Hydrophobic poly (amino acid) modified PEI mediated delivery of rev-casp-3 for cancer therapy

Abstract Recent studies in amphiphilic cationic polymers have demonstrated their potential as gene carriers with high transfection efficiency and low cytotoxicity in the in vitro settings to deliver drug, siRNA and plasmid DNA. Yet their safety and efficacy in vivo remain to be a challenge, and requ...

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Veröffentlicht in:	Biomaterials 2012-06, Vol.33 (18), p.4589-4596
Hauptverfasser:	Fu, Chunling, Lin, Lin, Shi, Hengliang, Zheng, Daxue, Wang, Wei, Gao, Shiqian, Zhao, Yifei, Tian, Huayu, Zhu, Xiaojuan, Chen, Xuesi
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Amino Acids - chemistry Amphiphilic cationic polymer Animals Biocompatibility Blotting, Western Cancer therapy Caspase 3 - genetics Caspase 3 - physiology Cell Line, Tumor Cells, Cultured Dentistry Electrophoretic Mobility Shift Assay Erythrocytes - drug effects Female Flow Cytometry Genetic Therapy - methods Genetic Vectors - administration & dosage Genetic Vectors - adverse effects Genetic Vectors - chemistry HeLa Cells Humans Hydrophobic and Hydrophilic Interactions Immunohistochemistry In Situ Nick-End Labeling Interferon-gamma - blood Mice Mice, Inbred BALB C Mice, Nude Plasmids Polyethyleneimine - chemistry Polymers - administration & dosage Polymers - adverse effects Polymers - chemistry PP80 Rabbits Rev-casp-3 Uterine Cervical Neoplasms - blood Uterine Cervical Neoplasms - therapy Xenograft Model Antitumor Assays
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