Transition From Obesity to Metabolic Syndrome Is Associated With Altered Myocardial Autophagy and Apoptosis

OBJECTIVE—Transition from obesity to metabolic-syndrome (MetS) promotes cardiovascular diseases, but the underlying cardiac pathophysiological mechanisms are incompletely understood. We tested the hypothesis that development of insulin resistance and MetS is associated with impaired myocardial cellu...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2012-05, Vol.32 (5), p.1132-1141
Hauptverfasser:	Li, Zi-Lun, Woollard, John R, Ebrahimi, Behzad, Crane, John A, Jordan, Kyra L, Lerman, Amir, Wang, Shen-Ming, Lerman, Lilach O
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Atherosclerosis (general aspects, experimental research) Autophagy Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Coronary heart disease Diet, Atherogenic - adverse effects Disease Models, Animal Disease Progression Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Heart Insulin Resistance Medical sciences Metabolic Syndrome - etiology Metabolic Syndrome - metabolism Metabolic Syndrome - pathology Myocardium - metabolism Myocardium - pathology Obesity - complications Obesity - metabolism Obesity - pathology Oxidative Stress Swine
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