Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1

SphK (sphingosine kinase) is the major source of the bioactive lipid and GPCR (G-protein-coupled receptor) agonist S1P (sphingosine 1-phosphate). S1P promotes cell growth, survival and migration, and is a key regulator of lymphocyte trafficking. Inhibition of S1P signalling has been proposed as a st...

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Veröffentlicht in:	Biochemical journal 2012-05, Vol.444 (1), p.79-88
Hauptverfasser:	Schnute, Mark E, McReynolds, Matthew D, Kasten, Tom, Yates, Matthew, Jerome, Gina, Rains, John W, Hall, Troii, Chrencik, Jill, Kraus, Michelle, Cronin, Ciaran N, Saabye, Matthew, Highkin, Maureen K, Broadus, Richard, Ogawa, Shinji, Cukyne, Kristin, Zawadzke, Laura E, Peterkin, Vincent, Iyanar, Kaliapan, Scholten, Jeffrey A, Wendling, Jay, Fujiwara, Hideji, Nemirovskiy, Olga, Wittwer, Arthur J, Nagiec, Marek M
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Membrane Permeability Humans Lysophospholipids - blood Lysophospholipids - metabolism Phosphorylation Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors Pyrrolidines - chemical synthesis Pyrrolidines - metabolism Pyrrolidines - pharmacology Sphingosine - analogs & derivatives Sphingosine - blood Sphingosine - metabolism Substrate Specificity Sulfones - chemical synthesis Sulfones - metabolism Sulfones - pharmacology
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