Fibrodysplasia induced in dog skin by a matrix metalloproteinase (MMP) inhibitor--a mechanistic analysis

Matrix metalloproteinase (MMP) inhibitors, candidate therapeutic agents for a number of diseases, are known to be associated with acute fibrosis-type adverse effects in a number of species, including humans. The broad-spectrum MMP inhibitor, AZM551248, has previously been shown to cause these effect...

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Veröffentlicht in:	Toxicological sciences 2012-05, Vol.127 (1), p.236-245
Hauptverfasser:	Tugwood, Jonathan D, Kelsall, Janet, Coverley, Lucy C, Westwood, F Russell, Haque, Kemal, Huby, Russell D J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Collagen - metabolism Connective Tissue - drug effects Connective Tissue - pathology Disease Models, Animal Dogs Extracellular Matrix - drug effects Extracellular Matrix - metabolism Female Fibrosis - chemically induced Fibrosis - metabolism Fibrosis - pathology Gene Expression - drug effects Gene Expression Profiling Genome-Wide Association Study Matrix Metalloproteinase Inhibitors Matrix Metalloproteinases - genetics Matrix Metalloproteinases - metabolism Oligonucleotide Array Sequence Analysis Piperazines - toxicity Protease Inhibitors - toxicity Real-Time Polymerase Chain Reaction Skin - drug effects Skin - pathology
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