The Effect of Definity on Systemic and Pulmonary Hemodynamics in Patients
Background The purpose of this study was to evaluate the pulmonary and systemic hemodynamic effects of Definity in patients with normal as well as those with elevated pulmonary artery pressure at baseline. Secondary objectives of the study were to evaluate safety and determine whether any potential...
Gespeichert in:
Veröffentlicht in: | Journal of the American Society of Echocardiography 2012-05, Vol.25 (5), p.584-588 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 588 |
---|---|
container_issue | 5 |
container_start_page | 584 |
container_title | Journal of the American Society of Echocardiography |
container_volume | 25 |
creator | Wei, Kevin, MD Main, Michael L., MD Lang, Roberto M., MD Klein, Allan, MD Angeli, Stephen, MD Panetta, Carmelo, MD Mikati, Issam, MD Lee, L. Veronica, MD Bernstein, Jonathan A., MD Ahmad, Masood, MD |
description | Background The purpose of this study was to evaluate the pulmonary and systemic hemodynamic effects of Definity in patients with normal as well as those with elevated pulmonary artery pressure at baseline. Secondary objectives of the study were to evaluate safety and determine whether any potential immunologic reactions develop after Definity administration. Methods Patients with normal and elevated pulmonary artery systolic pressure undergoing right-heart catheterization received Definity (10 μL/kg) as a slow bolus over 30 to 60 sec. Multiple sequential measurements of right atrial pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, mean pulmonary artery pressure, cardiac output, and pulmonary capillary wedge pressure were made before and after Definity administration. Vital signs, electrocardiograms, and blood samples were taken at multiple time points. Patients were followed for the development of adverse events. Results A total of 32 patients (16 with elevated pulmonary artery systolic pressure > 35 mm Hg) were enrolled. No significant changes in any pulmonary or systemic hemodynamic parameters, vital sign values, electrocardiographic data, or laboratory variables were found for data obtained before versus after receipt of Definity. Conclusions The administration of Definity at the approved dosage does not change pulmonary or systemic hemodynamics in control patients or those with mild to moderate pulmonary hypertension. No significant changes were noted in a wide array of clinical and laboratory safety assessments after patients were exposed to Definity. |
doi_str_mv | 10.1016/j.echo.2012.01.019 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1009531119</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0894731712000946</els_id><sourcerecordid>1009531119</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-503356fb1e738697ec88be99eb8f249cac96c50f5535e5aaf80ec9d6de8601cd3</originalsourceid><addsrcrecordid>eNp9kUFr3DAQhUVpabZp_0APRcdevJ2xVrIFpVDSNAkEGkh6Flp5RLS1pdSyA_73ldm0hxwKA3OY9x7M9xh7j7BFQPXpsCV3n7Y1YL0FLKNfsA2CbirVaPmSbaDVu6oR2JywNzkfAEC2AK_ZSV0LJRvQG3Z1d0_83HtyE0-efyMfYpgWniK_XfJEQ3Dcxo7fzP2Qoh0XfklD6pZoyyXzEPmNnQLFKb9lr7ztM7172qfs5_fzu7PL6vrHxdXZ1-vK7RCnSoIQUvk9UiNapRtybbsnrWnf-nqnnXVaOQleSiFJWutbIKc71VGrAF0nTtnHY-7DmH7PlCczhOyo722kNGeDAFoKRNRFWh-lbkw5j-TNwxiG8kQRmRWhOZgVoVkRGsAyq-nDU_68H6j7Z_nLrAg-HwVUvnwMNJrsCgFHXRgLRtOl8P_8L8_sri_Mne1_0UL5kOYxFn4GTS4ec7uWuHaIdelP75T4A7fylps</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1009531119</pqid></control><display><type>article</type><title>The Effect of Definity on Systemic and Pulmonary Hemodynamics in Patients</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Wei, Kevin, MD ; Main, Michael L., MD ; Lang, Roberto M., MD ; Klein, Allan, MD ; Angeli, Stephen, MD ; Panetta, Carmelo, MD ; Mikati, Issam, MD ; Lee, L. Veronica, MD ; Bernstein, Jonathan A., MD ; Ahmad, Masood, MD</creator><creatorcontrib>Wei, Kevin, MD ; Main, Michael L., MD ; Lang, Roberto M., MD ; Klein, Allan, MD ; Angeli, Stephen, MD ; Panetta, Carmelo, MD ; Mikati, Issam, MD ; Lee, L. Veronica, MD ; Bernstein, Jonathan A., MD ; Ahmad, Masood, MD</creatorcontrib><description>Background The purpose of this study was to evaluate the pulmonary and systemic hemodynamic effects of Definity in patients with normal as well as those with elevated pulmonary artery pressure at baseline. Secondary objectives of the study were to evaluate safety and determine whether any potential immunologic reactions develop after Definity administration. Methods Patients with normal and elevated pulmonary artery systolic pressure undergoing right-heart catheterization received Definity (10 μL/kg) as a slow bolus over 30 to 60 sec. Multiple sequential measurements of right atrial pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, mean pulmonary artery pressure, cardiac output, and pulmonary capillary wedge pressure were made before and after Definity administration. Vital signs, electrocardiograms, and blood samples were taken at multiple time points. Patients were followed for the development of adverse events. Results A total of 32 patients (16 with elevated pulmonary artery systolic pressure > 35 mm Hg) were enrolled. No significant changes in any pulmonary or systemic hemodynamic parameters, vital sign values, electrocardiographic data, or laboratory variables were found for data obtained before versus after receipt of Definity. Conclusions The administration of Definity at the approved dosage does not change pulmonary or systemic hemodynamics in control patients or those with mild to moderate pulmonary hypertension. No significant changes were noted in a wide array of clinical and laboratory safety assessments after patients were exposed to Definity.</description><identifier>ISSN: 0894-7317</identifier><identifier>EISSN: 1097-6795</identifier><identifier>DOI: 10.1016/j.echo.2012.01.019</identifier><identifier>PMID: 22365709</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cardiac Catheterization - methods ; Cardiovascular ; Contrast echocardiography ; Contrast Media - adverse effects ; Dose-Response Relationship, Drug ; Drug Administration Schedule ; Drug Hypersensitivity - diagnosis ; Drug Hypersensitivity - epidemiology ; Echocardiography - methods ; Female ; Fluorocarbons - adverse effects ; Fluorocarbons - pharmacology ; Follow-Up Studies ; Hemodynamics ; Hemodynamics - drug effects ; Humans ; Hypertension, Pulmonary - diagnosis ; Hypertension, Pulmonary - diagnostic imaging ; Image Enhancement - methods ; Male ; Middle Aged ; Monitoring, Physiologic - methods ; Prospective Studies ; Pulmonary artery pressure ; Pulmonary Wedge Pressure - drug effects ; Risk Assessment ; Safety ; Safety Management ; Time Factors</subject><ispartof>Journal of the American Society of Echocardiography, 2012-05, Vol.25 (5), p.584-588</ispartof><rights>American Society of Echocardiography</rights><rights>2012 American Society of Echocardiography</rights><rights>Copyright © 2012 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-503356fb1e738697ec88be99eb8f249cac96c50f5535e5aaf80ec9d6de8601cd3</citedby><cites>FETCH-LOGICAL-c411t-503356fb1e738697ec88be99eb8f249cac96c50f5535e5aaf80ec9d6de8601cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.echo.2012.01.019$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22365709$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wei, Kevin, MD</creatorcontrib><creatorcontrib>Main, Michael L., MD</creatorcontrib><creatorcontrib>Lang, Roberto M., MD</creatorcontrib><creatorcontrib>Klein, Allan, MD</creatorcontrib><creatorcontrib>Angeli, Stephen, MD</creatorcontrib><creatorcontrib>Panetta, Carmelo, MD</creatorcontrib><creatorcontrib>Mikati, Issam, MD</creatorcontrib><creatorcontrib>Lee, L. Veronica, MD</creatorcontrib><creatorcontrib>Bernstein, Jonathan A., MD</creatorcontrib><creatorcontrib>Ahmad, Masood, MD</creatorcontrib><title>The Effect of Definity on Systemic and Pulmonary Hemodynamics in Patients</title><title>Journal of the American Society of Echocardiography</title><addtitle>J Am Soc Echocardiogr</addtitle><description>Background The purpose of this study was to evaluate the pulmonary and systemic hemodynamic effects of Definity in patients with normal as well as those with elevated pulmonary artery pressure at baseline. Secondary objectives of the study were to evaluate safety and determine whether any potential immunologic reactions develop after Definity administration. Methods Patients with normal and elevated pulmonary artery systolic pressure undergoing right-heart catheterization received Definity (10 μL/kg) as a slow bolus over 30 to 60 sec. Multiple sequential measurements of right atrial pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, mean pulmonary artery pressure, cardiac output, and pulmonary capillary wedge pressure were made before and after Definity administration. Vital signs, electrocardiograms, and blood samples were taken at multiple time points. Patients were followed for the development of adverse events. Results A total of 32 patients (16 with elevated pulmonary artery systolic pressure > 35 mm Hg) were enrolled. No significant changes in any pulmonary or systemic hemodynamic parameters, vital sign values, electrocardiographic data, or laboratory variables were found for data obtained before versus after receipt of Definity. Conclusions The administration of Definity at the approved dosage does not change pulmonary or systemic hemodynamics in control patients or those with mild to moderate pulmonary hypertension. No significant changes were noted in a wide array of clinical and laboratory safety assessments after patients were exposed to Definity.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cardiac Catheterization - methods</subject><subject>Cardiovascular</subject><subject>Contrast echocardiography</subject><subject>Contrast Media - adverse effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Administration Schedule</subject><subject>Drug Hypersensitivity - diagnosis</subject><subject>Drug Hypersensitivity - epidemiology</subject><subject>Echocardiography - methods</subject><subject>Female</subject><subject>Fluorocarbons - adverse effects</subject><subject>Fluorocarbons - pharmacology</subject><subject>Follow-Up Studies</subject><subject>Hemodynamics</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Hypertension, Pulmonary - diagnosis</subject><subject>Hypertension, Pulmonary - diagnostic imaging</subject><subject>Image Enhancement - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Monitoring, Physiologic - methods</subject><subject>Prospective Studies</subject><subject>Pulmonary artery pressure</subject><subject>Pulmonary Wedge Pressure - drug effects</subject><subject>Risk Assessment</subject><subject>Safety</subject><subject>Safety Management</subject><subject>Time Factors</subject><issn>0894-7317</issn><issn>1097-6795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUFr3DAQhUVpabZp_0APRcdevJ2xVrIFpVDSNAkEGkh6Flp5RLS1pdSyA_73ldm0hxwKA3OY9x7M9xh7j7BFQPXpsCV3n7Y1YL0FLKNfsA2CbirVaPmSbaDVu6oR2JywNzkfAEC2AK_ZSV0LJRvQG3Z1d0_83HtyE0-efyMfYpgWniK_XfJEQ3Dcxo7fzP2Qoh0XfklD6pZoyyXzEPmNnQLFKb9lr7ztM7172qfs5_fzu7PL6vrHxdXZ1-vK7RCnSoIQUvk9UiNapRtybbsnrWnf-nqnnXVaOQleSiFJWutbIKc71VGrAF0nTtnHY-7DmH7PlCczhOyo722kNGeDAFoKRNRFWh-lbkw5j-TNwxiG8kQRmRWhOZgVoVkRGsAyq-nDU_68H6j7Z_nLrAg-HwVUvnwMNJrsCgFHXRgLRtOl8P_8L8_sri_Mne1_0UL5kOYxFn4GTS4ec7uWuHaIdelP75T4A7fylps</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Wei, Kevin, MD</creator><creator>Main, Michael L., MD</creator><creator>Lang, Roberto M., MD</creator><creator>Klein, Allan, MD</creator><creator>Angeli, Stephen, MD</creator><creator>Panetta, Carmelo, MD</creator><creator>Mikati, Issam, MD</creator><creator>Lee, L. Veronica, MD</creator><creator>Bernstein, Jonathan A., MD</creator><creator>Ahmad, Masood, MD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>The Effect of Definity on Systemic and Pulmonary Hemodynamics in Patients</title><author>Wei, Kevin, MD ; Main, Michael L., MD ; Lang, Roberto M., MD ; Klein, Allan, MD ; Angeli, Stephen, MD ; Panetta, Carmelo, MD ; Mikati, Issam, MD ; Lee, L. Veronica, MD ; Bernstein, Jonathan A., MD ; Ahmad, Masood, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-503356fb1e738697ec88be99eb8f249cac96c50f5535e5aaf80ec9d6de8601cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cardiac Catheterization - methods</topic><topic>Cardiovascular</topic><topic>Contrast echocardiography</topic><topic>Contrast Media - adverse effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Administration Schedule</topic><topic>Drug Hypersensitivity - diagnosis</topic><topic>Drug Hypersensitivity - epidemiology</topic><topic>Echocardiography - methods</topic><topic>Female</topic><topic>Fluorocarbons - adverse effects</topic><topic>Fluorocarbons - pharmacology</topic><topic>Follow-Up Studies</topic><topic>Hemodynamics</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Hypertension, Pulmonary - diagnosis</topic><topic>Hypertension, Pulmonary - diagnostic imaging</topic><topic>Image Enhancement - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Monitoring, Physiologic - methods</topic><topic>Prospective Studies</topic><topic>Pulmonary artery pressure</topic><topic>Pulmonary Wedge Pressure - drug effects</topic><topic>Risk Assessment</topic><topic>Safety</topic><topic>Safety Management</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wei, Kevin, MD</creatorcontrib><creatorcontrib>Main, Michael L., MD</creatorcontrib><creatorcontrib>Lang, Roberto M., MD</creatorcontrib><creatorcontrib>Klein, Allan, MD</creatorcontrib><creatorcontrib>Angeli, Stephen, MD</creatorcontrib><creatorcontrib>Panetta, Carmelo, MD</creatorcontrib><creatorcontrib>Mikati, Issam, MD</creatorcontrib><creatorcontrib>Lee, L. Veronica, MD</creatorcontrib><creatorcontrib>Bernstein, Jonathan A., MD</creatorcontrib><creatorcontrib>Ahmad, Masood, MD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Society of Echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wei, Kevin, MD</au><au>Main, Michael L., MD</au><au>Lang, Roberto M., MD</au><au>Klein, Allan, MD</au><au>Angeli, Stephen, MD</au><au>Panetta, Carmelo, MD</au><au>Mikati, Issam, MD</au><au>Lee, L. Veronica, MD</au><au>Bernstein, Jonathan A., MD</au><au>Ahmad, Masood, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Definity on Systemic and Pulmonary Hemodynamics in Patients</atitle><jtitle>Journal of the American Society of Echocardiography</jtitle><addtitle>J Am Soc Echocardiogr</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>25</volume><issue>5</issue><spage>584</spage><epage>588</epage><pages>584-588</pages><issn>0894-7317</issn><eissn>1097-6795</eissn><abstract>Background The purpose of this study was to evaluate the pulmonary and systemic hemodynamic effects of Definity in patients with normal as well as those with elevated pulmonary artery pressure at baseline. Secondary objectives of the study were to evaluate safety and determine whether any potential immunologic reactions develop after Definity administration. Methods Patients with normal and elevated pulmonary artery systolic pressure undergoing right-heart catheterization received Definity (10 μL/kg) as a slow bolus over 30 to 60 sec. Multiple sequential measurements of right atrial pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, mean pulmonary artery pressure, cardiac output, and pulmonary capillary wedge pressure were made before and after Definity administration. Vital signs, electrocardiograms, and blood samples were taken at multiple time points. Patients were followed for the development of adverse events. Results A total of 32 patients (16 with elevated pulmonary artery systolic pressure > 35 mm Hg) were enrolled. No significant changes in any pulmonary or systemic hemodynamic parameters, vital sign values, electrocardiographic data, or laboratory variables were found for data obtained before versus after receipt of Definity. Conclusions The administration of Definity at the approved dosage does not change pulmonary or systemic hemodynamics in control patients or those with mild to moderate pulmonary hypertension. No significant changes were noted in a wide array of clinical and laboratory safety assessments after patients were exposed to Definity.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>22365709</pmid><doi>10.1016/j.echo.2012.01.019</doi><tpages>5</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0894-7317 |
ispartof | Journal of the American Society of Echocardiography, 2012-05, Vol.25 (5), p.584-588 |
issn | 0894-7317 1097-6795 |
language | eng |
recordid | cdi_proquest_miscellaneous_1009531119 |
source | MEDLINE; Elsevier ScienceDirect Journals |
subjects | Adult Aged Aged, 80 and over Cardiac Catheterization - methods Cardiovascular Contrast echocardiography Contrast Media - adverse effects Dose-Response Relationship, Drug Drug Administration Schedule Drug Hypersensitivity - diagnosis Drug Hypersensitivity - epidemiology Echocardiography - methods Female Fluorocarbons - adverse effects Fluorocarbons - pharmacology Follow-Up Studies Hemodynamics Hemodynamics - drug effects Humans Hypertension, Pulmonary - diagnosis Hypertension, Pulmonary - diagnostic imaging Image Enhancement - methods Male Middle Aged Monitoring, Physiologic - methods Prospective Studies Pulmonary artery pressure Pulmonary Wedge Pressure - drug effects Risk Assessment Safety Safety Management Time Factors |
title | The Effect of Definity on Systemic and Pulmonary Hemodynamics in Patients |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T20%3A03%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effect%20of%20Definity%20on%20Systemic%20and%20Pulmonary%20Hemodynamics%20in%20Patients&rft.jtitle=Journal%20of%20the%20American%20Society%20of%20Echocardiography&rft.au=Wei,%20Kevin,%20MD&rft.date=2012-05-01&rft.volume=25&rft.issue=5&rft.spage=584&rft.epage=588&rft.pages=584-588&rft.issn=0894-7317&rft.eissn=1097-6795&rft_id=info:doi/10.1016/j.echo.2012.01.019&rft_dat=%3Cproquest_cross%3E1009531119%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1009531119&rft_id=info:pmid/22365709&rft_els_id=1_s2_0_S0894731712000946&rfr_iscdi=true |