Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma
Dogs with and without lymphoma have undergone hematopoietic cell transplantation in a research setting for decades. North Carolina State University is currently treating dogs with B- and T-cell lymphoma in a clinical setting with autologous peripheral blood progenitor cell transplants, using periphe...
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| Veröffentlicht in: | Veterinary pathology 2012-03, Vol.49 (2), p.341-343 |
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| container_title | Veterinary pathology |
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| creator | Escobar, C. Grindem, C. Neel, J. A. Suter, S. E. |
| description | Dogs with and without lymphoma have undergone hematopoietic cell transplantation in a research setting for decades. North Carolina State University is currently treating dogs with B- and T-cell lymphoma in a clinical setting with autologous peripheral blood progenitor cell transplants, using peripheral blood CD34+ progenitor cells harvested using an apheresis machine. Complete blood counts were performed daily for 15 to 19 days posttransplantation to monitor peripheral blood cell nadirs and subsequent CD34+ cell engraftment. This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment. All peripheral blood cell lines, excluding red blood cells, experienced grade 4 toxicities. All dogs had ≥ 500 neutrophils/μl by day 12, while thrombocytopenia persisted for many weeks. All dogs were clinically normal at discharge. |
| doi_str_mv | 10.1177/0300985811410721 |
| format | Article |
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This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment. All peripheral blood cell lines, excluding red blood cells, experienced grade 4 toxicities. All dogs had ≥ 500 neutrophils/μl by day 12, while thrombocytopenia persisted for many weeks. 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E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma</atitle><jtitle>Veterinary pathology</jtitle><addtitle>Vet Pathol</addtitle><date>2012-03-01</date><risdate>2012</risdate><volume>49</volume><issue>2</issue><spage>341</spage><epage>343</epage><pages>341-343</pages><issn>0300-9858</issn><eissn>1544-2217</eissn><abstract>Dogs with and without lymphoma have undergone hematopoietic cell transplantation in a research setting for decades. North Carolina State University is currently treating dogs with B- and T-cell lymphoma in a clinical setting with autologous peripheral blood progenitor cell transplants, using peripheral blood CD34+ progenitor cells harvested using an apheresis machine. 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| fulltext | fulltext |
| identifier | ISSN: 0300-9858 |
| ispartof | Veterinary pathology, 2012-03, Vol.49 (2), p.341-343 |
| issn | 0300-9858 1544-2217 |
| language | eng |
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| source | MEDLINE; SAGE Complete A-Z List |
| subjects | Animals Antigens, CD34 - metabolism Blood Cell Count - veterinary Bone Marrow - radiation effects Dog Diseases - therapy Dogs Graft Survival Hematopoietic Stem Cell Transplantation - methods Hematopoietic Stem Cell Transplantation - veterinary Lymphoma - therapy Lymphoma - veterinary Transplantation, Autologous Whole-Body Irradiation - adverse effects Whole-Body Irradiation - veterinary |
| title | Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma |
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