Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes
Background The atrial natriuretic peptide (ANP) is known mainly for its effects on kidney function and blood pressure homeostasis. We investigated the association between two ANP polymorphisms and pre-existing coronary artery disease (CAD) in patients of African descent with type 2 diabetes (T2D). M...
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| Veröffentlicht in: | American journal of hypertension 2012-05, Vol.25 (5), p.524-527 |
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| creator | Larifla, Laurent Maimaitiming, Suriya Velayoudom-Cephise, Fritz-Line Ferdinand, Severine Blanchet-Deverly, Anne BenAbdallah, Sonia Donnet, Jean-Paul Atallah, André Roussel, Ronan Foucan, Lydia |
| description | Background
The atrial natriuretic peptide (ANP) is known mainly for its effects on kidney function and blood pressure homeostasis. We investigated the association between two ANP polymorphisms and pre-existing coronary artery disease (CAD) in patients of African descent with type 2 diabetes (T2D).
Methods
We conducted a cross-sectional and retrospective study of 218 volunteer Afro-Caribbean patients with T2D. Two polymorphisms (rs5064, 708C>T; and rs5065, 2238T>C) of ANP were genotyped using PCR-restriction fragment length polymorphism analysis. ANCOVA, χ2-test, and logistic regression were used for statistical analysis.
Results
Among these patients (92 men; 128 women), 67 (30.7%) had CAD, of whom 75% had had myocardial infarction. The frequency of rs5065-C carriers (TC/CC) was significantly lower in patients with CAD than in those without CAD (24 vs. 41%, P = 0.01). The frequency of hypertension did not differ significantly according to genotype. Univariate logistic regression revealed that male sex, age, dyslipidemia, hypertension, and rs5065-C carrier status were associated significantly with CAD. After adjustment for the variables of interest, the odds ratio (ORs) of CAD for rs5065-C carriers (TC/CC) was 0.50 (0.26-0.96; P = 0.038). No association was found between the rs5064 (708C>T) single-nucleotide polymorphisms (SNPs) and pre-existing CAD or cardiovascular risk factors.
Conclusions
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent. The relevance of ANP polymorphisms for CAD should be determined in different populations. |
| doi_str_mv | 10.1038/ajh.2011.233 |
| format | Article |
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The atrial natriuretic peptide (ANP) is known mainly for its effects on kidney function and blood pressure homeostasis. We investigated the association between two ANP polymorphisms and pre-existing coronary artery disease (CAD) in patients of African descent with type 2 diabetes (T2D).
Methods
We conducted a cross-sectional and retrospective study of 218 volunteer Afro-Caribbean patients with T2D. Two polymorphisms (rs5064, 708C>T; and rs5065, 2238T>C) of ANP were genotyped using PCR-restriction fragment length polymorphism analysis. ANCOVA, χ2-test, and logistic regression were used for statistical analysis.
Results
Among these patients (92 men; 128 women), 67 (30.7%) had CAD, of whom 75% had had myocardial infarction. The frequency of rs5065-C carriers (TC/CC) was significantly lower in patients with CAD than in those without CAD (24 vs. 41%, P = 0.01). The frequency of hypertension did not differ significantly according to genotype. Univariate logistic regression revealed that male sex, age, dyslipidemia, hypertension, and rs5065-C carrier status were associated significantly with CAD. After adjustment for the variables of interest, the odds ratio (ORs) of CAD for rs5065-C carriers (TC/CC) was 0.50 (0.26-0.96; P = 0.038). No association was found between the rs5064 (708C>T) single-nucleotide polymorphisms (SNPs) and pre-existing CAD or cardiovascular risk factors.
Conclusions
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent. The relevance of ANP polymorphisms for CAD should be determined in different populations.</description><identifier>ISSN: 0895-7061</identifier><identifier>EISSN: 1941-7225</identifier><identifier>EISSN: 1879-1905</identifier><identifier>DOI: 10.1038/ajh.2011.233</identifier><identifier>PMID: 22170009</identifier><identifier>CODEN: AJHYE6</identifier><language>eng</language><publisher>Basingstoke: Oxford University Press</publisher><subject>African Continental Ancestry Group - ethnology ; African Continental Ancestry Group - genetics ; Aged ; Arterial hypertension. Arterial hypotension ; Atrial Natriuretic Factor - genetics ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Comorbidity ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - ethnology ; Coronary Artery Disease - genetics ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - ethnology ; Diabetes Mellitus, Type 2 - genetics ; Female ; Genotype ; Humans ; Male ; Medical sciences ; Middle Aged ; Polymorphism, Single Nucleotide - genetics ; Regression Analysis ; Retrospective Studies ; Risk Factors ; West Indies</subject><ispartof>American journal of hypertension, 2012-05, Vol.25 (5), p.524-527</ispartof><rights>American Journal of Hypertension, Ltd. © 2012 by the American Journal of Hypertension, Ltd. 2012</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Nature Publishing Group May 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-f241d92448076cd73615d8b7299ea8087a012a0b60bf7cb784e28479da22da783</citedby><cites>FETCH-LOGICAL-c349t-f241d92448076cd73615d8b7299ea8087a012a0b60bf7cb784e28479da22da783</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25840107$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22170009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Larifla, Laurent</creatorcontrib><creatorcontrib>Maimaitiming, Suriya</creatorcontrib><creatorcontrib>Velayoudom-Cephise, Fritz-Line</creatorcontrib><creatorcontrib>Ferdinand, Severine</creatorcontrib><creatorcontrib>Blanchet-Deverly, Anne</creatorcontrib><creatorcontrib>BenAbdallah, Sonia</creatorcontrib><creatorcontrib>Donnet, Jean-Paul</creatorcontrib><creatorcontrib>Atallah, André</creatorcontrib><creatorcontrib>Roussel, Ronan</creatorcontrib><creatorcontrib>Foucan, Lydia</creatorcontrib><title>Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes</title><title>American journal of hypertension</title><addtitle>Am J Hypertens</addtitle><description>Background
The atrial natriuretic peptide (ANP) is known mainly for its effects on kidney function and blood pressure homeostasis. We investigated the association between two ANP polymorphisms and pre-existing coronary artery disease (CAD) in patients of African descent with type 2 diabetes (T2D).
Methods
We conducted a cross-sectional and retrospective study of 218 volunteer Afro-Caribbean patients with T2D. Two polymorphisms (rs5064, 708C>T; and rs5065, 2238T>C) of ANP were genotyped using PCR-restriction fragment length polymorphism analysis. ANCOVA, χ2-test, and logistic regression were used for statistical analysis.
Results
Among these patients (92 men; 128 women), 67 (30.7%) had CAD, of whom 75% had had myocardial infarction. The frequency of rs5065-C carriers (TC/CC) was significantly lower in patients with CAD than in those without CAD (24 vs. 41%, P = 0.01). The frequency of hypertension did not differ significantly according to genotype. Univariate logistic regression revealed that male sex, age, dyslipidemia, hypertension, and rs5065-C carrier status were associated significantly with CAD. After adjustment for the variables of interest, the odds ratio (ORs) of CAD for rs5065-C carriers (TC/CC) was 0.50 (0.26-0.96; P = 0.038). No association was found between the rs5064 (708C>T) single-nucleotide polymorphisms (SNPs) and pre-existing CAD or cardiovascular risk factors.
Conclusions
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent. The relevance of ANP polymorphisms for CAD should be determined in different populations.</description><subject>African Continental Ancestry Group - ethnology</subject><subject>African Continental Ancestry Group - genetics</subject><subject>Aged</subject><subject>Arterial hypertension. Arterial hypotension</subject><subject>Atrial Natriuretic Factor - genetics</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</subject><subject>Comorbidity</subject><subject>Coronary Artery Disease - epidemiology</subject><subject>Coronary Artery Disease - ethnology</subject><subject>Coronary Artery Disease - genetics</subject><subject>Cross-Sectional Studies</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetes Mellitus, Type 2 - ethnology</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Female</subject><subject>Genotype</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Polymorphism, Single Nucleotide - genetics</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>West Indies</subject><issn>0895-7061</issn><issn>1941-7225</issn><issn>1879-1905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp90UGL1DAUB_Agijuu3jxLQEQPdkzStEkvQqm6CovuYcRjeU1fmQxt003Sw3wKv7IZZlTw4OlPwo_3Qv6EPOdsy1mu38FhvxWM863I8wdkwyvJMyVE8ZBsmK6KTLGSX5EnIRwYY7Is-WNyJQRX6VRtyM86BGcsROtm6gYqRK537xt658bj5Pyyt2E63cc90jp6CyP9CilXj9EaeodLtD3SG5yR_rBxTxvn3Qz-SGsfMcUHGxACUjvTevAua8DbrkOYw9nvjgtSkRh0GDE8JY8GGAM-u-Q1-f7p4675nN1-u_nS1LeZyWUVs0FI3ldCSs1UaXqVl7zodadEVSFophUwLoB1JesGZTqlJQotVdWDED0onV-TN-e5i3f3K4bYTjYYHEeY0a2h5YyJgulC5Ym-_Ice3Orn9LqT4oznUpVJvT0r410IHod28XZKH5FQeyqqTUW1p6LaVFTiLy5D127C_g_-3UwCry4AgoFx8DAbG_66Qsu0WyX3-uzcuvx_5S9wKKWF</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Larifla, Laurent</creator><creator>Maimaitiming, Suriya</creator><creator>Velayoudom-Cephise, Fritz-Line</creator><creator>Ferdinand, Severine</creator><creator>Blanchet-Deverly, Anne</creator><creator>BenAbdallah, Sonia</creator><creator>Donnet, Jean-Paul</creator><creator>Atallah, André</creator><creator>Roussel, Ronan</creator><creator>Foucan, Lydia</creator><general>Oxford University Press</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes</title><author>Larifla, Laurent ; Maimaitiming, Suriya ; Velayoudom-Cephise, Fritz-Line ; Ferdinand, Severine ; Blanchet-Deverly, Anne ; BenAbdallah, Sonia ; Donnet, Jean-Paul ; Atallah, André ; Roussel, Ronan ; Foucan, Lydia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-f241d92448076cd73615d8b7299ea8087a012a0b60bf7cb784e28479da22da783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>African Continental Ancestry Group - ethnology</topic><topic>African Continental Ancestry Group - genetics</topic><topic>Aged</topic><topic>Arterial hypertension. Arterial hypotension</topic><topic>Atrial Natriuretic Factor - genetics</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Clinical manifestations. Epidemiology. Investigative techniques. Etiology</topic><topic>Comorbidity</topic><topic>Coronary Artery Disease - epidemiology</topic><topic>Coronary Artery Disease - ethnology</topic><topic>Coronary Artery Disease - genetics</topic><topic>Cross-Sectional Studies</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetes Mellitus, Type 2 - ethnology</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Female</topic><topic>Genotype</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Polymorphism, Single Nucleotide - genetics</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>West Indies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Larifla, Laurent</creatorcontrib><creatorcontrib>Maimaitiming, Suriya</creatorcontrib><creatorcontrib>Velayoudom-Cephise, Fritz-Line</creatorcontrib><creatorcontrib>Ferdinand, Severine</creatorcontrib><creatorcontrib>Blanchet-Deverly, Anne</creatorcontrib><creatorcontrib>BenAbdallah, Sonia</creatorcontrib><creatorcontrib>Donnet, Jean-Paul</creatorcontrib><creatorcontrib>Atallah, André</creatorcontrib><creatorcontrib>Roussel, Ronan</creatorcontrib><creatorcontrib>Foucan, Lydia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hypertension</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Larifla, Laurent</au><au>Maimaitiming, Suriya</au><au>Velayoudom-Cephise, Fritz-Line</au><au>Ferdinand, Severine</au><au>Blanchet-Deverly, Anne</au><au>BenAbdallah, Sonia</au><au>Donnet, Jean-Paul</au><au>Atallah, André</au><au>Roussel, Ronan</au><au>Foucan, Lydia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes</atitle><jtitle>American journal of hypertension</jtitle><addtitle>Am J Hypertens</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>25</volume><issue>5</issue><spage>524</spage><epage>527</epage><pages>524-527</pages><issn>0895-7061</issn><eissn>1941-7225</eissn><eissn>1879-1905</eissn><coden>AJHYE6</coden><abstract>Background
The atrial natriuretic peptide (ANP) is known mainly for its effects on kidney function and blood pressure homeostasis. We investigated the association between two ANP polymorphisms and pre-existing coronary artery disease (CAD) in patients of African descent with type 2 diabetes (T2D).
Methods
We conducted a cross-sectional and retrospective study of 218 volunteer Afro-Caribbean patients with T2D. Two polymorphisms (rs5064, 708C>T; and rs5065, 2238T>C) of ANP were genotyped using PCR-restriction fragment length polymorphism analysis. ANCOVA, χ2-test, and logistic regression were used for statistical analysis.
Results
Among these patients (92 men; 128 women), 67 (30.7%) had CAD, of whom 75% had had myocardial infarction. The frequency of rs5065-C carriers (TC/CC) was significantly lower in patients with CAD than in those without CAD (24 vs. 41%, P = 0.01). The frequency of hypertension did not differ significantly according to genotype. Univariate logistic regression revealed that male sex, age, dyslipidemia, hypertension, and rs5065-C carrier status were associated significantly with CAD. After adjustment for the variables of interest, the odds ratio (ORs) of CAD for rs5065-C carriers (TC/CC) was 0.50 (0.26-0.96; P = 0.038). No association was found between the rs5064 (708C>T) single-nucleotide polymorphisms (SNPs) and pre-existing CAD or cardiovascular risk factors.
Conclusions
The ANP rs5065 (2238T>C) C allele seems to exert a protective effect against CAD in T2D patients of African descent. The relevance of ANP polymorphisms for CAD should be determined in different populations.</abstract><cop>Basingstoke</cop><pub>Oxford University Press</pub><pmid>22170009</pmid><doi>10.1038/ajh.2011.233</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | American journal of hypertension, 2012-05, Vol.25 (5), p.524-527 |
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| subjects | African Continental Ancestry Group - ethnology African Continental Ancestry Group - genetics Aged Arterial hypertension. Arterial hypotension Atrial Natriuretic Factor - genetics Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - epidemiology Clinical manifestations. Epidemiology. Investigative techniques. Etiology Comorbidity Coronary Artery Disease - epidemiology Coronary Artery Disease - ethnology Coronary Artery Disease - genetics Cross-Sectional Studies Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics Female Genotype Humans Male Medical sciences Middle Aged Polymorphism, Single Nucleotide - genetics Regression Analysis Retrospective Studies Risk Factors West Indies |
| title | Association of 2238T>C Polymorphism of the Atrial Natriuretic Peptide Gene With Coronary Artery Disease in Afro-Caribbeans With Type 2 Diabetes |
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