Administration of poly(I:C) improved dermatophagoides farinae -induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance
Highlights ► Suppression of Df-induced AD-like skin lesions in NC/Nga mice model by poly(I:C). ► Poly(I:C) regulated the balance of Th1/Th2 cytokine production. ► Poly(I:C) might be a useful immunomodulatory agent for the treatment of human AD.
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| Veröffentlicht in: | Vaccine 2012-03, Vol.30 (14), p.2405-2410 |
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| container_title | Vaccine |
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| creator | Kim, Chang-Hyun Park, Chan Do Lee, Ai-Young |
| description | Highlights ► Suppression of Df-induced AD-like skin lesions in NC/Nga mice model by poly(I:C). ► Poly(I:C) regulated the balance of Th1/Th2 cytokine production. ► Poly(I:C) might be a useful immunomodulatory agent for the treatment of human AD. |
| doi_str_mv | 10.1016/j.vaccine.2011.11.049 |
| format | Article |
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All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-a2680a3b68500366abee38479003c04a119e127380a9a32d94052a70ab6b5ee23</citedby><cites>FETCH-LOGICAL-c510t-a2680a3b68500366abee38479003c04a119e127380a9a32d94052a70ab6b5ee23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vaccine.2011.11.049$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64387</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22119586$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Chang-Hyun</creatorcontrib><creatorcontrib>Park, Chan Do</creatorcontrib><creatorcontrib>Lee, Ai-Young</creatorcontrib><title>Administration of poly(I:C) improved dermatophagoides farinae -induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>Highlights ► Suppression of Df-induced AD-like skin lesions in NC/Nga mice model by poly(I:C). ► Poly(I:C) regulated the balance of Th1/Th2 cytokine production. ► Poly(I:C) might be a useful immunomodulatory agent for the treatment of human AD.</description><subject>Allergy and Immunology</subject><subject>Animals</subject><subject>Atopic dermatitis</subject><subject>blood serum</subject><subject>Chemokines</subject><subject>Cytokines</subject><subject>Cytokines - biosynthesis</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dermatitis, Atopic - pathology</subject><subject>Dermatitis, Atopic - prevention & control</subject><subject>Dermatophagoides</subject><subject>Dermatophagoides farinae</subject><subject>Dermatophagoides farinae - immunology</subject><subject>eosinophils</subject><subject>Eosinophils - immunology</subject><subject>eotaxin</subject><subject>gamma -Interferon</subject><subject>Helper cells</subject><subject>humans</subject><subject>Hypersensitivity</subject><subject>Immunoglobulin E</subject><subject>Immunoglobulin E - blood</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunologic Factors - administration & dosage</subject><subject>Immunologic Factors - pharmacology</subject><subject>Immunomodulation</subject><subject>immunostimulants</subject><subject>Inflammation</subject><subject>interferon-gamma</subject><subject>Leukocytes (eosinophilic)</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Mast cells</subject><subject>Mast Cells - immunology</subject><subject>Mice</subject><subject>NC/Nga mice</subject><subject>Poly I-C - administration & dosage</subject><subject>Poly I-C - pharmacology</subject><subject>Polyinosinic–polycytidylic acid</subject><subject>Skin - drug effects</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>skin lesions</subject><subject>Spleen</subject><subject>splenocytes</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Th1-Th2 Balance - drug effects</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - immunology</subject><subject>Vaccine</subject><subject>vaccines</subject><issn>0264-410X</issn><issn>1873-2518</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk2P0zAQhiMEYsvCTwB8XA5pbeejCQfQqlpgpdVy2K7EzZo403baJC52Uql_ht-6E7XsgQuSJdvy43c-3omi90pOlVT5bDs9gLXU4VRLpaa8ZFq-iCaqmCexzlTxMppInadxquSvi-hNCFspZZao8nV0obVSZVbkk-jPdd1SR6H30JPrhFuJvWuOV7efF58EtXvvDliLGn0LvdtvYO2oxiBW4KkDFDF19WCZGF_JnkHqKcQN7VCEHXWiwcDSQfDxfjG7X4NoyaKojqLfoPC4Hprn4MuNmi03WlTQQGfxbfRqBU3Ad-f9Mnr8drNc_Ijvfn6_XVzfxTZTso9B54WEpMqLTMokz6FCTIp0XvLNyhS4WlR6njBUQqLrMpWZhrmEKq8yRJ1cRlcnXS7494ChNy0Fiw0ngW4IRklZFKnWRclodkKtdyF4XJm9pxb8kSEzWmO25myNGa0xvNga_vfhHGKoWqyff_31goGPJ2AFzsDaUzCPD6zAJalUM8DE1xOB3IoDoTfBEnKbavJoe1M7-m8SX_5RsA3bb6HZ4RHD1g2-4z4bZYI20jyMEzQOkGLNIkl18gQ9BsCa</recordid><startdate>20120323</startdate><enddate>20120323</enddate><creator>Kim, Chang-Hyun</creator><creator>Park, Chan Do</creator><creator>Lee, Ai-Young</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20120323</creationdate><title>Administration of poly(I:C) improved dermatophagoides farinae -induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance</title><author>Kim, Chang-Hyun ; Park, Chan Do ; Lee, Ai-Young</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-a2680a3b68500366abee38479003c04a119e127380a9a32d94052a70ab6b5ee23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Allergy and Immunology</topic><topic>Animals</topic><topic>Atopic dermatitis</topic><topic>blood serum</topic><topic>Chemokines</topic><topic>Cytokines</topic><topic>Cytokines - biosynthesis</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dermatitis, Atopic - pathology</topic><topic>Dermatitis, Atopic - prevention & control</topic><topic>Dermatophagoides</topic><topic>Dermatophagoides farinae</topic><topic>Dermatophagoides farinae - immunology</topic><topic>eosinophils</topic><topic>Eosinophils - immunology</topic><topic>eotaxin</topic><topic>gamma -Interferon</topic><topic>Helper cells</topic><topic>humans</topic><topic>Hypersensitivity</topic><topic>Immunoglobulin E</topic><topic>Immunoglobulin E - blood</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunologic Factors - administration & dosage</topic><topic>Immunologic Factors - pharmacology</topic><topic>Immunomodulation</topic><topic>immunostimulants</topic><topic>Inflammation</topic><topic>interferon-gamma</topic><topic>Leukocytes (eosinophilic)</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Mast cells</topic><topic>Mast Cells - immunology</topic><topic>Mice</topic><topic>NC/Nga mice</topic><topic>Poly I-C - administration & dosage</topic><topic>Poly I-C - pharmacology</topic><topic>Polyinosinic–polycytidylic acid</topic><topic>Skin - drug effects</topic><topic>Skin - pathology</topic><topic>Skin diseases</topic><topic>skin lesions</topic><topic>Spleen</topic><topic>splenocytes</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th1-Th2 Balance - drug effects</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><topic>Vaccine</topic><topic>vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Chang-Hyun</creatorcontrib><creatorcontrib>Park, Chan Do</creatorcontrib><creatorcontrib>Lee, Ai-Young</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Vaccine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Chang-Hyun</au><au>Park, Chan Do</au><au>Lee, Ai-Young</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Administration of poly(I:C) improved dermatophagoides farinae -induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2012-03-23</date><risdate>2012</risdate><volume>30</volume><issue>14</issue><spage>2405</spage><epage>2410</epage><pages>2405-2410</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><abstract>Highlights ► Suppression of Df-induced AD-like skin lesions in NC/Nga mice model by poly(I:C). ► Poly(I:C) regulated the balance of Th1/Th2 cytokine production. ► Poly(I:C) might be a useful immunomodulatory agent for the treatment of human AD.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>22119586</pmid><doi>10.1016/j.vaccine.2011.11.049</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Allergy and Immunology Animals Atopic dermatitis blood serum Chemokines Cytokines Cytokines - biosynthesis Dermatitis, Atopic - immunology Dermatitis, Atopic - pathology Dermatitis, Atopic - prevention & control Dermatophagoides Dermatophagoides farinae Dermatophagoides farinae - immunology eosinophils Eosinophils - immunology eotaxin gamma -Interferon Helper cells humans Hypersensitivity Immunoglobulin E Immunoglobulin E - blood Immunoglobulin E - immunology Immunologic Factors - administration & dosage Immunologic Factors - pharmacology Immunomodulation immunostimulants Inflammation interferon-gamma Leukocytes (eosinophilic) Lymphocytes T Male Mast cells Mast Cells - immunology Mice NC/Nga mice Poly I-C - administration & dosage Poly I-C - pharmacology Polyinosinic–polycytidylic acid Skin - drug effects Skin - pathology Skin diseases skin lesions Spleen splenocytes Th1 Cells - drug effects Th1 Cells - immunology Th1-Th2 Balance - drug effects Th2 Cells - drug effects Th2 Cells - immunology Vaccine vaccines |
| title | Administration of poly(I:C) improved dermatophagoides farinae -induced atopic dermatitis-like skin lesions in NC/Nga mice by the regulation of Th1/Th2 balance |
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