Multicenter study of serous cystic neoplasm of the Japan pancreas society
There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) of the pancreas. The frequency of malignancy and surgical indication of SCN are not determined yet. In this multi-institutional study of the Japan Pancreas Society, a total of 172 patients with SCN were enrolled....
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| Veröffentlicht in: | Pancreas 2012-04, Vol.41 (3), p.380-387 |
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| creator | Kimura, Wataru Moriya, Toshiyuki Hirai, Ichiro Hanada, Keiji Abe, Hideki Yanagisawa, Akio Fukushima, Noriyoshi Ohike, Nobuyuki Shimizu, Michio Hatori, Takashi Fujita, Naotaka Maguchi, Hiroyuki Shimizu, Yasuhiro Yamao, Kenji Sasaki, Tamito Naito, Yoshiki Tanno, Satoshi Tobita, Kosuke Tanaka, Masao |
| description | There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) of the pancreas. The frequency of malignancy and surgical indication of SCN are not determined yet.
In this multi-institutional study of the Japan Pancreas Society, a total of 172 patients with SCN were enrolled. The mean follow-up period was 4.5 years. Surgical resection was performed in 90 patients, whereas the remaining 82 were simply observed.
Of all patients, 20% were symptomatic. The tumor was located in the pancreatic head (39%), body (35%), and tail (22%). The mean diameter of the tumor was 4.1 cm. None of the patients showed distant or lymph node metastasis except for liver metastasis found in 2 patients (1.2%). No patient died during the follow-up. The preoperative diagnosis did not correctly identify SCN in 57 (63%) of 90 resected cases. A honeycomb appearance, which is one of the most characteristic findings of SCN, could be diagnosed better by endoscopic ultrasonography than by other imaging diagnostic modalities.
Surgical resection should be considered only when clear distinction from other surgical diseases is difficult, when symptoms or mass effects are present, and when the tumor size is large. |
| doi_str_mv | 10.1097/MPA.0b013e31822a27db |
| format | Article |
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In this multi-institutional study of the Japan Pancreas Society, a total of 172 patients with SCN were enrolled. The mean follow-up period was 4.5 years. Surgical resection was performed in 90 patients, whereas the remaining 82 were simply observed.
Of all patients, 20% were symptomatic. The tumor was located in the pancreatic head (39%), body (35%), and tail (22%). The mean diameter of the tumor was 4.1 cm. None of the patients showed distant or lymph node metastasis except for liver metastasis found in 2 patients (1.2%). No patient died during the follow-up. The preoperative diagnosis did not correctly identify SCN in 57 (63%) of 90 resected cases. A honeycomb appearance, which is one of the most characteristic findings of SCN, could be diagnosed better by endoscopic ultrasonography than by other imaging diagnostic modalities.
Surgical resection should be considered only when clear distinction from other surgical diseases is difficult, when symptoms or mass effects are present, and when the tumor size is large.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/MPA.0b013e31822a27db</identifier><identifier>PMID: 22415666</identifier><language>eng</language><publisher>United States</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cystadenoma, Mucinous - secondary ; Cystadenoma, Mucinous - surgery ; Cystadenoma, Serous - secondary ; Cystadenoma, Serous - surgery ; Diagnosis, Differential ; Diagnostic Imaging ; Female ; Humans ; Japan ; Liver Neoplasms - secondary ; Male ; Middle Aged ; Pancreatectomy ; Pancreatic Neoplasms - pathology ; Pancreatic Neoplasms - surgery ; Pancreaticoduodenectomy ; Predictive Value of Tests ; Splenectomy ; Time Factors ; Treatment Outcome ; Tumor Burden ; Watchful Waiting ; Young Adult</subject><ispartof>Pancreas, 2012-04, Vol.41 (3), p.380-387</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-2c0b19cc9e7d8b39adcd5bb53e60ba57be0c0ef370deb07bb83998f9a4ba42f13</citedby><cites>FETCH-LOGICAL-c373t-2c0b19cc9e7d8b39adcd5bb53e60ba57be0c0ef370deb07bb83998f9a4ba42f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22415666$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kimura, Wataru</creatorcontrib><creatorcontrib>Moriya, Toshiyuki</creatorcontrib><creatorcontrib>Hirai, Ichiro</creatorcontrib><creatorcontrib>Hanada, Keiji</creatorcontrib><creatorcontrib>Abe, Hideki</creatorcontrib><creatorcontrib>Yanagisawa, Akio</creatorcontrib><creatorcontrib>Fukushima, Noriyoshi</creatorcontrib><creatorcontrib>Ohike, Nobuyuki</creatorcontrib><creatorcontrib>Shimizu, Michio</creatorcontrib><creatorcontrib>Hatori, Takashi</creatorcontrib><creatorcontrib>Fujita, Naotaka</creatorcontrib><creatorcontrib>Maguchi, Hiroyuki</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><creatorcontrib>Yamao, Kenji</creatorcontrib><creatorcontrib>Sasaki, Tamito</creatorcontrib><creatorcontrib>Naito, Yoshiki</creatorcontrib><creatorcontrib>Tanno, Satoshi</creatorcontrib><creatorcontrib>Tobita, Kosuke</creatorcontrib><creatorcontrib>Tanaka, Masao</creatorcontrib><title>Multicenter study of serous cystic neoplasm of the Japan pancreas society</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) of the pancreas. The frequency of malignancy and surgical indication of SCN are not determined yet.
In this multi-institutional study of the Japan Pancreas Society, a total of 172 patients with SCN were enrolled. The mean follow-up period was 4.5 years. Surgical resection was performed in 90 patients, whereas the remaining 82 were simply observed.
Of all patients, 20% were symptomatic. The tumor was located in the pancreatic head (39%), body (35%), and tail (22%). The mean diameter of the tumor was 4.1 cm. None of the patients showed distant or lymph node metastasis except for liver metastasis found in 2 patients (1.2%). No patient died during the follow-up. The preoperative diagnosis did not correctly identify SCN in 57 (63%) of 90 resected cases. A honeycomb appearance, which is one of the most characteristic findings of SCN, could be diagnosed better by endoscopic ultrasonography than by other imaging diagnostic modalities.
Surgical resection should be considered only when clear distinction from other surgical diseases is difficult, when symptoms or mass effects are present, and when the tumor size is large.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cystadenoma, Mucinous - secondary</subject><subject>Cystadenoma, Mucinous - surgery</subject><subject>Cystadenoma, Serous - secondary</subject><subject>Cystadenoma, Serous - surgery</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Imaging</subject><subject>Female</subject><subject>Humans</subject><subject>Japan</subject><subject>Liver Neoplasms - secondary</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pancreatectomy</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pancreaticoduodenectomy</subject><subject>Predictive Value of Tests</subject><subject>Splenectomy</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Tumor Burden</subject><subject>Watchful Waiting</subject><subject>Young Adult</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkD9PwzAQxS0EoqXwDRDyyJJytuPYHivEn6JWMMAc2c5FBCVNsJMh355ULQwMpxvee3dPP0KuGSwZGHW3fVstwQETKJjm3HJVuBMyZ1JkSaq5PiVz0Fomgik1IxcxfgEwJaQ5JzPOUyazLJuT9Xao-8rjrsdAYz8UI21LGjG0Q6R-jJNGd9h2tY3NXuk_kb7Yzu7oND6gjTS2vsJ-vCRnpa0jXh33gnw8PrzfPyeb16f1_WqTeKFEn3APjhnvDapCO2Fs4QvpnBSYgbNSOQQPWAoFBTpQzmlhjC6NTZ1NecnEgtwe7nah_R4w9nlTRY91baeeQ8wZAFcmhVRN1vRg9aGNMWCZd6FqbBgnU76HmE8Q8_8Qp9jN8cPgGiz-Qr_UxA-mB3AK</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Kimura, Wataru</creator><creator>Moriya, Toshiyuki</creator><creator>Hirai, Ichiro</creator><creator>Hanada, Keiji</creator><creator>Abe, Hideki</creator><creator>Yanagisawa, Akio</creator><creator>Fukushima, Noriyoshi</creator><creator>Ohike, Nobuyuki</creator><creator>Shimizu, Michio</creator><creator>Hatori, Takashi</creator><creator>Fujita, Naotaka</creator><creator>Maguchi, Hiroyuki</creator><creator>Shimizu, Yasuhiro</creator><creator>Yamao, Kenji</creator><creator>Sasaki, Tamito</creator><creator>Naito, Yoshiki</creator><creator>Tanno, Satoshi</creator><creator>Tobita, Kosuke</creator><creator>Tanaka, Masao</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201204</creationdate><title>Multicenter study of serous cystic neoplasm of the Japan pancreas society</title><author>Kimura, Wataru ; Moriya, Toshiyuki ; Hirai, Ichiro ; Hanada, Keiji ; Abe, Hideki ; Yanagisawa, Akio ; Fukushima, Noriyoshi ; Ohike, Nobuyuki ; Shimizu, Michio ; Hatori, Takashi ; Fujita, Naotaka ; Maguchi, Hiroyuki ; Shimizu, Yasuhiro ; Yamao, Kenji ; Sasaki, Tamito ; Naito, Yoshiki ; Tanno, Satoshi ; Tobita, Kosuke ; Tanaka, Masao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-2c0b19cc9e7d8b39adcd5bb53e60ba57be0c0ef370deb07bb83998f9a4ba42f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cystadenoma, Mucinous - secondary</topic><topic>Cystadenoma, Mucinous - surgery</topic><topic>Cystadenoma, Serous - secondary</topic><topic>Cystadenoma, Serous - surgery</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic Imaging</topic><topic>Female</topic><topic>Humans</topic><topic>Japan</topic><topic>Liver Neoplasms - secondary</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pancreatectomy</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pancreaticoduodenectomy</topic><topic>Predictive Value of Tests</topic><topic>Splenectomy</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Tumor Burden</topic><topic>Watchful Waiting</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kimura, Wataru</creatorcontrib><creatorcontrib>Moriya, Toshiyuki</creatorcontrib><creatorcontrib>Hirai, Ichiro</creatorcontrib><creatorcontrib>Hanada, Keiji</creatorcontrib><creatorcontrib>Abe, Hideki</creatorcontrib><creatorcontrib>Yanagisawa, Akio</creatorcontrib><creatorcontrib>Fukushima, Noriyoshi</creatorcontrib><creatorcontrib>Ohike, Nobuyuki</creatorcontrib><creatorcontrib>Shimizu, Michio</creatorcontrib><creatorcontrib>Hatori, Takashi</creatorcontrib><creatorcontrib>Fujita, Naotaka</creatorcontrib><creatorcontrib>Maguchi, Hiroyuki</creatorcontrib><creatorcontrib>Shimizu, Yasuhiro</creatorcontrib><creatorcontrib>Yamao, Kenji</creatorcontrib><creatorcontrib>Sasaki, Tamito</creatorcontrib><creatorcontrib>Naito, Yoshiki</creatorcontrib><creatorcontrib>Tanno, Satoshi</creatorcontrib><creatorcontrib>Tobita, Kosuke</creatorcontrib><creatorcontrib>Tanaka, Masao</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kimura, Wataru</au><au>Moriya, Toshiyuki</au><au>Hirai, Ichiro</au><au>Hanada, Keiji</au><au>Abe, Hideki</au><au>Yanagisawa, Akio</au><au>Fukushima, Noriyoshi</au><au>Ohike, Nobuyuki</au><au>Shimizu, Michio</au><au>Hatori, Takashi</au><au>Fujita, Naotaka</au><au>Maguchi, Hiroyuki</au><au>Shimizu, Yasuhiro</au><au>Yamao, Kenji</au><au>Sasaki, Tamito</au><au>Naito, Yoshiki</au><au>Tanno, Satoshi</au><au>Tobita, Kosuke</au><au>Tanaka, Masao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multicenter study of serous cystic neoplasm of the Japan pancreas society</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>2012-04</date><risdate>2012</risdate><volume>41</volume><issue>3</issue><spage>380</spage><epage>387</epage><pages>380-387</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><abstract>There have been only a few reports on follow-up results of serous cystic neoplasm (SCN) of the pancreas. The frequency of malignancy and surgical indication of SCN are not determined yet.
In this multi-institutional study of the Japan Pancreas Society, a total of 172 patients with SCN were enrolled. The mean follow-up period was 4.5 years. Surgical resection was performed in 90 patients, whereas the remaining 82 were simply observed.
Of all patients, 20% were symptomatic. The tumor was located in the pancreatic head (39%), body (35%), and tail (22%). The mean diameter of the tumor was 4.1 cm. None of the patients showed distant or lymph node metastasis except for liver metastasis found in 2 patients (1.2%). No patient died during the follow-up. The preoperative diagnosis did not correctly identify SCN in 57 (63%) of 90 resected cases. A honeycomb appearance, which is one of the most characteristic findings of SCN, could be diagnosed better by endoscopic ultrasonography than by other imaging diagnostic modalities.
Surgical resection should be considered only when clear distinction from other surgical diseases is difficult, when symptoms or mass effects are present, and when the tumor size is large.</abstract><cop>United States</cop><pmid>22415666</pmid><doi>10.1097/MPA.0b013e31822a27db</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Cystadenoma, Mucinous - secondary Cystadenoma, Mucinous - surgery Cystadenoma, Serous - secondary Cystadenoma, Serous - surgery Diagnosis, Differential Diagnostic Imaging Female Humans Japan Liver Neoplasms - secondary Male Middle Aged Pancreatectomy Pancreatic Neoplasms - pathology Pancreatic Neoplasms - surgery Pancreaticoduodenectomy Predictive Value of Tests Splenectomy Time Factors Treatment Outcome Tumor Burden Watchful Waiting Young Adult |
| title | Multicenter study of serous cystic neoplasm of the Japan pancreas society |
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