Neonatal lymph node stromal cells drive myelodendritic lineage cells into a distinct population of CX3CR1+CD11b+F4/80+ regulatory macrophages in mice

Beyond providing a scaffold for immune cells, recent studies indicate that lymph node stromal cells provide potent regulatory capacities that affect the quality of adaptive immune responses. In this study, we provide evidence that neonatal lymph node stromal cells (nnLNSCs) consistently promote the...

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Veröffentlicht in:	Blood 2012-04, Vol.119 (17), p.3975-3986
Hauptverfasser:	Zhang, Xiangyue, Yu, Songfeng, Hoffmann, Katharina, Yu, Kai, Förster, Reinhold
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn B7-1 Antigen - metabolism Biological and medical sciences CD11b Antigen - metabolism Cell Lineage Cell Proliferation Cells, Cultured CX3C Chemokine Receptor 1 Dendritic Cells - cytology Dendritic Cells - immunology Dendritic Cells - metabolism Enzyme-Linked Immunosorbent Assay Flow Cytometry Hematologic and hematopoietic diseases Histocompatibility Antigens Class II - immunology Lymph Nodes - cytology Lymph Nodes - immunology Lymph Nodes - metabolism Macrophages - cytology Macrophages - immunology Macrophages - metabolism Medical sciences Mice Mice, Inbred C57BL Myeloid Cells - cytology Myeloid Cells - immunology Myeloid Cells - metabolism Nitric Oxide - metabolism Nitric Oxide Synthase Type II - metabolism Phenotype Receptors, Chemokine - metabolism Stromal Cells - cytology Stromal Cells - immunology Stromal Cells - metabolism T-Lymphocytes - immunology T-Lymphocytes - metabolism
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