Right Ventricular Systolic Strain Is Altered in Children with Sickle Cell Disease
Background Several adult studies have shown that sickle cell disease is associated with cardiac abnormalities and premature death. The aim of this study was to use speckle-tracking strain, a relatively load independent parameter, to evaluate systolic left ventricular (LV) and right ventricular (RV)...
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| creator | Blanc, Julie, MD Stos, Bertrand, MD de Montalembert, Mariane, MD Bonnet, Damien, MD, PhD Boudjemline, Younes, MD, PhD |
| description | Background Several adult studies have shown that sickle cell disease is associated with cardiac abnormalities and premature death. The aim of this study was to use speckle-tracking strain, a relatively load independent parameter, to evaluate systolic left ventricular (LV) and right ventricular (RV) function in a pediatric sickle cell disease population. Methods Twenty-eight patients with sickle cell disease (mean age, 10.0 ± 3.6 years; mean body surface area, 1.14 ± 0.27 m2 ) and 29 controls matched for age and body surface area were compared. Cardiac output, LV dimension, wall thickness and circumferential strain, LV and RV longitudinal systolic strain, conventional and tissue Doppler parameters, and pulmonary pressure were assessed. Results LV cardiac output was significantly higher in patients, as were indexed LV systolic diameter, indexed LV mass, and E/E′ septal ratio. Indexed LV diastolic diameter, wall thickness, LV shortening fraction, and global LV longitudinal and circumferential strains were similar in patients and controls. However, their global RV longitudinal strain was significantly lower, although tricuspid annular plane systolic excursion and color-coded tricuspid S-wave velocity were similar. Among patients, 21% had tricuspid regurgitation velocities > 2.5 m/sec, but none had tricuspid regurgitation velocities > 3 m/sec. Indexed LV diastolic dimension and systolic pulmonary artery pressure were significantly higher in patients whose hemoglobin was |
| doi_str_mv | 10.1016/j.echo.2012.01.011 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1009531102</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0894731712000867</els_id><sourcerecordid>1009531102</sourcerecordid><originalsourceid>FETCH-LOGICAL-c411t-c3c8b16ca2050b52bdd81efba568c4822c939d27b9bdf1659d3aab673e6ec3d43</originalsourceid><addsrcrecordid>eNp9kV9rFDEUxYNY7Lb6BXyQPPoya24yf0GEsmotFIqu-hoyN3fdbLMzbZJR9tubYWsf-iBcCIFzTm5-h7HXIJYgoH63WxJux6UUIJcC8sAztgDRNUXddNVzthBtVxaNguaUncW4E0JUrRAv2KmUqgRVNwv29Zv7tU38Jw0pOJy8CXx9iGn0Dvk6BeMGfhX5hU8UyPJ8W22dt4EG_selLV87vPXEV-Q9_-gimUgv2cnG-EivHs5z9uPzp--rL8X1zeXV6uK6wBIgFaiw7aFGI0Ul-kr21rZAm95UdYtlKyV2qrOy6bvebqCuOquM6etGUU2obKnO2dtj7l0Y7yeKSe9dxLyIGWicogYhukoBCJml8ijFMMYYaKPvgtubcMgiPaPUOz2j1DNKLSAPZNObh_yp35N9tPxjlwXvjwLKv_ztKOiIjgYk6wJh0nZ0_8__8MSO3g0Ojb-lA8XdOIUh89OgY_bo9Vzm3CXI3GOb3_8LEjSZUA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1009531102</pqid></control><display><type>article</type><title>Right Ventricular Systolic Strain Is Altered in Children with Sickle Cell Disease</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Blanc, Julie, MD ; Stos, Bertrand, MD ; de Montalembert, Mariane, MD ; Bonnet, Damien, MD, PhD ; Boudjemline, Younes, MD, PhD</creator><creatorcontrib>Blanc, Julie, MD ; Stos, Bertrand, MD ; de Montalembert, Mariane, MD ; Bonnet, Damien, MD, PhD ; Boudjemline, Younes, MD, PhD</creatorcontrib><description>Background Several adult studies have shown that sickle cell disease is associated with cardiac abnormalities and premature death. The aim of this study was to use speckle-tracking strain, a relatively load independent parameter, to evaluate systolic left ventricular (LV) and right ventricular (RV) function in a pediatric sickle cell disease population. Methods Twenty-eight patients with sickle cell disease (mean age, 10.0 ± 3.6 years; mean body surface area, 1.14 ± 0.27 m2 ) and 29 controls matched for age and body surface area were compared. Cardiac output, LV dimension, wall thickness and circumferential strain, LV and RV longitudinal systolic strain, conventional and tissue Doppler parameters, and pulmonary pressure were assessed. Results LV cardiac output was significantly higher in patients, as were indexed LV systolic diameter, indexed LV mass, and E/E′ septal ratio. Indexed LV diastolic diameter, wall thickness, LV shortening fraction, and global LV longitudinal and circumferential strains were similar in patients and controls. However, their global RV longitudinal strain was significantly lower, although tricuspid annular plane systolic excursion and color-coded tricuspid S-wave velocity were similar. Among patients, 21% had tricuspid regurgitation velocities > 2.5 m/sec, but none had tricuspid regurgitation velocities > 3 m/sec. Indexed LV diastolic dimension and systolic pulmonary artery pressure were significantly higher in patients whose hemoglobin was <80 g/L, but parameters of systolic and diastolic LV function were similar. Conclusions In children with sickle cell disease, LV diastolic function is significantly altered, although LV systolic function, evaluated by global longitudinal strain, is normal. In addition, cardiac output is increased, and elevated tricuspid regurgitation velocity is common, whereas it is never found in controls. Most importantly, global RV longitudinal systolic strain is significantly altered.</description><identifier>ISSN: 0894-7317</identifier><identifier>EISSN: 1097-6795</identifier><identifier>DOI: 10.1016/j.echo.2012.01.011</identifier><identifier>PMID: 22341367</identifier><language>eng</language><publisher>United States: Mosby, Inc</publisher><subject>Adolescent ; Age Factors ; Anemia, Sickle Cell - complications ; Anemia, Sickle Cell - diagnosis ; Body Surface Area ; Cardiac Output - physiology ; Cardiovascular ; Case-Control Studies ; Child ; Echocardiography, Doppler - methods ; Echocardiography, Doppler, Pulsed - methods ; Female ; Hemoglobin ; Humans ; Hypertrophy, Left Ventricular - diagnostic imaging ; Hypertrophy, Left Ventricular - etiology ; Hypertrophy, Left Ventricular - physiopathology ; Image Interpretation, Computer-Assisted ; Male ; Myocardial Contraction - physiology ; Myocardial function ; Observer Variation ; Prognosis ; Reference Values ; Risk Assessment ; Severity of Illness Index ; Sex Factors ; Statistics, Nonparametric ; Stroke Volume - physiology ; Tricuspid Valve Insufficiency - diagnostic imaging ; Tricuspid Valve Insufficiency - etiology ; Tricuspid Valve Insufficiency - physiopathology ; Two-dimensional speckle-tracking strain ; Ventricular Dysfunction, Left - diagnostic imaging ; Ventricular Dysfunction, Left - etiology ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Journal of the American Society of Echocardiography, 2012-05, Vol.25 (5), p.511-517</ispartof><rights>American Society of Echocardiography</rights><rights>2012 American Society of Echocardiography</rights><rights>Copyright © 2012 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c411t-c3c8b16ca2050b52bdd81efba568c4822c939d27b9bdf1659d3aab673e6ec3d43</citedby><cites>FETCH-LOGICAL-c411t-c3c8b16ca2050b52bdd81efba568c4822c939d27b9bdf1659d3aab673e6ec3d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0894731712000867$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22341367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Blanc, Julie, MD</creatorcontrib><creatorcontrib>Stos, Bertrand, MD</creatorcontrib><creatorcontrib>de Montalembert, Mariane, MD</creatorcontrib><creatorcontrib>Bonnet, Damien, MD, PhD</creatorcontrib><creatorcontrib>Boudjemline, Younes, MD, PhD</creatorcontrib><title>Right Ventricular Systolic Strain Is Altered in Children with Sickle Cell Disease</title><title>Journal of the American Society of Echocardiography</title><addtitle>J Am Soc Echocardiogr</addtitle><description>Background Several adult studies have shown that sickle cell disease is associated with cardiac abnormalities and premature death. The aim of this study was to use speckle-tracking strain, a relatively load independent parameter, to evaluate systolic left ventricular (LV) and right ventricular (RV) function in a pediatric sickle cell disease population. Methods Twenty-eight patients with sickle cell disease (mean age, 10.0 ± 3.6 years; mean body surface area, 1.14 ± 0.27 m2 ) and 29 controls matched for age and body surface area were compared. Cardiac output, LV dimension, wall thickness and circumferential strain, LV and RV longitudinal systolic strain, conventional and tissue Doppler parameters, and pulmonary pressure were assessed. Results LV cardiac output was significantly higher in patients, as were indexed LV systolic diameter, indexed LV mass, and E/E′ septal ratio. Indexed LV diastolic diameter, wall thickness, LV shortening fraction, and global LV longitudinal and circumferential strains were similar in patients and controls. However, their global RV longitudinal strain was significantly lower, although tricuspid annular plane systolic excursion and color-coded tricuspid S-wave velocity were similar. Among patients, 21% had tricuspid regurgitation velocities > 2.5 m/sec, but none had tricuspid regurgitation velocities > 3 m/sec. Indexed LV diastolic dimension and systolic pulmonary artery pressure were significantly higher in patients whose hemoglobin was <80 g/L, but parameters of systolic and diastolic LV function were similar. Conclusions In children with sickle cell disease, LV diastolic function is significantly altered, although LV systolic function, evaluated by global longitudinal strain, is normal. In addition, cardiac output is increased, and elevated tricuspid regurgitation velocity is common, whereas it is never found in controls. Most importantly, global RV longitudinal systolic strain is significantly altered.</description><subject>Adolescent</subject><subject>Age Factors</subject><subject>Anemia, Sickle Cell - complications</subject><subject>Anemia, Sickle Cell - diagnosis</subject><subject>Body Surface Area</subject><subject>Cardiac Output - physiology</subject><subject>Cardiovascular</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Echocardiography, Doppler - methods</subject><subject>Echocardiography, Doppler, Pulsed - methods</subject><subject>Female</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Hypertrophy, Left Ventricular - diagnostic imaging</subject><subject>Hypertrophy, Left Ventricular - etiology</subject><subject>Hypertrophy, Left Ventricular - physiopathology</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Male</subject><subject>Myocardial Contraction - physiology</subject><subject>Myocardial function</subject><subject>Observer Variation</subject><subject>Prognosis</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Severity of Illness Index</subject><subject>Sex Factors</subject><subject>Statistics, Nonparametric</subject><subject>Stroke Volume - physiology</subject><subject>Tricuspid Valve Insufficiency - diagnostic imaging</subject><subject>Tricuspid Valve Insufficiency - etiology</subject><subject>Tricuspid Valve Insufficiency - physiopathology</subject><subject>Two-dimensional speckle-tracking strain</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - etiology</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0894-7317</issn><issn>1097-6795</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV9rFDEUxYNY7Lb6BXyQPPoya24yf0GEsmotFIqu-hoyN3fdbLMzbZJR9tubYWsf-iBcCIFzTm5-h7HXIJYgoH63WxJux6UUIJcC8sAztgDRNUXddNVzthBtVxaNguaUncW4E0JUrRAv2KmUqgRVNwv29Zv7tU38Jw0pOJy8CXx9iGn0Dvk6BeMGfhX5hU8UyPJ8W22dt4EG_selLV87vPXEV-Q9_-gimUgv2cnG-EivHs5z9uPzp--rL8X1zeXV6uK6wBIgFaiw7aFGI0Ul-kr21rZAm95UdYtlKyV2qrOy6bvebqCuOquM6etGUU2obKnO2dtj7l0Y7yeKSe9dxLyIGWicogYhukoBCJml8ijFMMYYaKPvgtubcMgiPaPUOz2j1DNKLSAPZNObh_yp35N9tPxjlwXvjwLKv_ztKOiIjgYk6wJh0nZ0_8__8MSO3g0Ojb-lA8XdOIUh89OgY_bo9Vzm3CXI3GOb3_8LEjSZUA</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Blanc, Julie, MD</creator><creator>Stos, Bertrand, MD</creator><creator>de Montalembert, Mariane, MD</creator><creator>Bonnet, Damien, MD, PhD</creator><creator>Boudjemline, Younes, MD, PhD</creator><general>Mosby, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Right Ventricular Systolic Strain Is Altered in Children with Sickle Cell Disease</title><author>Blanc, Julie, MD ; Stos, Bertrand, MD ; de Montalembert, Mariane, MD ; Bonnet, Damien, MD, PhD ; Boudjemline, Younes, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c411t-c3c8b16ca2050b52bdd81efba568c4822c939d27b9bdf1659d3aab673e6ec3d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adolescent</topic><topic>Age Factors</topic><topic>Anemia, Sickle Cell - complications</topic><topic>Anemia, Sickle Cell - diagnosis</topic><topic>Body Surface Area</topic><topic>Cardiac Output - physiology</topic><topic>Cardiovascular</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Echocardiography, Doppler - methods</topic><topic>Echocardiography, Doppler, Pulsed - methods</topic><topic>Female</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Hypertrophy, Left Ventricular - diagnostic imaging</topic><topic>Hypertrophy, Left Ventricular - etiology</topic><topic>Hypertrophy, Left Ventricular - physiopathology</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Male</topic><topic>Myocardial Contraction - physiology</topic><topic>Myocardial function</topic><topic>Observer Variation</topic><topic>Prognosis</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Severity of Illness Index</topic><topic>Sex Factors</topic><topic>Statistics, Nonparametric</topic><topic>Stroke Volume - physiology</topic><topic>Tricuspid Valve Insufficiency - diagnostic imaging</topic><topic>Tricuspid Valve Insufficiency - etiology</topic><topic>Tricuspid Valve Insufficiency - physiopathology</topic><topic>Two-dimensional speckle-tracking strain</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - etiology</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Blanc, Julie, MD</creatorcontrib><creatorcontrib>Stos, Bertrand, MD</creatorcontrib><creatorcontrib>de Montalembert, Mariane, MD</creatorcontrib><creatorcontrib>Bonnet, Damien, MD, PhD</creatorcontrib><creatorcontrib>Boudjemline, Younes, MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Society of Echocardiography</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Blanc, Julie, MD</au><au>Stos, Bertrand, MD</au><au>de Montalembert, Mariane, MD</au><au>Bonnet, Damien, MD, PhD</au><au>Boudjemline, Younes, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Right Ventricular Systolic Strain Is Altered in Children with Sickle Cell Disease</atitle><jtitle>Journal of the American Society of Echocardiography</jtitle><addtitle>J Am Soc Echocardiogr</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>25</volume><issue>5</issue><spage>511</spage><epage>517</epage><pages>511-517</pages><issn>0894-7317</issn><eissn>1097-6795</eissn><abstract>Background Several adult studies have shown that sickle cell disease is associated with cardiac abnormalities and premature death. The aim of this study was to use speckle-tracking strain, a relatively load independent parameter, to evaluate systolic left ventricular (LV) and right ventricular (RV) function in a pediatric sickle cell disease population. Methods Twenty-eight patients with sickle cell disease (mean age, 10.0 ± 3.6 years; mean body surface area, 1.14 ± 0.27 m2 ) and 29 controls matched for age and body surface area were compared. Cardiac output, LV dimension, wall thickness and circumferential strain, LV and RV longitudinal systolic strain, conventional and tissue Doppler parameters, and pulmonary pressure were assessed. Results LV cardiac output was significantly higher in patients, as were indexed LV systolic diameter, indexed LV mass, and E/E′ septal ratio. Indexed LV diastolic diameter, wall thickness, LV shortening fraction, and global LV longitudinal and circumferential strains were similar in patients and controls. However, their global RV longitudinal strain was significantly lower, although tricuspid annular plane systolic excursion and color-coded tricuspid S-wave velocity were similar. Among patients, 21% had tricuspid regurgitation velocities > 2.5 m/sec, but none had tricuspid regurgitation velocities > 3 m/sec. Indexed LV diastolic dimension and systolic pulmonary artery pressure were significantly higher in patients whose hemoglobin was <80 g/L, but parameters of systolic and diastolic LV function were similar. Conclusions In children with sickle cell disease, LV diastolic function is significantly altered, although LV systolic function, evaluated by global longitudinal strain, is normal. In addition, cardiac output is increased, and elevated tricuspid regurgitation velocity is common, whereas it is never found in controls. Most importantly, global RV longitudinal systolic strain is significantly altered.</abstract><cop>United States</cop><pub>Mosby, Inc</pub><pmid>22341367</pmid><doi>10.1016/j.echo.2012.01.011</doi><tpages>7</tpages></addata></record> |
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| subjects | Adolescent Age Factors Anemia, Sickle Cell - complications Anemia, Sickle Cell - diagnosis Body Surface Area Cardiac Output - physiology Cardiovascular Case-Control Studies Child Echocardiography, Doppler - methods Echocardiography, Doppler, Pulsed - methods Female Hemoglobin Humans Hypertrophy, Left Ventricular - diagnostic imaging Hypertrophy, Left Ventricular - etiology Hypertrophy, Left Ventricular - physiopathology Image Interpretation, Computer-Assisted Male Myocardial Contraction - physiology Myocardial function Observer Variation Prognosis Reference Values Risk Assessment Severity of Illness Index Sex Factors Statistics, Nonparametric Stroke Volume - physiology Tricuspid Valve Insufficiency - diagnostic imaging Tricuspid Valve Insufficiency - etiology Tricuspid Valve Insufficiency - physiopathology Two-dimensional speckle-tracking strain Ventricular Dysfunction, Left - diagnostic imaging Ventricular Dysfunction, Left - etiology Ventricular Dysfunction, Left - physiopathology |
| title | Right Ventricular Systolic Strain Is Altered in Children with Sickle Cell Disease |
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