Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae

[Display omitted] ► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties. Propolis is derived from plant res...

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Veröffentlicht in:Journal of invertebrate pathology 2012-05, Vol.110 (1), p.68-72
Hauptverfasser: Mihai, Cristina Manuela, Mărghitaş, Liviu Al, Dezmirean, Daniel S., Chirilă, Flore, Moritz, Robin F.A., Schlüns, Helge
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container_end_page 72
container_issue 1
container_start_page 68
container_title Journal of invertebrate pathology
container_volume 110
creator Mihai, Cristina Manuela
Mărghitaş, Liviu Al
Dezmirean, Daniel S.
Chirilă, Flore
Moritz, Robin F.A.
Schlüns, Helge
description [Display omitted] ► Propolis extracts of different origins inhibited the growth of Paenibacillus larvae. ► The extracts showed major differences in the content of flavonoids and polyphenols. ► Interaction effects among flavonoids influence antimicrobial properties. Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens.
doi_str_mv 10.1016/j.jip.2012.02.009
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Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. 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Psychology ; honey bee colonies ; honey bees ; Insecta ; Invertebrates ; larvae ; Microbial Sensitivity Tests ; Paenibacillus ; Paenibacillus larvae ; pathogens ; Polyphenols ; Propolis ; Propolis - chemistry ; Propolis - pharmacology ; resins ; Terrestrial animal productions</subject><ispartof>Journal of invertebrate pathology, 2012-05, Vol.110 (1), p.68-72</ispartof><rights>2012 Elsevier Inc.</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2012 Elsevier Inc. 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Propolis is derived from plant resins, collected by honeybees (Apis mellifera) and renown for its antibacterial properties. Here we test the antibacterial effects of ethanolic extracts of propolis from different origins on Paenibacillus larvae, the bacterial pathogen that causes American Foulbrood, a larval disease that can kill the honeybee colony. All tested propolis samples inhibited significantly the growth of P. larvae tested in vitro. The extracts showed major differences in the content of total flavonoids (ranging from 2.4% to 16.4%) and the total polyphenols (ranging between 23.3% and 63.2%). We found that it is not only the content of compounds in propolis, which influences the strength of antimicrobial effects but there is also a significant interaction effect among flavonoids of the propolis extracts. We propose that interaction effects among the various chemical compounds in propolis should be taken into account when considering the antibacterial effects against honeybee pathogens.</description><subject>American foul brood</subject><subject>American Foulbrood</subject><subject>Animal productions</subject><subject>Animals</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>antibacterial properties</subject><subject>Apiculture</subject><subject>Apis mellifera</subject><subject>Bees - drug effects</subject><subject>Bees - microbiology</subject><subject>Biological and medical sciences</subject><subject>Flavonoids</subject><subject>Flavonoids - chemistry</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>honey bee colonies</subject><subject>honey bees</subject><subject>Insecta</subject><subject>Invertebrates</subject><subject>larvae</subject><subject>Microbial Sensitivity Tests</subject><subject>Paenibacillus</subject><subject>Paenibacillus larvae</subject><subject>pathogens</subject><subject>Polyphenols</subject><subject>Propolis</subject><subject>Propolis - chemistry</subject><subject>Propolis - pharmacology</subject><subject>resins</subject><subject>Terrestrial animal productions</subject><issn>0022-2011</issn><issn>1096-0805</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kV2LEzEUhoMobnf1B3ijuRH2ZupJZiadwStZ_FhYUNC9DmeSkzZlmozJtFB_vSmteiccSOA870nyhLFXApYChHq3XW79tJQg5BJKQf-ELQT0qoIO2qdsASBlVdriil3nvIWya1X_nF1JWXeq6esF-3UfZkpoZh9D5riLYc3diIcYoreZR8enFKc4-tJ0jszMMcx-KAFKHkd-Sh78fOS4Rh_yzOcN8U0MdByI-ITzJq4p8G9I4ZTy47jPfMR0QHrBnjkcM728rDfs8dPHH3dfqoevn-_vPjxUpoHVXFmrWlc3g-tQ9giEdSudA2uIeoF1I6Qiau0wONM2FlYNmK7ulTBKiRaFrW_Y7XluecnPPeVZ73w2NI4YKO6zFsVL4aUSBRVn1KSYcyKnp-R3mI4F0iflequLcn1SrqEU9CXz-jJ-P-zI_k38cVyAtxcAs8HRJQzG539c2zV9q1Th3pw5h1HjOhXm8Xs5SQFA3cl-VYj3Z4KKroOnpLPxFAxZn8rXaBv9fy76G6IFqs4</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Mihai, Cristina Manuela</creator><creator>Mărghitaş, Liviu Al</creator><creator>Dezmirean, Daniel S.</creator><creator>Chirilă, Flore</creator><creator>Moritz, Robin F.A.</creator><creator>Schlüns, Helge</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae</title><author>Mihai, Cristina Manuela ; Mărghitaş, Liviu Al ; Dezmirean, Daniel S. ; Chirilă, Flore ; Moritz, Robin F.A. ; Schlüns, Helge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c407t-dd65f34bf8a29a0ea352ff0dcee91a34126ee5dbbfc54d0740c83961c6615a1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>American foul brood</topic><topic>American Foulbrood</topic><topic>Animal productions</topic><topic>Animals</topic><topic>Anti-Infective Agents - chemistry</topic><topic>Anti-Infective Agents - pharmacology</topic><topic>antibacterial properties</topic><topic>Apiculture</topic><topic>Apis mellifera</topic><topic>Bees - drug effects</topic><topic>Bees - microbiology</topic><topic>Biological and medical sciences</topic><topic>Flavonoids</topic><topic>Flavonoids - chemistry</topic><topic>Fundamental and applied biological sciences. 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subjects American foul brood
American Foulbrood
Animal productions
Animals
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
antibacterial properties
Apiculture
Apis mellifera
Bees - drug effects
Bees - microbiology
Biological and medical sciences
Flavonoids
Flavonoids - chemistry
Fundamental and applied biological sciences. Psychology
honey bee colonies
honey bees
Insecta
Invertebrates
larvae
Microbial Sensitivity Tests
Paenibacillus
Paenibacillus larvae
pathogens
Polyphenols
Propolis
Propolis - chemistry
Propolis - pharmacology
resins
Terrestrial animal productions
title Interactions among flavonoids of propolis affect antibacterial activity against the honeybee pathogen Paenibacillus larvae
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