Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state

Mitogen-activated protein kinase kinase 6 (MAP2K6) plays a crucial role in the p38 MAP kinase signal cascade that regulates various stress-induced responses and is associated with pathological conditions. The crystal structure of human non-phosphorylated MAP2K6 (npMAP2K6) complexed with an ATP analo...

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Veröffentlicht in:	Journal of biochemistry (Tokyo) 2012-05, Vol.151 (5), p.541-549
Hauptverfasser:	Matsumoto, Takashi, Kinoshita, Takayoshi, Matsuzaka, Hitomi, Nakai, Ryoko, Kirii, Yasuyuki, Yokota, Koichi, Tada, Toshiji
Format:	Artikel
Sprache:	eng
Schlagworte:	Crystallography, X-Ray Humans MAP Kinase Kinase 6 - antagonists & inhibitors MAP Kinase Kinase 6 - chemistry MAP Kinase Kinase 6 - metabolism Models, Molecular Protein Conformation Structure-Activity Relationship
Online-Zugang:	Volltext
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