Immunohistological pointers to a possible role for excessive cathelicidin (LL-37) expression by apocrine sweat glands in the pathogenesis of hidradenitis suppurativa/acne inversa

Summary Background The cause of follicular occlusion, a key early event in the pathogenesis of hidradenitis suppurativa (HS), also known as acne inversa, remains unknown. Objectives To identify changes, if any, in the antimicrobial peptide (AMP) and cytokine expression profile of HS affected human...

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Veröffentlicht in:	British journal of dermatology (1951) 2012-05, Vol.166 (5), p.1023-1034
Hauptverfasser:	Emelianov, V.U., Bechara, F.G., Gläser, R., Langan, E.A., Taungjaruwinai, W.M., Schröder, J.M., Meyer, K.C., Paus, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acne Adult alpha-MSH - metabolism Antimicrobial Cationic Peptides - metabolism Antimicrobial peptides beta-Defensins - metabolism Biological and medical sciences Case-Control Studies Chemotactic Factors - metabolism Dermatology Dermis Dermis - metabolism Epidermis Epidermis - metabolism Epithelium Female Hidradenitis Suppurativa - etiology Hidradenitis Suppurativa - metabolism Humans Immunohistochemistry Immunoreactivity Inflammation Interleukin-8 - metabolism Leukocyte migration Lysozyme Macrophage migration inhibitory factor Male Medical sciences Menopause Middle Aged Migration inhibitory factor Muramidase - metabolism Occlusion Pathogenesis S100 Calcium Binding Protein A7 S100 Proteins - metabolism Skin diseases Skin involvement in other diseases. Miscellaneous. General aspects Sweat Sweat gland Sweat Glands - metabolism Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF Tumors Up-Regulation Young Adult
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