Effect of persistent activation of phosphoinositide 3-kinase on heart

Insulin/insulin-like growth factor-1 (IGF-1) signaling plays an important role in many biological processes. The class IA isoform of phosphoinositide 3-kinase (PI3K) is an important downstream effector of the insulin/IGF-1 signaling pathway. The aim of this study is to examine the effect of persiste...

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Veröffentlicht in:	Life sciences (1973) 2012-04, Vol.90 (15-16), p.619-628
Hauptverfasser:	Niizuma, Shinichiro, Inuzuka, Yasutaka, Okuda, Junji, Kato, Takao, Kawashima, Tsuneaki, Tamaki, Yodo, Iwanaga, Yoshitaka, Yoshida, Yuki, Kosugi, Rie, Watanabe-Maeda, Kayo, Machida, Yoji, Tsuji, Shingo, Aburatani, Hiroyuki, Izumi, Tohru, Kita, Toru, Kimura, Takeshi, Shioi, Tetsuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Aging Analysis of Variance Animals beta-galactosidase Blotting, Western cell cycle Cellular Senescence - physiology chromosomes cytokines Echocardiography Enzyme Activation - physiology Fluorescent Antibody Technique Gene expression Gene Expression Regulation - physiology genes heart Heart - physiology heat shock response Insulin insulin receptors insulin-like growth factor I Insulin-Like Growth Factor I - metabolism Male Mice Mice, Inbred C57BL Mice, Transgenic Microarray Analysis microarray technology mutants phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - metabolism Phosphoinositide 3-kinase Real-Time Polymerase Chain Reaction senescence signal transduction Signal Transduction - physiology Sirolimus transgenic animals
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