Glucagon-like peptide-1 receptor agonism improves metabolic, biochemical, and histopathological indices of nonalcoholic steatohepatitis in mice

These preclinical studies aimed to 1) increase our understanding the dietary induction of nonalcoholic steatohepatitis (NASH), and, 2) further explore the utility and mechanisms of glucagon-like peptide-1 receptor (GLP-1R) agonism in NASH. We compared the effects of a high trans-fat (HTF) or high la...

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Veröffentlicht in:	American journal of physiology: Gastrointestinal and liver physiology 2012-04, Vol.302 (8), p.G762-G772
Hauptverfasser:	Trevaskis, James L, Griffin, Peter S, Wittmer, Carrie, Neuschwander-Tetri, Brent A, Brunt, Elizabeth M, Dolman, Carrie S, Erickson, Mary R, Napora, James, Parkes, David G, Roth, Jonathan D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Body Composition - physiology Body Weight - drug effects Diet Diet, Fat-Restricted Diet, High-Fat Endpoint Determination Fatty Liver - chemically induced Fatty Liver - drug therapy Fatty Liver - metabolism Fatty Liver - pathology Gene Expression - drug effects Glucagon-Like Peptide-1 Receptor Hormones - blood Leptin - genetics Lipids - chemistry Liver - metabolism Liver - pathology Liver diseases Liver Function Tests Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Obese Non-alcoholic Fatty Liver Disease Peptides Peptides - therapeutic use Receptors, Glucagon - agonists Receptors, Glucagon - genetics Rodents T cell receptors Trans Fatty Acids - pharmacology Weight Loss - drug effects
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