Transcript signature predicts tissue NK cell content and defines renal cell carcinoma subgroups independent of TNM staging

Clear cell renal cell carcinoma (ccRCC) is an aggressive and difficult to manage cancer. Immunotherapy has the potential to induce long-lasting regression in a small group of patients. However, severe side effects limit broad application which highlights the need for a marker to distinguish responde...

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Veröffentlicht in:	Journal of molecular medicine (Berlin, Germany) Germany), 2012, Vol.90 (1), p.55-66
Hauptverfasser:	Eckl, Judith, Buchner, Alexander, Prinz, Petra U., Riesenberg, Rainer, Siegert, Sabine I., Kammerer, Robert, Nelson, Peter J., Noessner, Elfriede
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antitumor activity Biological and medical sciences Biomedical and Life Sciences Biomedicine Carcinoma, Renal Cell - classification Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - mortality Carcinoma, Renal Cell - pathology Chemokine CX3CL1 - genetics Clear cells CX3C Chemokine Receptor 1 CX3CR1 protein Differentiation Effector cells Female Flow cytometry Gene Expression Profiling General aspects Human Genetics Humans Immunophenotyping Immunotherapy Interleukin 2 Internal Medicine Kidney Neoplasms - classification Kidney Neoplasms - genetics Kidney Neoplasms - mortality Kidney Neoplasms - pathology Kidneys Killer Cells, Natural - pathology Lymph nodes Lymphocytes Lymphocytes, Tumor-Infiltrating - pathology Male Medical sciences Metastases Middle Aged Molecular Medicine Natural Cytotoxicity Triggering Receptor 1 - genetics Natural killer cells Neoplasm Staging Nephrology. Urinary tract diseases Neural networks Original Paper Perforin Perforin - genetics Polymerase chain reaction Prognosis Receptors, Chemokine - genetics renal cell carcinoma RNA RNA-directed DNA polymerase Side effects Solid tumors Transcription Translation Tumors Tumors of the urinary system
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