Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors

A variety of social behaviors like intermale aggression, fear, and mating rituals are important for sustenance of a species. In mice, these behaviors have been implicated to be mediated by peptide pheromones that are sensed by a class of G protein-coupled receptors, vomeronasal receptor type 2 (V2Rs...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (40), p.16651-16656
Hauptverfasser:	Dey, Sandeepa, Matsunami, Hiroaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Aggression Animals Base Sequence Biological Sciences Blotting, Western Calreticulin Calreticulin - genetics Calreticulin - metabolism Cell Line Cell lines Cell membranes Cells Chaperones chemoreceptors Data processing DNA Primers - genetics eukaryotic cells Fear fearfulness Fluorescence G protein-coupled receptors Gene expression Gene Knockdown Techniques HEK293 cells Humans Immunohistochemistry Immunoprecipitation In Situ Hybridization Ligands Mating Mice Mice, Inbred C57BL Molecular Chaperones - metabolism Molecular Sequence Data Neurons Odorant receptors Pheromone receptors Pheromones Protein transport Proteins Receptors Receptors, Pheromone - metabolism Reverse Transcriptase Polymerase Chain Reaction Sensory neurons Sequence Analysis, DNA Social Behavior T cell receptors Vomeronasal organ Vomeronasal Organ - metabolism Vomeronasal system
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