The Predictive Effect of Cadherin-17 on Lymph Node Micrometastasis in pN0 Gastric Cancer
Background Previous studies identified cadherin-17 (CDH17) as one of the most upregulated genes in node-positive gastric cancer. However, the prognostic significance of CDH17 in pN0 gastric cancer and its association with lymph node micrometastasis (LNMM) have not been investigated. Methods Clinicop...
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| Veröffentlicht in: | Annals of surgical oncology 2012-05, Vol.19 (5), p.1529-1534 |
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| container_title | Annals of surgical oncology |
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| creator | Wang, Jin Yu, Jian-Chun Kang, Wei-Ming Wang, Wen-Ze Liu, Yu-Qin Gu, Pei |
| description | Background
Previous studies identified cadherin-17 (CDH17) as one of the most upregulated genes in node-positive gastric cancer. However, the prognostic significance of CDH17 in pN0 gastric cancer and its association with lymph node micrometastasis (LNMM) have not been investigated.
Methods
Clinicopathologic features of 191 patients with node-negative gastric cancer were studied retrospectively. All dissected lymph nodes were immunostained by cytokeratin to detect micrometastasis. CDH17 and lymphatic invasion (LVI) in primary carcinoma were evaluated by immunostaining of monoclonal CDH17 and D2-40 antibody. Correlation of CDH17 with clinicopathologic characteristics was subsequently assessed. Risk factors of LNMM were analyzed by univariate and multivariate logistic regression. Cox’s proportional hazard model was applied to investigate independent prognostic factors of pN0 gastric cancer. Overall survival rates of patients with positive and negative CDH17 were compared, stratifying by pT stage, Lauren grade, and LNMM status.
Results
CDH17 was observed in 126 patients (66.0%). Positive expression of CDH17 was significantly associated with the age, tumor size, pT, Lauren grade, LVI, and LNMM, and identified as one of the independent risk factors of LNMM. Negative predictors of pN0 gastric cancer included pT, Lauren grade, LNMM, and CDH17. Furthermore, in tumors of pT2-3, intestinal histotype, and negative-LNMM, the survival rate of patients with CDH17 was significantly lower than that of patients without CDH17.
Conclusions
CDH17 was positively associated with larger tumor size, deeper invasion, diffuse/mixed histotype, LVI, and LNMM, predicting a poor prognosis in pN0 gastric cancer. Additionally, CDH17 may also serve as a potential indicator of LNMM. |
| doi_str_mv | 10.1245/s10434-011-2115-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1009539638</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1009539638</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-e6123da07b77bfb84ec575849d8525445cc607007f975de889f9e16d05e10f913</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMofv8ALxLw4qWaaZImPcriF6yrhxW8lW46cSPbdk26gv_ekVURQQgkM3neN5mXsSMQZ5ArfZ5AKKkyAZDlADqTG2wXNHVUYWGTzqKwWZkXeoftpfQiBBgp9DbbyXMhqF_usqfpHPlDxCa4Ibwhv_Qe3cB7z0d1M8cYugwM7zs-fm-Xcz7pG-R3wcW-xaFOtELioePLieDXVMfgSNg5jAdsy9eLhIdf-z57vLqcjm6y8f317ehinDkl7ZBhAblsamFmxsz8zCp02mirysbqXCulnSuEEcL40ugGrS19iVA0QiMIX4LcZ6dr32XsX1eYhqoNyeFiUXfYr1IFNKmWZSEtoSd_0Jd-FTv6HVEgVUGZGqJgTdGQKUX01TKGto7vBFWfsVfr2CuKvfqMvZKkOf5yXs1abH4U3zkTkK-BRFfdM8bfT__n-gFP9onY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1013462457</pqid></control><display><type>article</type><title>The Predictive Effect of Cadherin-17 on Lymph Node Micrometastasis in pN0 Gastric Cancer</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><creator>Wang, Jin ; Yu, Jian-Chun ; Kang, Wei-Ming ; Wang, Wen-Ze ; Liu, Yu-Qin ; Gu, Pei</creator><creatorcontrib>Wang, Jin ; Yu, Jian-Chun ; Kang, Wei-Ming ; Wang, Wen-Ze ; Liu, Yu-Qin ; Gu, Pei</creatorcontrib><description>Background
Previous studies identified cadherin-17 (CDH17) as one of the most upregulated genes in node-positive gastric cancer. However, the prognostic significance of CDH17 in pN0 gastric cancer and its association with lymph node micrometastasis (LNMM) have not been investigated.
Methods
Clinicopathologic features of 191 patients with node-negative gastric cancer were studied retrospectively. All dissected lymph nodes were immunostained by cytokeratin to detect micrometastasis. CDH17 and lymphatic invasion (LVI) in primary carcinoma were evaluated by immunostaining of monoclonal CDH17 and D2-40 antibody. Correlation of CDH17 with clinicopathologic characteristics was subsequently assessed. Risk factors of LNMM were analyzed by univariate and multivariate logistic regression. Cox’s proportional hazard model was applied to investigate independent prognostic factors of pN0 gastric cancer. Overall survival rates of patients with positive and negative CDH17 were compared, stratifying by pT stage, Lauren grade, and LNMM status.
Results
CDH17 was observed in 126 patients (66.0%). Positive expression of CDH17 was significantly associated with the age, tumor size, pT, Lauren grade, LVI, and LNMM, and identified as one of the independent risk factors of LNMM. Negative predictors of pN0 gastric cancer included pT, Lauren grade, LNMM, and CDH17. Furthermore, in tumors of pT2-3, intestinal histotype, and negative-LNMM, the survival rate of patients with CDH17 was significantly lower than that of patients without CDH17.
Conclusions
CDH17 was positively associated with larger tumor size, deeper invasion, diffuse/mixed histotype, LVI, and LNMM, predicting a poor prognosis in pN0 gastric cancer. Additionally, CDH17 may also serve as a potential indicator of LNMM.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-011-2115-3</identifier><identifier>PMID: 22009269</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biomarkers, Tumor - analysis ; Cadherins - analysis ; Carcinoma - chemistry ; Carcinoma - mortality ; Carcinoma - pathology ; Carcinoma - secondary ; Female ; Follow-Up Studies ; Gastrointestinal Oncology ; Humans ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Grading ; Neoplasm Invasiveness - pathology ; Neoplasm Micrometastasis ; Neoplasm Staging ; Oncology ; Predictive Value of Tests ; Prognosis ; Retrospective Studies ; Stomach Neoplasms - chemistry ; Stomach Neoplasms - mortality ; Stomach Neoplasms - pathology ; Surgery ; Surgical Oncology ; Survival Rate</subject><ispartof>Annals of surgical oncology, 2012-05, Vol.19 (5), p.1529-1534</ispartof><rights>Society of Surgical Oncology 2011</rights><rights>Society of Surgical Oncology 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-e6123da07b77bfb84ec575849d8525445cc607007f975de889f9e16d05e10f913</citedby><cites>FETCH-LOGICAL-c438t-e6123da07b77bfb84ec575849d8525445cc607007f975de889f9e16d05e10f913</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-011-2115-3$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-011-2115-3$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27928,27929,41492,42561,51323</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22009269$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Yu, Jian-Chun</creatorcontrib><creatorcontrib>Kang, Wei-Ming</creatorcontrib><creatorcontrib>Wang, Wen-Ze</creatorcontrib><creatorcontrib>Liu, Yu-Qin</creatorcontrib><creatorcontrib>Gu, Pei</creatorcontrib><title>The Predictive Effect of Cadherin-17 on Lymph Node Micrometastasis in pN0 Gastric Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
Previous studies identified cadherin-17 (CDH17) as one of the most upregulated genes in node-positive gastric cancer. However, the prognostic significance of CDH17 in pN0 gastric cancer and its association with lymph node micrometastasis (LNMM) have not been investigated.
Methods
Clinicopathologic features of 191 patients with node-negative gastric cancer were studied retrospectively. All dissected lymph nodes were immunostained by cytokeratin to detect micrometastasis. CDH17 and lymphatic invasion (LVI) in primary carcinoma were evaluated by immunostaining of monoclonal CDH17 and D2-40 antibody. Correlation of CDH17 with clinicopathologic characteristics was subsequently assessed. Risk factors of LNMM were analyzed by univariate and multivariate logistic regression. Cox’s proportional hazard model was applied to investigate independent prognostic factors of pN0 gastric cancer. Overall survival rates of patients with positive and negative CDH17 were compared, stratifying by pT stage, Lauren grade, and LNMM status.
Results
CDH17 was observed in 126 patients (66.0%). Positive expression of CDH17 was significantly associated with the age, tumor size, pT, Lauren grade, LVI, and LNMM, and identified as one of the independent risk factors of LNMM. Negative predictors of pN0 gastric cancer included pT, Lauren grade, LNMM, and CDH17. Furthermore, in tumors of pT2-3, intestinal histotype, and negative-LNMM, the survival rate of patients with CDH17 was significantly lower than that of patients without CDH17.
Conclusions
CDH17 was positively associated with larger tumor size, deeper invasion, diffuse/mixed histotype, LVI, and LNMM, predicting a poor prognosis in pN0 gastric cancer. Additionally, CDH17 may also serve as a potential indicator of LNMM.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Cadherins - analysis</subject><subject>Carcinoma - chemistry</subject><subject>Carcinoma - mortality</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - secondary</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gastrointestinal Oncology</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Grading</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Micrometastasis</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Stomach Neoplasms - chemistry</subject><subject>Stomach Neoplasms - mortality</subject><subject>Stomach Neoplasms - pathology</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LxDAQhoMofv8ALxLw4qWaaZImPcriF6yrhxW8lW46cSPbdk26gv_ekVURQQgkM3neN5mXsSMQZ5ArfZ5AKKkyAZDlADqTG2wXNHVUYWGTzqKwWZkXeoftpfQiBBgp9DbbyXMhqF_usqfpHPlDxCa4Ibwhv_Qe3cB7z0d1M8cYugwM7zs-fm-Xcz7pG-R3wcW-xaFOtELioePLieDXVMfgSNg5jAdsy9eLhIdf-z57vLqcjm6y8f317ehinDkl7ZBhAblsamFmxsz8zCp02mirysbqXCulnSuEEcL40ugGrS19iVA0QiMIX4LcZ6dr32XsX1eYhqoNyeFiUXfYr1IFNKmWZSEtoSd_0Jd-FTv6HVEgVUGZGqJgTdGQKUX01TKGto7vBFWfsVfr2CuKvfqMvZKkOf5yXs1abH4U3zkTkK-BRFfdM8bfT__n-gFP9onY</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Wang, Jin</creator><creator>Yu, Jian-Chun</creator><creator>Kang, Wei-Ming</creator><creator>Wang, Wen-Ze</creator><creator>Liu, Yu-Qin</creator><creator>Gu, Pei</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>The Predictive Effect of Cadherin-17 on Lymph Node Micrometastasis in pN0 Gastric Cancer</title><author>Wang, Jin ; Yu, Jian-Chun ; Kang, Wei-Ming ; Wang, Wen-Ze ; Liu, Yu-Qin ; Gu, Pei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-e6123da07b77bfb84ec575849d8525445cc607007f975de889f9e16d05e10f913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Cadherins - analysis</topic><topic>Carcinoma - chemistry</topic><topic>Carcinoma - mortality</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - secondary</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gastrointestinal Oncology</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Grading</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Micrometastasis</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Stomach Neoplasms - chemistry</topic><topic>Stomach Neoplasms - mortality</topic><topic>Stomach Neoplasms - pathology</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Jin</creatorcontrib><creatorcontrib>Yu, Jian-Chun</creatorcontrib><creatorcontrib>Kang, Wei-Ming</creatorcontrib><creatorcontrib>Wang, Wen-Ze</creatorcontrib><creatorcontrib>Liu, Yu-Qin</creatorcontrib><creatorcontrib>Gu, Pei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Jin</au><au>Yu, Jian-Chun</au><au>Kang, Wei-Ming</au><au>Wang, Wen-Ze</au><au>Liu, Yu-Qin</au><au>Gu, Pei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Predictive Effect of Cadherin-17 on Lymph Node Micrometastasis in pN0 Gastric Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>19</volume><issue>5</issue><spage>1529</spage><epage>1534</epage><pages>1529-1534</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Background
Previous studies identified cadherin-17 (CDH17) as one of the most upregulated genes in node-positive gastric cancer. However, the prognostic significance of CDH17 in pN0 gastric cancer and its association with lymph node micrometastasis (LNMM) have not been investigated.
Methods
Clinicopathologic features of 191 patients with node-negative gastric cancer were studied retrospectively. All dissected lymph nodes were immunostained by cytokeratin to detect micrometastasis. CDH17 and lymphatic invasion (LVI) in primary carcinoma were evaluated by immunostaining of monoclonal CDH17 and D2-40 antibody. Correlation of CDH17 with clinicopathologic characteristics was subsequently assessed. Risk factors of LNMM were analyzed by univariate and multivariate logistic regression. Cox’s proportional hazard model was applied to investigate independent prognostic factors of pN0 gastric cancer. Overall survival rates of patients with positive and negative CDH17 were compared, stratifying by pT stage, Lauren grade, and LNMM status.
Results
CDH17 was observed in 126 patients (66.0%). Positive expression of CDH17 was significantly associated with the age, tumor size, pT, Lauren grade, LVI, and LNMM, and identified as one of the independent risk factors of LNMM. Negative predictors of pN0 gastric cancer included pT, Lauren grade, LNMM, and CDH17. Furthermore, in tumors of pT2-3, intestinal histotype, and negative-LNMM, the survival rate of patients with CDH17 was significantly lower than that of patients without CDH17.
Conclusions
CDH17 was positively associated with larger tumor size, deeper invasion, diffuse/mixed histotype, LVI, and LNMM, predicting a poor prognosis in pN0 gastric cancer. Additionally, CDH17 may also serve as a potential indicator of LNMM.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>22009269</pmid><doi>10.1245/s10434-011-2115-3</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2012-05, Vol.19 (5), p.1529-1534 |
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| subjects | Adult Aged Aged, 80 and over Biomarkers, Tumor - analysis Cadherins - analysis Carcinoma - chemistry Carcinoma - mortality Carcinoma - pathology Carcinoma - secondary Female Follow-Up Studies Gastrointestinal Oncology Humans Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Neoplasm Grading Neoplasm Invasiveness - pathology Neoplasm Micrometastasis Neoplasm Staging Oncology Predictive Value of Tests Prognosis Retrospective Studies Stomach Neoplasms - chemistry Stomach Neoplasms - mortality Stomach Neoplasms - pathology Surgery Surgical Oncology Survival Rate |
| title | The Predictive Effect of Cadherin-17 on Lymph Node Micrometastasis in pN0 Gastric Cancer |
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