Replicative aging and differentiation potential of human adipose tissue-derived mesenchymal stromal cells expanded in pooled human or fetal bovine serum

Background aims Mesenchymal stromal cells (MSC) are promising candidates for innovative cell therapeutic applications. For clinical-scale manufacturing, different supplements have been evaluated as alternatives for the commonly used fetal bovine serum (FBS). We have reported previously that pooled h...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2012-05, Vol.14 (5), p.570-583
Hauptverfasser:	Bieback, Karen, Hecker, Andrea, Schlechter, Tanja, Hofmann, Ilse, Brousos, Nikos, Redmer, Torben, Besser, Daniel, Klüter, Harald, Müller, Albrecht M, Becker, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - cytology Adipose Tissue - metabolism adipose tissue-derived mesenchymal stromal cells Adult Advanced Basic Science Animals Cattle Cell Culture Techniques Cell Differentiation - drug effects Cell Proliferation - drug effects Cells, Cultured Culture Media - pharmacology Female fetal bovine serum Fibroblasts - cytology human serum Humans long-term culture Mesenchymal Stromal Cells - cytology Middle Aged Other potency replicative aging safety Serum
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