Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae
[Display omitted] ► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties. Propolis is derived from plant res...
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| Veröffentlicht in: | Journal of invertebrate pathology 2012-05, Vol.110 (1), p.68-72 |
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| container_title | Journal of invertebrate pathology |
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| creator | Mihai, Cristina Manuela Mărghitaş, Liviu Al Dezmirean, Daniel S. Chirilă, Flore Moritz, Robin F.A. Schlüns, Helge |
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► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties.
Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens. |
| doi_str_mv | 10.1016/j.jip.2012.02.009 |
| format | Article |
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► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties.
Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens.</description><identifier>ISSN: 0022-2011</identifier><identifier>EISSN: 1096-0805</identifier><identifier>DOI: 10.1016/j.jip.2012.02.009</identifier><identifier>PMID: 22386493</identifier><identifier>CODEN: JIVPAZ</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>American foul brood ; American Foulbrood ; Animal productions ; Animals ; Anti-Infective Agents - chemistry ; Anti-Infective Agents - pharmacology ; antibacterial properties ; Apiculture ; Apis mellifera ; Bees - drug effects ; Bees - microbiology ; Biological and medical sciences ; Flavonoids ; Flavonoids - chemistry ; Fundamental and applied biological sciences. Psychology ; honey bee colonies ; honey bees ; Insecta ; Invertebrates ; larvae ; Microbial Sensitivity Tests ; Paenibacillus ; Paenibacillus larvae ; pathogens ; Polyphenols ; Propolis ; Propolis - chemistry ; Propolis - pharmacology ; resins ; Terrestrial animal productions</subject><ispartof>Journal of invertebrate pathology, 2012-05, Vol.110 (1), p.68-72</ispartof><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c407t-dd65f34bf8a29a0ea352ff0dcee91a34126ee5dbbfc54d0740c83961c6615a1d3</citedby><cites>FETCH-LOGICAL-c407t-dd65f34bf8a29a0ea352ff0dcee91a34126ee5dbbfc54d0740c83961c6615a1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jip.2012.02.009$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3552,27931,27932,46002</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25849566$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22386493$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mihai, Cristina Manuela</creatorcontrib><creatorcontrib>Mărghitaş, Liviu Al</creatorcontrib><creatorcontrib>Dezmirean, Daniel S.</creatorcontrib><creatorcontrib>Chirilă, Flore</creatorcontrib><creatorcontrib>Moritz, Robin F.A.</creatorcontrib><creatorcontrib>Schlüns, Helge</creatorcontrib><title>Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae</title><title>Journal of invertebrate pathology</title><addtitle>J Invertebr Pathol</addtitle><description>[Display omitted]
► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties.
Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens.</description><subject>American foul brood</subject><subject>American Foulbrood</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>antibacterial properties</subject><subject>Apiculture</subject><subject>Apis mellifera</subject><subject>Bees - drug effects</subject><subject>Bees - microbiology</subject><subject>Biological and medical sciences</subject><subject>Flavonoids</subject><subject>Flavonoids - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>honey bee colonies</subject><subject>honey bees</subject><subject>Insecta</subject><subject>Invertebrates</subject><subject>larvae</subject><subject>Microbial Sensitivity Tests</subject><subject>Paenibacillus</subject><subject>Paenibacillus larvae</subject><subject>pathogens</subject><subject>Polyphenols</subject><subject>Propolis</subject><subject>Propolis - chemistry</subject><subject>Propolis - pharmacology</subject><subject>resins</subject><subject>Terrestrial animal productions</subject><issn>0022-2011</issn><issn>1096-0805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2LEzEUhoMobnf1B3ijuRH2ZupJZiadwStZ_FhYUNC9DmeSkzZlmozJtFB_vSmteiccSOA870nyhLFXApYChHq3XW79tJQg5BJKQf-ELQT0qoIO2qdsASBlVdriil3nvIWya1X_nF1JWXeq6esF-3UfZkpoZh9D5riLYc3diIcYoreZR8enFKc4-tJ0jszMMcx-KAFKHkd-Sh78fOS4Rh_yzOcN8U0MdByI-ITzJq4p8G9I4ZTy47jPfMR0QHrBnjkcM728rDfs8dPHH3dfqoevn-_vPjxUpoHVXFmrWlc3g-tQ9giEdSudA2uIeoF1I6Qiau0wONM2FlYNmK7ulTBKiRaFrW_Y7XluecnPPeVZ73w2NI4YKO6zFsVL4aUSBRVn1KSYcyKnp-R3mI4F0iflequLcn1SrqEU9CXz-jJ-P-zI_k38cVyAtxcAs8HRJQzG539c2zV9q1Th3pw5h1HjOhXm8Xs5SQFA3cl-VYj3Z4KKroOnpLPxFAxZn8rXaBv9fy76G6IFqs4</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Mihai, Cristina Manuela</creator><creator>Mărghitaş, Liviu Al</creator><creator>Dezmirean, Daniel S.</creator><creator>Chirilă, Flore</creator><creator>Moritz, Robin F.A.</creator><creator>Schlüns, Helge</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae</title><author>Mihai, Cristina Manuela ; Mărghitaş, Liviu Al ; Dezmirean, Daniel S. ; Chirilă, Flore ; Moritz, Robin F.A. ; Schlüns, Helge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-dd65f34bf8a29a0ea352ff0dcee91a34126ee5dbbfc54d0740c83961c6615a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>American foul brood</topic><topic>American Foulbrood</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>antibacterial properties</topic><topic>Apiculture</topic><topic>Apis mellifera</topic><topic>Bees - drug effects</topic><topic>Bees - microbiology</topic><topic>Biological and medical sciences</topic><topic>Flavonoids</topic><topic>Flavonoids - chemistry</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>honey bee colonies</topic><topic>honey bees</topic><topic>Insecta</topic><topic>Invertebrates</topic><topic>larvae</topic><topic>Microbial Sensitivity Tests</topic><topic>Paenibacillus</topic><topic>Paenibacillus larvae</topic><topic>pathogens</topic><topic>Polyphenols</topic><topic>Propolis</topic><topic>Propolis - chemistry</topic><topic>Propolis - pharmacology</topic><topic>resins</topic><topic>Terrestrial animal productions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mihai, Cristina Manuela</creatorcontrib><creatorcontrib>Mărghitaş, Liviu Al</creatorcontrib><creatorcontrib>Dezmirean, Daniel S.</creatorcontrib><creatorcontrib>Chirilă, Flore</creatorcontrib><creatorcontrib>Moritz, Robin F.A.</creatorcontrib><creatorcontrib>Schlüns, Helge</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of invertebrate pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mihai, Cristina Manuela</au><au>Mărghitaş, Liviu Al</au><au>Dezmirean, Daniel S.</au><au>Chirilă, Flore</au><au>Moritz, Robin F.A.</au><au>Schlüns, Helge</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae</atitle><jtitle>Journal of invertebrate pathology</jtitle><addtitle>J Invertebr Pathol</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>110</volume><issue>1</issue><spage>68</spage><epage>72</epage><pages>68-72</pages><issn>0022-2011</issn><eissn>1096-0805</eissn><coden>JIVPAZ</coden><abstract>[Display omitted]
► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties.
Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>22386493</pmid><doi>10.1016/j.jip.2012.02.009</doi><tpages>5</tpages></addata></record> |
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| subjects | American foul brood American Foulbrood Animal productions Animals Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology antibacterial properties Apiculture Apis mellifera Bees - drug effects Bees - microbiology Biological and medical sciences Flavonoids Flavonoids - chemistry Fundamental and applied biological sciences. Psychology honey bee colonies honey bees Insecta Invertebrates larvae Microbial Sensitivity Tests Paenibacillus Paenibacillus larvae pathogens Polyphenols Propolis Propolis - chemistry Propolis - pharmacology resins Terrestrial animal productions |
| title | Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae |
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