Alteration of Y-box binding protein-1 expression modifies the response to endocrine therapy in estrogen receptor-positive breast cancer

Y-box binding protein-1 (YB-1) plays an important role in tumor progression and drug resistance. This study examined whether YB-1 is involved in the alteration of response to endocrine therapy in estrogen receptor (ER)-positive breast cancer cells. MCF7 cells that stably expressed YB-1 (MCF7-YB-1) a...

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Veröffentlicht in:	Breast cancer research and treatment 2012-05, Vol.133 (1), p.145-159
Hauptverfasser:	Ito, Tokiko, Kamijo, Shinobu, Izumi, Hiroto, Kohno, Kimitoshi, Amano, Jun, Ito, Ken-ichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Antineoplastic Agents, Hormonal - pharmacology Biological and medical sciences Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - pathology Cancer Cancer research Cancer therapies Cell Cycle - drug effects Cell Line, Tumor - drug effects Chemotherapy Chemotherapy, Adjuvant Development and progression Drug resistance Endocrine therapy Estradiol - analogs & derivatives Estradiol - pharmacology Estrogen Estrogen Receptor alpha - genetics Estrogen Receptor alpha - metabolism Estrogens Female Gene Expression Gene Expression Regulation, Neoplastic Genes, Reporter Gynecology. Andrology. Obstetrics Health aspects Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Luciferases, Renilla - biosynthesis Luciferases, Renilla - genetics Mammary gland diseases Medical sciences Medicine Medicine & Public Health Oncology Phenols Preclinical Study Protein binding Proteins Receptor Cross-Talk Response Elements Signal Transduction Tamoxifen Tamoxifen - pharmacology Tumors Y-Box-Binding Protein 1 - genetics Y-Box-Binding Protein 1 - metabolism
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