σ-1 Receptor Agonist SKF10047 Inhibits Glutamate Release in Rat Cerebral Cortex Nerve Endings

σ-1 Receptors are expressed in the brain, and their activation has been shown to prevent neuronal death associated with glutamate toxicity. This study investigates the possible mechanism and effect of [2S-(2α,6α,11R*]-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol (...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2012-05, Vol.341 (2), p.532-542
Hauptverfasser:	Lu, Cheng-Wei, Lin, Tzu-Yu, Wang, Chia-Chuan, Wang, Su-Jane
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aminopyridine - pharmacology Amino Acid Transport System X-AG - antagonists & inhibitors Animals Aspartic Acid - pharmacology Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels - metabolism Calcium Channels, N-Type - metabolism Cerebral Cortex - drug effects Cerebral Cortex - metabolism Cytosol - drug effects Cytosol - metabolism Glutamic Acid - metabolism Macrolides - pharmacology Male Membrane Potentials - drug effects Mitochondria - drug effects Mitochondria - metabolism Nerve Endings - drug effects Nerve Endings - metabolism Phenazocine - analogs & derivatives Phenazocine - pharmacology Phosphorylation - drug effects Potassium Channel Blockers - pharmacology Potassium Channels - metabolism Protein Kinase C - antagonists & inhibitors Rats Rats, Sprague-Dawley Receptors, sigma - agonists Receptors, sigma - metabolism Ryanodine Receptor Calcium Release Channel - metabolism Sigma-1 Receptor Sodium-Calcium Exchanger - metabolism Vesicular Transport Proteins - antagonists & inhibitors Vesicular Transport Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!