Lymphatic transport and catabolism of therapeutic proteins after subcutaneous administration to rats and dogs

The mechanism underlying subcutaneous absorption of macromolecules and factors that can influence this process were studied in rats using PEGylated erythropoietins (EPOs) as model compounds. Using a thoracic lymph duct cannulation (LDC) model, we showed that PEGylated EPO was absorbed from the subcu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Drug metabolism and disposition 2012-05, Vol.40 (5), p.952-962
Hauptverfasser:	Wang, Weirong, Chen, Nancy, Shen, Xiaolan, Cunningham, Paul, Fauty, Scott, Michel, Kimberly, Wang, Bo, Hong, Xuening, Adreani, Christine, Nunes, Christian N, Johnson, Chris V, Yin, Kuo-Chang, Groff, Michelle, Zou, Yan, Liu, Liming, Hamuro, Lora, Prueksaritanont, Thomayant
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Adipose Tissue - metabolism Animals Biological Availability Biological Transport Dogs Drug Discovery Electrophoresis, Polyacrylamide Gel Erythropoietin - administration & dosage Erythropoietin - blood Erythropoietin - metabolism Erythropoietin - pharmacokinetics Injections, Subcutaneous Lymph Nodes - metabolism Lymphatic System - metabolism Male Motor Activity - physiology Polyethylene Glycols - administration & dosage Polyethylene Glycols - metabolism Polyethylene Glycols - pharmacokinetics Rats Rats, Sprague-Dawley Recombinant Proteins - administration & dosage Recombinant Proteins - blood Recombinant Proteins - metabolism Recombinant Proteins - pharmacokinetics Species Specificity Time Factors Tissue Distribution
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!