Concise Synthesis of 2-Benzazepine Derivatives and Their Biological Activity

2-Benzazepines, which are potentially good candidates for new drug therapies to treat skin wounds, were readily prepared from substituted cinnamylamide via an intramolecular Friedel–Crafts reaction. With few steps and effective reactions, the procedure enables a rapid derivatization of 2-benzazepine...

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Veröffentlicht in:	Journal of organic chemistry 2012-04, Vol.77 (8), p.4017-4028
Hauptverfasser:	So, Masahiro, Kotake, Tomoko, Matsuura, Kenji, Inui, Makoto, Kamimura, Akio
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Benzazepines - chemical synthesis Benzazepines - chemistry Benzazepines - pharmacology Chemistry Cyclization Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Heterocyclic compounds with only one n hetero atom and condensed derivatives Molecular Structure Noncondensed benzenic compounds Organic chemistry Preparations and properties Stereoisomerism
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