Biological and functional characteristics of a novel low-molecular weight antagonist of glucose-dependent insulinotropic polypeptide receptor, SKL-14959, in vitro and in vivo

Aim: We recently discovered a glucose‐dependent insulinotropic polypeptide (GIP) receptor antagonist, SKL‐14959. GIP plays a role in the glucose and lipid metabolism, and is associated with obesity and insulin resistance. Therefore, we aimed to ascertain the inhibitory potency and glucose and lipid...

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Veröffentlicht in:Diabetes, obesity & metabolism obesity & metabolism, 2012-06, Vol.14 (6), p.511-517
Hauptverfasser: Nakamura, T., Tanimoto, H., Mizuno, Y., Tsubamoto, Y., Noda, H.
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Sprache:eng
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