Subchronic microcystin-lr exposure increased hepatic apoptosis and induced compensatory mechanisms in mice

Acute lethal cytotoxicity of microcystin‐LR (MC‐LR), a toxin produced by fresh‐water cyanobacteria, has been attributed to protein phosphatases type 1 and type 2A (PP1/PP2A) inhibition and reactive oxygen species (ROS) generation. However, the effects and molecular mechanisms of prolonged, sublethal...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2012-03, Vol.26 (4), p.131-138
Hauptverfasser:	Lezcano, Noelia, Sedán, Daniela, Lucotti, Ignacio, Giannuzzi, Leda, Vittone, Leticia, Andrinolo, Darío, Mundiña-Weilenmann, Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Enzyme Activation - drug effects Heart - drug effects Injections, Intraperitoneal Kidney - drug effects Kidney - metabolism Kidney - pathology Liver - drug effects Liver - enzymology Liver - metabolism Liver - pathology Male Mice Microcystin Microcystins - administration & dosage Microcystins - isolation & purification Microcystins - toxicity Myocardium - metabolism Myocardium - pathology p38 Mitogen-Activated Protein Kinases - metabolism Phosphatase Activity Prolonged Exposure Protein Phosphatase 1 - antagonists & inhibitors Protein Phosphatase 1 - metabolism Protein Phosphatase 2 - antagonists & inhibitors Protein Phosphatase 2 - metabolism Reactive Oxygen Species - metabolism Signal Transduction - drug effects Signaling Pathways Tubulin - metabolism
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