Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis
Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protect...
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| Veröffentlicht in: | Journal of natural products (Washington, D.C.) D.C.), 2012-04, Vol.75 (4), p.531-537 |
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| container_title | Journal of natural products (Washington, D.C.) |
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| creator | Qian, Erin Wei Ge, Daniel Tianfang Kong, Siu-Kai |
| description | Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study therefore has investigated the effects of 1 on oxidative stress-induced apoptosis in human erythrocytes (also known as eryptosis or erythroptosis). Compound 1 increased cell survival significantly and prevented human erythrocytes from undergoing eryptosis/erythroptosis mediated by H2O2, as confirmed by the decreased expression of phosphatidylserine on the cell surface and reduced leakage of calcein through the damaged membrane. Mechanistically, 1 was found to exert its protective effects through its antioxidative activity and the inhibition of caspase-3 activation and stress-induced intracellular Ca2+ rise in a dose-dependent manner. Compound 1 is a protective agent in human erythrocytes against oxidative stress and may be a good adaptogen to enhance the body’s resistance to stress and fatigue. |
| doi_str_mv | 10.1021/np200555s |
| format | Article |
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Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study therefore has investigated the effects of 1 on oxidative stress-induced apoptosis in human erythrocytes (also known as eryptosis or erythroptosis). Compound 1 increased cell survival significantly and prevented human erythrocytes from undergoing eryptosis/erythroptosis mediated by H2O2, as confirmed by the decreased expression of phosphatidylserine on the cell surface and reduced leakage of calcein through the damaged membrane. Mechanistically, 1 was found to exert its protective effects through its antioxidative activity and the inhibition of caspase-3 activation and stress-induced intracellular Ca2+ rise in a dose-dependent manner. Compound 1 is a protective agent in human erythrocytes against oxidative stress and may be a good adaptogen to enhance the body’s resistance to stress and fatigue.</description><identifier>ISSN: 0163-3864</identifier><identifier>EISSN: 1520-6025</identifier><identifier>DOI: 10.1021/np200555s</identifier><identifier>PMID: 22483064</identifier><language>eng</language><publisher>United States: American Chemical Society and American Society of Pharmacognosy</publisher><subject>Antioxidants - pharmacology ; Apoptosis - drug effects ; Calcium - analysis ; Dose-Response Relationship, Drug ; Erythrocytes - metabolism ; Glucosides - blood ; Glucosides - pharmacology ; Humans ; Hydrogen Peroxide - pharmacology ; Molecular Structure ; Oxidative Stress - drug effects ; Phenols - blood ; Phenols - pharmacology ; Rhodiola - chemistry</subject><ispartof>Journal of natural products (Washington, D.C.), 2012-04, Vol.75 (4), p.531-537</ispartof><rights>Copyright © 2012 American Chemical Society and American Society of Pharmacognosy</rights><rights>2012 American Chemical Society and American Society of Pharmacognosy</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a381t-1b4a8d5fceda797d8b6c71d57b3acfecb0a64c6ba54d1f1473b512555c5699b23</citedby><cites>FETCH-LOGICAL-a381t-1b4a8d5fceda797d8b6c71d57b3acfecb0a64c6ba54d1f1473b512555c5699b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/np200555s$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/np200555s$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,780,784,2765,27076,27924,27925,56738,56788</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22483064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qian, Erin Wei</creatorcontrib><creatorcontrib>Ge, Daniel Tianfang</creatorcontrib><creatorcontrib>Kong, Siu-Kai</creatorcontrib><title>Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis</title><title>Journal of natural products (Washington, D.C.)</title><addtitle>J. Nat. Prod</addtitle><description>Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study therefore has investigated the effects of 1 on oxidative stress-induced apoptosis in human erythrocytes (also known as eryptosis or erythroptosis). Compound 1 increased cell survival significantly and prevented human erythrocytes from undergoing eryptosis/erythroptosis mediated by H2O2, as confirmed by the decreased expression of phosphatidylserine on the cell surface and reduced leakage of calcein through the damaged membrane. Mechanistically, 1 was found to exert its protective effects through its antioxidative activity and the inhibition of caspase-3 activation and stress-induced intracellular Ca2+ rise in a dose-dependent manner. Compound 1 is a protective agent in human erythrocytes against oxidative stress and may be a good adaptogen to enhance the body’s resistance to stress and fatigue.</description><subject>Antioxidants - pharmacology</subject><subject>Apoptosis - drug effects</subject><subject>Calcium - analysis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Erythrocytes - metabolism</subject><subject>Glucosides - blood</subject><subject>Glucosides - pharmacology</subject><subject>Humans</subject><subject>Hydrogen Peroxide - pharmacology</subject><subject>Molecular Structure</subject><subject>Oxidative Stress - drug effects</subject><subject>Phenols - blood</subject><subject>Phenols - pharmacology</subject><subject>Rhodiola - chemistry</subject><issn>0163-3864</issn><issn>1520-6025</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkEtLw0AURgdRbK0u_AOSjaCL6Dwyk2RZSrWFgoXqOswrNSXJxJkJNP_eKa1dubqbcw98B4B7BF8QxOi17TCElFJ3AcaIYhgziOklGEPESEwylozAjXM7CCGBOb0GI4yTjECWjMFmw-tKWeMqpaO1NV5L76JF3_A2mtvBf1sjB69dxLe8ap2PFkOgt7qN1tqaffiKl63qpVbRtDOdDyJ3C65KXjt9d7oT8PU2_5wt4tXH-3I2XcWcZMjHSCQ8U7QMvzzNU5UJJlOkaCoIl6WWAnKWSCY4TRQqUZISQREOMyVleS4wmYCno7ez5qfXzhdN5aSua95q07sCwVCH4Iwe0OcjKsNUZ3VZdLZquB0CVBwaFueGgX04aXvRaHUm_6IF4PEIcOmKneltG1b-I_oF5HZ5gA</recordid><startdate>20120427</startdate><enddate>20120427</enddate><creator>Qian, Erin Wei</creator><creator>Ge, Daniel Tianfang</creator><creator>Kong, Siu-Kai</creator><general>American Chemical Society and American Society of Pharmacognosy</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120427</creationdate><title>Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis</title><author>Qian, Erin Wei ; Ge, Daniel Tianfang ; Kong, Siu-Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a381t-1b4a8d5fceda797d8b6c71d57b3acfecb0a64c6ba54d1f1473b512555c5699b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Antioxidants - pharmacology</topic><topic>Apoptosis - drug effects</topic><topic>Calcium - analysis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Erythrocytes - metabolism</topic><topic>Glucosides - blood</topic><topic>Glucosides - pharmacology</topic><topic>Humans</topic><topic>Hydrogen Peroxide - pharmacology</topic><topic>Molecular Structure</topic><topic>Oxidative Stress - drug effects</topic><topic>Phenols - blood</topic><topic>Phenols - pharmacology</topic><topic>Rhodiola - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qian, Erin Wei</creatorcontrib><creatorcontrib>Ge, Daniel Tianfang</creatorcontrib><creatorcontrib>Kong, Siu-Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of natural products (Washington, D.C.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qian, Erin Wei</au><au>Ge, Daniel Tianfang</au><au>Kong, Siu-Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis</atitle><jtitle>Journal of natural products (Washington, D.C.)</jtitle><addtitle>J. Nat. Prod</addtitle><date>2012-04-27</date><risdate>2012</risdate><volume>75</volume><issue>4</issue><spage>531</spage><epage>537</epage><pages>531-537</pages><issn>0163-3864</issn><eissn>1520-6025</eissn><abstract>Rhodiola rosea is a commonly used folk medicine for the treatment of high altitude sickness, mountain malhypoxia, and anoxia. Its active ingredient, salidroside [2-(4-hydroxyphenyl)ethyl β-d-glucopyranoside (1)], has been reported to have a broad spectrum of biological effects. However, the protective role of 1 in human erythrocytes remains unclear. This study therefore has investigated the effects of 1 on oxidative stress-induced apoptosis in human erythrocytes (also known as eryptosis or erythroptosis). Compound 1 increased cell survival significantly and prevented human erythrocytes from undergoing eryptosis/erythroptosis mediated by H2O2, as confirmed by the decreased expression of phosphatidylserine on the cell surface and reduced leakage of calcein through the damaged membrane. Mechanistically, 1 was found to exert its protective effects through its antioxidative activity and the inhibition of caspase-3 activation and stress-induced intracellular Ca2+ rise in a dose-dependent manner. Compound 1 is a protective agent in human erythrocytes against oxidative stress and may be a good adaptogen to enhance the body’s resistance to stress and fatigue.</abstract><cop>United States</cop><pub>American Chemical Society and American Society of Pharmacognosy</pub><pmid>22483064</pmid><doi>10.1021/np200555s</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0163-3864 |
| ispartof | Journal of natural products (Washington, D.C.), 2012-04, Vol.75 (4), p.531-537 |
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| source | MEDLINE; ACS Publications |
| subjects | Antioxidants - pharmacology Apoptosis - drug effects Calcium - analysis Dose-Response Relationship, Drug Erythrocytes - metabolism Glucosides - blood Glucosides - pharmacology Humans Hydrogen Peroxide - pharmacology Molecular Structure Oxidative Stress - drug effects Phenols - blood Phenols - pharmacology Rhodiola - chemistry |
| title | Salidroside Protects Human Erythrocytes against Hydrogen Peroxide-Induced Apoptosis |
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