Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats
Terminalia pallida is an evergreen endemic tree, mentioned in Ayurveda as the fruits of Terminalia pallida are excellent in cardioprotective property. Tribal people use Terminalia pallida fruit for the treatment of diabetes and this plant widely used in many other disorders. The present investigatio...
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| Veröffentlicht in: | Journal of ethnopharmacology 2012-05, Vol.141 (1), p.33-40 |
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| creator | Shaik, Althaf Hussain Rasool, S.N. Vikram Kumar Reddy, A. Abdul Kareem, M. Saayi Krushna, G. Lakshmi Devi, K. |
| description | Terminalia pallida is an evergreen endemic tree, mentioned in Ayurveda as the fruits of Terminalia pallida are excellent in cardioprotective property. Tribal people use Terminalia pallida fruit for the treatment of diabetes and this plant widely used in many other disorders.
The present investigation was to evaluate the antioxidant, biochemical profile and histological studies of qualitatively standardized ethanolic extract of Terminalia pallida fruits (TpFE) against isoproterenol-induced myocardial infarction in rats.
TpFE was standardized by high performance liquid chromatography (HPLC) and mass spectroscopy (MS). Rats were pretreated orally with different doses of TpFE (100, 300, and 500mgkg−1 body weight) and cardioprotective positive control gallic acid (GA) for 30 days prior to isoproterenol (ISO) induced myocardial infarction. The rats were sacrificed, hearts were collected and homogenized for biochemical analysis. The effects on total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), lipid peroxidation (LPO) marker, malondialdehyde (MDA), creatine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate transaminase (AST), catalase (CAT), glutathione peroxidase (GPx), sodium potassium (Na+/K+), calcium (Ca2+) and magnesium (Mg2+) adenosine triphosphatases (ATPases) were estimated in heart tissue homogenate.
Rats administered with ISO showed a significant increase in TC, TG, LDL-C, VLDL-C, and MDA and a significant decrease in HDL-C, cardiac marker enzymes – CK, LDH, ALT and AST. ISO significantly reduced antioxidants – CAT, GPx, and membrane bound enzymes – Na+/K+, Ca2+ and Mg2+ ATPases. Pretreatment with TpFE (100, 300, and 500mgkg−1 bw) and GA (15mgkg−1 bw) for a period of 30 days significantly inhibited the effects of ISO. Moreover, biochemical findings were supported by histopathological observations.
The present study provide evidence for the first time, that TpFE pretreatment ameliorated myocardial injury in ISO-induced myocardial infarcted rats and exhibited cardioprotective activity. |
| doi_str_mv | 10.1016/j.jep.2012.01.011 |
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The present investigation was to evaluate the antioxidant, biochemical profile and histological studies of qualitatively standardized ethanolic extract of Terminalia pallida fruits (TpFE) against isoproterenol-induced myocardial infarction in rats.
TpFE was standardized by high performance liquid chromatography (HPLC) and mass spectroscopy (MS). Rats were pretreated orally with different doses of TpFE (100, 300, and 500mgkg−1 body weight) and cardioprotective positive control gallic acid (GA) for 30 days prior to isoproterenol (ISO) induced myocardial infarction. The rats were sacrificed, hearts were collected and homogenized for biochemical analysis. The effects on total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), lipid peroxidation (LPO) marker, malondialdehyde (MDA), creatine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate transaminase (AST), catalase (CAT), glutathione peroxidase (GPx), sodium potassium (Na+/K+), calcium (Ca2+) and magnesium (Mg2+) adenosine triphosphatases (ATPases) were estimated in heart tissue homogenate.
Rats administered with ISO showed a significant increase in TC, TG, LDL-C, VLDL-C, and MDA and a significant decrease in HDL-C, cardiac marker enzymes – CK, LDH, ALT and AST. ISO significantly reduced antioxidants – CAT, GPx, and membrane bound enzymes – Na+/K+, Ca2+ and Mg2+ ATPases. Pretreatment with TpFE (100, 300, and 500mgkg−1 bw) and GA (15mgkg−1 bw) for a period of 30 days significantly inhibited the effects of ISO. Moreover, biochemical findings were supported by histopathological observations.
The present study provide evidence for the first time, that TpFE pretreatment ameliorated myocardial injury in ISO-induced myocardial infarcted rats and exhibited cardioprotective activity.</description><identifier>ISSN: 0378-8741</identifier><identifier>EISSN: 1872-7573</identifier><identifier>DOI: 10.1016/j.jep.2012.01.011</identifier><identifier>PMID: 22366678</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adenosine Triphosphatases - metabolism ; Animals ; Antioxidant enzymes ; Antioxidants - metabolism ; ATPases ; Biomarkers - metabolism ; Cardiovascular Agents - chemistry ; Cardiovascular Agents - isolation & purification ; Cardiovascular Agents - pharmacology ; Cardiovascular Agents - standards ; Chromatography, High Pressure Liquid ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Ethanol - chemistry ; Fruit ; HPLC ; Isoproterenol ; Lipid Peroxidation - drug effects ; Lipid profile ; Lipids - blood ; Male ; Myocardial infarction ; Myocardial Infarction - blood ; Myocardial Infarction - chemically induced ; Myocardial Infarction - pathology ; Myocardial Infarction - prevention & control ; Myocardium - metabolism ; Myocardium - pathology ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - standards ; Plants, Medicinal ; Protective Agents - chemistry ; Protective Agents - isolation & purification ; Protective Agents - pharmacology ; Protective Agents - standards ; Rats ; Rats, Wistar ; Solvents - chemistry ; Spectrometry, Mass, Electrospray Ionization ; Terminalia - chemistry ; Terminalia pallida fruits ; Time Factors</subject><ispartof>Journal of ethnopharmacology, 2012-05, Vol.141 (1), p.33-40</ispartof><rights>2012 Elsevier Ireland Ltd</rights><rights>Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-feac34323206b3572daceda6eedbb8aa46c588bb646f150e62a95d9bdb89566b3</citedby><cites>FETCH-LOGICAL-c353t-feac34323206b3572daceda6eedbb8aa46c588bb646f150e62a95d9bdb89566b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378874112000244$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22366678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shaik, Althaf Hussain</creatorcontrib><creatorcontrib>Rasool, S.N.</creatorcontrib><creatorcontrib>Vikram Kumar Reddy, A.</creatorcontrib><creatorcontrib>Abdul Kareem, M.</creatorcontrib><creatorcontrib>Saayi Krushna, G.</creatorcontrib><creatorcontrib>Lakshmi Devi, K.</creatorcontrib><title>Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats</title><title>Journal of ethnopharmacology</title><addtitle>J Ethnopharmacol</addtitle><description>Terminalia pallida is an evergreen endemic tree, mentioned in Ayurveda as the fruits of Terminalia pallida are excellent in cardioprotective property. Tribal people use Terminalia pallida fruit for the treatment of diabetes and this plant widely used in many other disorders.
The present investigation was to evaluate the antioxidant, biochemical profile and histological studies of qualitatively standardized ethanolic extract of Terminalia pallida fruits (TpFE) against isoproterenol-induced myocardial infarction in rats.
TpFE was standardized by high performance liquid chromatography (HPLC) and mass spectroscopy (MS). Rats were pretreated orally with different doses of TpFE (100, 300, and 500mgkg−1 body weight) and cardioprotective positive control gallic acid (GA) for 30 days prior to isoproterenol (ISO) induced myocardial infarction. The rats were sacrificed, hearts were collected and homogenized for biochemical analysis. The effects on total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), lipid peroxidation (LPO) marker, malondialdehyde (MDA), creatine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate transaminase (AST), catalase (CAT), glutathione peroxidase (GPx), sodium potassium (Na+/K+), calcium (Ca2+) and magnesium (Mg2+) adenosine triphosphatases (ATPases) were estimated in heart tissue homogenate.
Rats administered with ISO showed a significant increase in TC, TG, LDL-C, VLDL-C, and MDA and a significant decrease in HDL-C, cardiac marker enzymes – CK, LDH, ALT and AST. ISO significantly reduced antioxidants – CAT, GPx, and membrane bound enzymes – Na+/K+, Ca2+ and Mg2+ ATPases. Pretreatment with TpFE (100, 300, and 500mgkg−1 bw) and GA (15mgkg−1 bw) for a period of 30 days significantly inhibited the effects of ISO. Moreover, biochemical findings were supported by histopathological observations.
The present study provide evidence for the first time, that TpFE pretreatment ameliorated myocardial injury in ISO-induced myocardial infarcted rats and exhibited cardioprotective activity.</description><subject>Adenosine Triphosphatases - metabolism</subject><subject>Animals</subject><subject>Antioxidant enzymes</subject><subject>Antioxidants - metabolism</subject><subject>ATPases</subject><subject>Biomarkers - metabolism</subject><subject>Cardiovascular Agents - chemistry</subject><subject>Cardiovascular Agents - isolation & purification</subject><subject>Cardiovascular Agents - pharmacology</subject><subject>Cardiovascular Agents - standards</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Ethanol - chemistry</subject><subject>Fruit</subject><subject>HPLC</subject><subject>Isoproterenol</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipid profile</subject><subject>Lipids - blood</subject><subject>Male</subject><subject>Myocardial infarction</subject><subject>Myocardial Infarction - blood</subject><subject>Myocardial Infarction - chemically induced</subject><subject>Myocardial Infarction - pathology</subject><subject>Myocardial Infarction - prevention & control</subject><subject>Myocardium - metabolism</subject><subject>Myocardium - pathology</subject><subject>Phytotherapy</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - standards</subject><subject>Plants, Medicinal</subject><subject>Protective Agents - chemistry</subject><subject>Protective Agents - isolation & purification</subject><subject>Protective Agents - pharmacology</subject><subject>Protective Agents - standards</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Solvents - chemistry</subject><subject>Spectrometry, Mass, Electrospray Ionization</subject><subject>Terminalia - chemistry</subject><subject>Terminalia pallida fruits</subject><subject>Time Factors</subject><issn>0378-8741</issn><issn>1872-7573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUGPFCEQhYnRuOPqD_BiOHrpEZpuujuezERdk0n0sJ5JAYUy6YYR6I3rj_G3yqRXjyaVUIfvvUflEfKSsz1nXL457U943reMt3vG6_BHZMfHoW2GfhCPyY6JYWzGoeNX5FnOJ8bYwDv2lFy1rZBSDuOO_D5Asj6eUyxoir9Dis7VjUZHb74cDzQXCPbC_EJLsXyHEGdvKP4sCTbsFtPiA8we6Bnm2VugLq2-ZArfwIdcqM9bQMIqbnywq6lmy300F2OYqQ8OUo2Poa4UZu1DpAlKfk6eOJgzvnh4r8nXD-9vDzfN8fPHT4d3x8aIXpTGIRjRiVa0TGrRD62FmgAS0Wo9AnTS9OOoteyk4z1D2cLU20lbPU69rJJr8nrzrf_8sWIuavHZ4DxDwLhmxRnjk-xEP1WUb6hJMeeETp2TXyDdV0hdalEnVWtRl1oU43V41bx6sF_1gvaf4m8PFXi7AViPvPOYVDYeQz3Cp9qGstH_x_4PrFKilA</recordid><startdate>20120507</startdate><enddate>20120507</enddate><creator>Shaik, Althaf Hussain</creator><creator>Rasool, S.N.</creator><creator>Vikram Kumar Reddy, A.</creator><creator>Abdul Kareem, M.</creator><creator>Saayi Krushna, G.</creator><creator>Lakshmi Devi, K.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120507</creationdate><title>Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats</title><author>Shaik, Althaf Hussain ; Rasool, S.N. ; Vikram Kumar Reddy, A. ; Abdul Kareem, M. ; Saayi Krushna, G. ; Lakshmi Devi, K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-feac34323206b3572daceda6eedbb8aa46c588bb646f150e62a95d9bdb89566b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adenosine Triphosphatases - metabolism</topic><topic>Animals</topic><topic>Antioxidant enzymes</topic><topic>Antioxidants - metabolism</topic><topic>ATPases</topic><topic>Biomarkers - metabolism</topic><topic>Cardiovascular Agents - chemistry</topic><topic>Cardiovascular Agents - isolation & purification</topic><topic>Cardiovascular Agents - pharmacology</topic><topic>Cardiovascular Agents - standards</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Disease Models, Animal</topic><topic>Dose-Response Relationship, Drug</topic><topic>Ethanol - chemistry</topic><topic>Fruit</topic><topic>HPLC</topic><topic>Isoproterenol</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipid profile</topic><topic>Lipids - blood</topic><topic>Male</topic><topic>Myocardial infarction</topic><topic>Myocardial Infarction - blood</topic><topic>Myocardial Infarction - chemically induced</topic><topic>Myocardial Infarction - pathology</topic><topic>Myocardial Infarction - prevention & control</topic><topic>Myocardium - metabolism</topic><topic>Myocardium - pathology</topic><topic>Phytotherapy</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - standards</topic><topic>Plants, Medicinal</topic><topic>Protective Agents - chemistry</topic><topic>Protective Agents - isolation & purification</topic><topic>Protective Agents - pharmacology</topic><topic>Protective Agents - standards</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Solvents - chemistry</topic><topic>Spectrometry, Mass, Electrospray Ionization</topic><topic>Terminalia - chemistry</topic><topic>Terminalia pallida fruits</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shaik, Althaf Hussain</creatorcontrib><creatorcontrib>Rasool, S.N.</creatorcontrib><creatorcontrib>Vikram Kumar Reddy, A.</creatorcontrib><creatorcontrib>Abdul Kareem, M.</creatorcontrib><creatorcontrib>Saayi Krushna, G.</creatorcontrib><creatorcontrib>Lakshmi Devi, K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ethnopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shaik, Althaf Hussain</au><au>Rasool, S.N.</au><au>Vikram Kumar Reddy, A.</au><au>Abdul Kareem, M.</au><au>Saayi Krushna, G.</au><au>Lakshmi Devi, K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats</atitle><jtitle>Journal of ethnopharmacology</jtitle><addtitle>J Ethnopharmacol</addtitle><date>2012-05-07</date><risdate>2012</risdate><volume>141</volume><issue>1</issue><spage>33</spage><epage>40</epage><pages>33-40</pages><issn>0378-8741</issn><eissn>1872-7573</eissn><abstract>Terminalia pallida is an evergreen endemic tree, mentioned in Ayurveda as the fruits of Terminalia pallida are excellent in cardioprotective property. Tribal people use Terminalia pallida fruit for the treatment of diabetes and this plant widely used in many other disorders.
The present investigation was to evaluate the antioxidant, biochemical profile and histological studies of qualitatively standardized ethanolic extract of Terminalia pallida fruits (TpFE) against isoproterenol-induced myocardial infarction in rats.
TpFE was standardized by high performance liquid chromatography (HPLC) and mass spectroscopy (MS). Rats were pretreated orally with different doses of TpFE (100, 300, and 500mgkg−1 body weight) and cardioprotective positive control gallic acid (GA) for 30 days prior to isoproterenol (ISO) induced myocardial infarction. The rats were sacrificed, hearts were collected and homogenized for biochemical analysis. The effects on total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C), high density lipoprotein cholesterol (HDL-C), lipid peroxidation (LPO) marker, malondialdehyde (MDA), creatine kinase (CK), lactate dehydrogenase (LDH), alanine transaminase (ALT), aspartate transaminase (AST), catalase (CAT), glutathione peroxidase (GPx), sodium potassium (Na+/K+), calcium (Ca2+) and magnesium (Mg2+) adenosine triphosphatases (ATPases) were estimated in heart tissue homogenate.
Rats administered with ISO showed a significant increase in TC, TG, LDL-C, VLDL-C, and MDA and a significant decrease in HDL-C, cardiac marker enzymes – CK, LDH, ALT and AST. ISO significantly reduced antioxidants – CAT, GPx, and membrane bound enzymes – Na+/K+, Ca2+ and Mg2+ ATPases. Pretreatment with TpFE (100, 300, and 500mgkg−1 bw) and GA (15mgkg−1 bw) for a period of 30 days significantly inhibited the effects of ISO. Moreover, biochemical findings were supported by histopathological observations.
The present study provide evidence for the first time, that TpFE pretreatment ameliorated myocardial injury in ISO-induced myocardial infarcted rats and exhibited cardioprotective activity.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>22366678</pmid><doi>10.1016/j.jep.2012.01.011</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of ethnopharmacology, 2012-05, Vol.141 (1), p.33-40 |
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| subjects | Adenosine Triphosphatases - metabolism Animals Antioxidant enzymes Antioxidants - metabolism ATPases Biomarkers - metabolism Cardiovascular Agents - chemistry Cardiovascular Agents - isolation & purification Cardiovascular Agents - pharmacology Cardiovascular Agents - standards Chromatography, High Pressure Liquid Disease Models, Animal Dose-Response Relationship, Drug Ethanol - chemistry Fruit HPLC Isoproterenol Lipid Peroxidation - drug effects Lipid profile Lipids - blood Male Myocardial infarction Myocardial Infarction - blood Myocardial Infarction - chemically induced Myocardial Infarction - pathology Myocardial Infarction - prevention & control Myocardium - metabolism Myocardium - pathology Phytotherapy Plant Extracts - chemistry Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - standards Plants, Medicinal Protective Agents - chemistry Protective Agents - isolation & purification Protective Agents - pharmacology Protective Agents - standards Rats Rats, Wistar Solvents - chemistry Spectrometry, Mass, Electrospray Ionization Terminalia - chemistry Terminalia pallida fruits Time Factors |
| title | Cardioprotective effect of HPLC standardized ethanolic extract of Terminalia pallida fruits against isoproterenol-induced myocardial infarction in albino rats |
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