie premature senescence, or how to impede these events. In the present study we demonstrate that PPARδ (peroxisom...

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Veröffentlicht in:	Biochemical journal 2012-05, Vol.444 (1), p.27-38
Hauptverfasser:	Ham, Sun Ah, Hwang, Jung Seok, Yoo, Taesik, Lee, Hanna, Kang, Eun Sil, Park, Chankyu, Oh, Jae-Wook, Lee, Hoon Taek, Min, Gyesik, Kim, Jin-Hoi, Seo, Han Geuk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - metabolism Cells, Cultured Cellular Senescence Child Enzyme Activation Humans Keratinocytes - physiology Keratinocytes - radiation effects Ligands Mice Mice, Hairless Phosphatidylinositol 3-Kinases - physiology PPAR delta - agonists PPAR delta - physiology Protein Transport Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - biosynthesis PTEN Phosphohydrolase - physiology rac1 GTP-Binding Protein - metabolism Signal Transduction Skin - cytology Skin - metabolism Skin - radiation effects Superoxides - antagonists & inhibitors Superoxides - metabolism Thiazoles - pharmacology Ultraviolet Rays Up-Regulation
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