Effects of Aging on Angiogenesis

Aging is a dominant risk factor for most forms of cardiovascular disease. Impaired angiogenesis and endothelial dysfunction likely contribute to the increased prevalence of both cardiovascular diseases and their adverse sequelae in the elderly. Angiogenesis is both an essential adaptive response to...

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Veröffentlicht in:	Circulation research 2012-04, Vol.110 (9), p.1252-1264
Hauptverfasser:	Lähteenvuo, Johanna, Rosenzweig, Anthony
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging - metabolism Angiogenic Proteins - metabolism Animals Biological and medical sciences Cardiovascular Diseases - etiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - physiopathology Cardiovascular Diseases - therapy Cellular Senescence Cyclin-Dependent Kinase Inhibitor Proteins - metabolism Fundamental and applied biological sciences. Psychology Humans Neovascularization, Physiologic Nitric Oxide - metabolism Oxidative Stress Risk Factors Signal Transduction Vertebrates: cardiovascular system
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